Results 21 to 30 of about 815,824 (234)

Stops making sense: translational trade-offs and stop codon reassignment [PDF]

, 2011
Background Efficient gene expression involves a trade-off between (i) premature termination of protein synthesis; and (ii) readthrough, where the ribosome fails to dissociate at the terminal stop. Sense codons that are similar in sequence to stop codons
Steven C Le Comber, Johnson, Louise J, Johnson, LJ, Le Comber Steven C, Nichols Richard A, Louise J Johnson, Polly, PD, Lichtenstein, CP, Polly p David, Cotton, James A., Le Comber, SC, p David Polly, Le Comber, Steven C., Conrad P Lichtenstein, Cotton, JA, Nichols, RA, Lichtenstein Conrad P, James A Cotton, Elgar, GS, Elgar, Greg S., Lichtenstein, Conrad P., Elgar Greg S, Nichols, Richard A., Greg S Elgar, Cotton James A, Johnson Louise J, Johnson, Louise J., Richard A Nichols, Polly, P. David   +28 more
core   +2 more sources

Advances in therapeutic use of a drug-stimulated translational readthrough of premature termination codons

Molecular Medicine, 2018
Premature termination codons (PTCs) in the coding regions of mRNA lead to the incorrect termination of translation and generation of non-functional, truncated proteins.
Maciej Dabrowski, Zuzanna Bukowy-Bieryllo, Ewa Zietkiewicz   +2 more
doaj   +1 more source

Translation Initiation Factors eIF3 and HCR1 Control Translation Termination and Stop Codon Read-Through in Yeast Cells [PDF]

, 2013
Translation is divided into initiation, elongation, termination and ribosome recycling. Earlier work implicated several eukaryotic initiation factors (eIFs) in ribosomal recycling in vitro.
Lucie Cuchalová, Lucie Cuchalová (153753), Wagner, Susan, Valasek, Leos S, Cuchalova, Lucie, Petra Beznosková (488568), Susan Wagner, Shoemaker, Christopher J, von der Haar, Tobias, Christopher J Shoemaker, Stanislava Gunišová (153731), Susan Wagner (488569), Beznoskova, Petra, Christopher J. Shoemaker (259606), Leoš Shivaya Valášek (153772), Gunisova, Stanislava, Stanislava Gunišová, Tobias von der Haar, Tobias von der Haar (80575), Petra Beznosková, Leoš Shivaya Valášek   +20 more
core   +2 more sources

Decoding accuracy in eRF1 mutants and its correlation with pleiotropic quantitative traits in yeast [PDF]

, 2010
Translation termination in eukaryotes typically requires the decoding of one of three stop codons UAA, UAG or UGA by the eukaryotic release factor eRF1.
Mugnier, Pierre M., von der Haar, Tobias, Gloria H Merritt (16282583), Mick F Tuite (16282592), Wesley R Naemi (16282586), Helen Webb (5178887), Pierre Mugnier (16282589), Webb, Helen M., Tobias von der Haar (80575), Merritt, Gloria H., Tuite, Mick F., Naemi, Wesley R.   +11 more
core   +1 more source

The Effect of Mutation at Thr 295 of Saccharomyces cerevisiae eRF1 on Suppression of Nonsense Codons and eRF1 Structure

Microbiology Indonesia, 2008
The termination of translation in Saccharomyces cerevisiae is controlled by two interacting polypeptide chain release factors, eRF1, and eRF3. Two regions in eRF1, at position 281-305 and 411-415, were proposed to be involved on the interaction to eRF3 ...
PRIMA ENDANG SUSILOWATI, PINGKAN ADITIAWATI, FIDA MADAYANTI, . AKHMALOKA   +3 more
doaj   +1 more source

Functional Restoration of BRCA1 Nonsense Mutations by Aminoglycoside-Induced Readthrough

Frontiers in Pharmacology, 2022
BRCA1 is a major tumor suppressor that functions in the accurate repair of DNA double-strand breaks via homologous recombination (HR). Nonsense mutations in BRCA1 lead to inactive truncated protein products and are associated with high risk of breast and
Renata B. V. Abreu, Thiago T. Gomes, Thales C. Nepomuceno, Thales C. Nepomuceno, Xueli Li, Mateus Fuchshuber-Moraes, Giuliana De Gregoriis, Guilherme Suarez-Kurtz, Alvaro N. A. Monteiro, Marcelo A. Carvalho, Marcelo A. Carvalho   +10 more
doaj   +1 more source

2A peptides provide distinct solutions to driving stop-carry on translational recoding [PDF]

, 2011
Funded by the U.K. Biotechnology and Biological Sciences Research Council (BB/E/01070911)Expression of viral proteins frequently includes non-canonical decoding events (‘recoding’) during translation. ‘2A’ oligopeptides drive one such event, termed ‘stop-
Yan, F, Doronina, V, Jeremy D. Brown, Fu Yan, Ryan, Martin D, Brown, Jeremy D, Escuin-Ordinas, Helena, Martin D. Ryan, Doronina, Victoria A, Ryan, Martin Denis, Sharma, Pamila, Sharma, P, Brown, Jeremy, Yan, Fu, Helena Escuin-Ordinas, Pamila Sharma, Victoria A. Doronina   +16 more
core   +1 more source

A Genetically Encoded Picolyl Azide for Improved Live Cell Copper Click Labeling

Frontiers in Chemistry, 2021
Bioorthogonal chemistry allows rapid and highly selective reactivity in biological environments. The copper-catalyzed azide–alkyne cycloaddition (CuAAC) is a classic bioorthogonal reaction routinely used to modify azides or alkynes that have been ...
Birthe Meineke, Birthe Meineke, Johannes Heimgärtner, Johannes Heimgärtner, Alexander J. Craig, Michael Landreh, Lindon W. K. Moodie, Lindon W. K. Moodie, Simon J. Elsässer, Simon J. Elsässer   +9 more
doaj   +1 more source

Nonsense mRNA suppression via nonstop decay

eLife, 2018
Nonsense-mediated mRNA decay is the process by which mRNAs bearing premature stop codons are recognized and cleared from the cell. While considerable information has accumulated regarding recognition of the premature stop codon, less is known about the ...
Joshua A Arribere, Andrew Z Fire
doaj   +1 more source

Improved ANAP incorporation and VCF analysis reveal details of P2X7 current facilitation and a limited conformational interplay between ATP binding and the intracellular ballast domain

eLife, 2023
The large intracellular C-terminus of the pro-inflammatory P2X7 ion channel receptor (P2X7R) is associated with diverse P2X7R-specific functions. Cryo-EM structures of the closed and ATP-bound open full-length P2X7R recently identified a membrane ...
Anna Durner, Ellis Durner, Annette Nicke
doaj   +1 more source