Results 61 to 70 of about 339,219 (259)
Molecular Oncology, EarlyView.This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi +6 more
wiley +1 more source
Stopping games: recent results [PDF]
We survey recent results on the existence of the value in zero-sum stopping games with discrete and continuous time, and on the existence of e-equilibria in non zero-sum games with discrete time.stopping games; stochastic games ...
VIEILLE, Nicolas, SOLAN, Eilon
core
Analysing busway station capacity under mixed stopping and non-stopping operation [PDF]
, 2015 Busway stations are the interface between passengers and services. The station is crucial to line operation as it is typically the only location where buses can pass each other.
Bunker, Jonathan M. +2 more
core
, 2008 A general result on the method of randomized stopping is proved. It is applied to optimal stopping of controlled diffusion processes with unbounded coefficients to reduce it to an optimal control problem without stopping.
Siska, David, Gyongy, Istvan
core +1 more source
Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer
Molecular Oncology, EarlyView.Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim +7 more
wiley +1 more source
On Infinite Horizon Optimal Stopping of General Random Walk [PDF]
The objective of this study is to provide an alternative characterization of the optimal value function of a certain Black- Scholes-type optimal stopping problem where the underlying stochastic process is a general random walk, i.e.
Jukka Lempa
core
Molecular Oncology, EarlyView.The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim +17 more
wiley +1 more source
On an Effective Solution of the Optimal Stopping Problem for Random Walks [PDF]
We find a solution of the optimal stopping problem for the case when a reward function is an integer function of a random walk on an infinite time interval. It is shown that an optimal stopping time is a first crossing time through a level defined as the
Albert Shiryaev, Alexander Novikov
core
Molecular Oncology, EarlyView.LVRF (lymphatic and vascular resistance factor) is a VEGFA splice variant upregulated in response to anti‐angiogenic therapy that fosters tumor adaptation through enhanced vascularization, lymphangiogenesis, and metastatic dissemination. Targeting LVRF with fully human neutralizing antibodies disrupts these processes and limits resistant tumor growth ...
Marion David +12 more
wiley +1 more source
The Optimal Stopping Problem of Dupuis and Wang: A Generalization [PDF]
In this paper, we study the optimal stopping problem of Dupuis and Wang analyzed in [7]. In this problem, the underlying follows a linear diffusion but the decision maker is not allowed to stop at any time she desires but rather on the jump times of an ...
Jukka Lempa
core