Results 51 to 60 of about 293,690 (314)

Stopping manoeuvre of high speed vessels fitted with screw and waterjet propulsion [PDF]

, 2009
Concern about the increase in high-speed vessel traffic necessitates steps to bring out safety guidelines in order to regulate and improve their manoeuvrability.
Krishnankutty, P., Varyani, K.
core  

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Ion stopping in dense plasma target for high energy density physics [PDF]

, 2010
The basic physics of nonrelativistic and electromagnetic ion stopping in hot and ionized plasma targets is thoroughly updated. Corresponding projectile-target interactions involve enhanced projectile ionization and coupling with target free electrons ...
Hasegawa, Jun, Sharkov, Boris Y., Deutsch, Claude, Chabot, Marin, Golubev, Alexey A., Ogawa, Masao, Bimbot, René, Jacoby, Joachim, Couillaud, Christophe, Mintsev, Victor, Della-Negra, Serge, Hoffmann, Dieter H. H., Wahl, H., Weyrich, Karin, Gardes, Daniel, Fleurier, Claude, Fertman, Alexander, Maynard, Gilles, Rivet, Marie-France, Tahir, Naeem Ahmad, Rosmej, Olga N., Fortov, Vladimir E., Oguri, Yoshiyuki   +22 more
core  

Proactive cues facilitate faster action reprogramming, but not stopping, in a response-selective stop signal task

Scientific Reports, 2023
The ability to stop simple ongoing actions has been extensively studied using the stop signal task, but less is known about inhibition in more complex scenarios.
Sauro E. Salomoni, Quentin F. Gronau, Andrew Heathcote, Dora Matzke, Mark R. Hinder   +4 more
doaj   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

The influence of dopaminergic polymorphisms on selective stopping [PDF]

, 2019
Although the genetic influence on global stopping has been extensively investigated, little is known about the genetic contribution to other more complex forms of inhibitory control such as selective stopping. The selectivity of inhibitory control can be
Sánchez Carmona, Alejandro, López Moreno, José Antonio, Echeverry Alzate, Víctor, Hinojosa Poveda, José Antonio, Buhler, Kora Mareen Katharina, Rincón Pérez, Irene, Albert Bitaube, Jacobo   +6 more
core   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Optimal Stopping via Reinforced Regression [PDF]

, 2020
In this note we propose a new approach towards solving numerically optimal stopping problems via reinforced regression-based Monte Carlo algorithms.
Schoenmakers, John G. M., Spokoiny, Vladimir, Zharkynbay, Bakhyt, Belomestny, Denis   +3 more
core   +1 more source

On the role of the striatum in response inhibition. [PDF]

PLoS ONE, 2010
BACKGROUND: Stopping a manual response requires suppression of the primary motor cortex (M1) and has been linked to activation of the striatum. Here, we test three hypotheses regarding the role of the striatum in stopping: striatum activation during ...
Bram B Zandbelt, Matthijs Vink
doaj   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source