Results 61 to 70 of about 48,940 (255)

Establishing an assay to evaluate d‐amino acid oxidase enzyme kinetics and inhibition using WST‐8 redox dye

FEBS Open Bio, EarlyView.
This study investigated a novel WST‐8‐based assay for evaluating d‐Amino acid oxidase (DAO) inhibitors. We confirmed its effectiveness using known inhibitors and found that uremic toxins possess relatively weak inhibitory activity compared to existing drugs.
Kahoko Miyake, Yuki Enoki, Yuka Nakazawa, Kazuaki Taguchi, Kazuaki Matsumoto   +4 more
wiley   +1 more source

Limited Gradient Descent: Learning With Noisy Labels

IEEE Access, 2019
Label noise may affect the generalization of classifiers, and the effective learning of main patterns from samples with noisy labels is an important challenge.
Yi Sun, Yan Tian, Yiping Xu, Jianxiang Li   +3 more
doaj   +1 more source

YIPFα1A expression is regulated by multilayered molecular mechanisms

FEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji, Yurika Nakanishi, Nobuhiro Nakamura   +2 more
wiley   +1 more source

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source

HTM-MDICE: a transformer-based model for predicting student engagement and ideological understanding in ethical education

Frontiers in Psychology
Tailoring individualized learning experiences depends on predicting student involvement and ideological awareness in ethical education, which is still difficult given educational data sets' complexity and class imbalance.
Chang Qin
doaj   +1 more source

Stopping set analysis of repeat multiple-accumulate codes

2009 IEEE International Symposium on Information Theory, 2009
In this work, we consider a stopping set analysis of repeat multiple-accumulate (RMA) code ensembles formed by the serial concatenation of a repetition code with multiple accumulators. The RMA codes are assumed to be iteratively decoded in a constituent code oriented fashion using maximum a posteriori erasure correction in the constituent codes.
Eirik Rosnes, Alexandre Graell i Amat
openaire   +2 more sources

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

A robust complex local mean decomposition method with self‐adaptive sifting stopping

Electronics Letters
Targets with rotating components generate micro‐motion (MM) modulation effect in addition to the main body. Extracting MM parameters is challenging due to interference from the target's main body, necessitating the separation of modulation signals.
CanYu Mo, QianQiang Lin, YuanDuo Niu, HaoRan Du   +3 more
doaj   +1 more source

Refinement of amino‐acid conformation vs. difference density maps in time‐resolved serial femtosecond crystallography data analysis

FEBS Open Bio, EarlyView.
The dFoCC pipeline starts with observed DED and resting‐state coordinates, which are then used to generate a library of triggered states. Correlation analysis of the calculated DED features of each candidate vs observed DED permits quantitative evaluation of candidate structural quality.
Meng Iao Fong, Yuhei Hosokawa, Lars Oliver Essen, Manuel Maestre‐Reyna   +3 more
wiley   +1 more source

Preventing Posterior Collapse with DVAE for Text Modeling

Entropy
This paper introduces a novel variational autoencoder model termed DVAE to prevent posterior collapse in text modeling. DVAE employs a dual-path architecture within its decoder: path A and path B.
Tianbao Song, Zongyi Huang, Xin Liu, Jingbo Sun   +3 more
doaj   +1 more source