Results 61 to 70 of about 48,906 (308)
A physical model revealing strong strain hardening in nano-grained metals induced by grain size gradient structure [PDF]
, 2015 A theoretical model has been developed, which reveals the underlying correlation between the strong extra strain hardening achieved in the nano-grained layers of the grain size gradient structure and the non-uniform deformation of the lateral surface in ...
Chen SH(陈少华) +4 more
core +1 more source
Strain hardening by sediment transport
Physical Review Research, 2022 The critical fluid-shear stress for the onset of sediment transport, θ_{c}, varies with the history of applied shear. This effect has been primarily attributed to compaction; the role of shear jamming is less explored.
Fernando D. Cúñez +4 more
doaj +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Materials Research Express, 2022 During hot working, alloys may experience three kinds of flow stress behaviors, including strain hardening, strain softening, or steady flow, because of the competition of work hardening and thermal softening. Modelling the flow stress behaviors plays an
Ruifan Meng, Liu Cao, Qindan Zhang
doaj +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source
Strain hardening in Fe-16Mn-10Al-0.86C-5Ni high specific strength steel
, 2016 We report a detailed study of the strain hardening behavior of a Fe-16Mn-10Al-0.86C-5Ni (weight percent) high specific strength (i.e. yield strength-to-mass density ratio) steel (HSSS) during uniaxial tensile deformation.
Xie QG +5 more
core +1 more source
Molecular Oncology, EarlyView.Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim +3 more
wiley +1 more source
FEBS Open Bio, EarlyView.CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point +7 more
wiley +1 more source
Plastic load evaluation for a fixed tube sheet heat exchanger subject to proportional loading
, 2012 The plastic load of pressurised components can be calculated based on both the twice elastic slope and tangent methods. Both methods are problematic since they rely on parameters that are localised and therefore have a strong dependency on the gradient ...
Behseta, Khosrow +5 more
core +1 more source