Results 61 to 70 of about 153,531 (299)

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Strain hardening by sediment transport

Physical Review Research, 2022
The critical fluid-shear stress for the onset of sediment transport, θ_{c}, varies with the history of applied shear. This effect has been primarily attributed to compaction; the role of shear jamming is less explored.
Fernando D. Cúñez, Erick M. Franklin, Morgane Houssais, Paulo Arratia, Douglas J. Jerolmack   +4 more
doaj   +1 more source

Material characterization at high strain by adapted tensile tests [PDF]

, 2011
The strength of materials at high strain levels has\ud been determined using the so-called Continuous-Bendingunder-\ud Tension (CBT) test. This is a modified tensile test\ud where the specimen is subjected to repetitive bending at the\ud same time.
Boogaard, A.H. van den, Emmens, W.C.
core   +3 more sources

Down‐regulation of Shh in the hair follicles of mice during chemotherapy‐induced hair loss is mediated by the JAK/STAT1 signaling pathway

FEBS Open Bio, EarlyView.
We found that during chemotherapy‐induced alopecia (CIA), Sonic hedgehog (Shh) expression significantly decreased in hair follicle Shh+ cells, whereas the Janus‐activated kinase/signal transducer and activator of transcription 1 (JAK/STAT1) signaling pathway was markedly activated.
Ruifang Fan, Jingling Huang, Xiang Lin, Tingjiao Lan, Yuli Tang, Ling Sun, Guixuan Zhou   +6 more
wiley   +1 more source

Constitutive modeling for the flow stress behaviors of alloys based on variable order fractional derivatives

Materials Research Express, 2022
During hot working, alloys may experience three kinds of flow stress behaviors, including strain hardening, strain softening, or steady flow, because of the competition of work hardening and thermal softening. Modelling the flow stress behaviors plays an
Ruifan Meng, Liu Cao, Qindan Zhang
doaj   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

Thermo-mechanical FE model with memory effect for 304L austenitic stainless steel presenting microstructure gradient [PDF]

, 2012
The main purpose of this study is to determine, via a three dimensions Finite Element analysis (FE), the stress and strain fields at the inner surface of a tubular specimen submitted to thermo-mechanical fatigue.
Bompard, Philippe, Clavel, Michel, Curtit, Francois, Pécheur, Anne Le, Rey, Colette, Stephan, Jean-Michel   +5 more
core   +6 more sources

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source

A novel indicator for kinematic hardening effect quantification in deep drawing simulation [PDF]

, 2019
Deep drawing simulation techniques reduce tool design costs and improve tool performance and reliability. In terms of strain hardening, mixed models capturing the kinematic effect are sometimes more accurate than isotropic models.
Brosius, Alexander, Küsters, Niklas, Lafarge, Rémi   +2 more
core  

Why is Understanding Glassy Polymer Mechanics So Difficult?

, 2011
In this Perspective, I describe recent work on systems in which the traditional distinctions between (i) unentangled vs. well-entangled systems and (ii) melts vs. glasses seem least useful, and argue for the broader use in glassy polymer mechanics of two
Angell, Arruda, Baljon, Boyce, Capaldi, Chen, Chen, Chen, Chen, de Focatiis, Doi, Dupaix, Ediger, Everaers, Fetters, Foffi, Govaert, Govaert, Graessley, Haward, Haward, Hoy, Hoy, Hoy, Hoy, Hoy, Koga, Kramer, Kremer, Lee, Lee, Loo, Mattson, McGraw, McLeish, O'Hern, Plimpton, Riggleman, Senden, Stillinger, Tkachenko, Ube, Uchidaa, van Melick, Varghese, Warren, Ylitalo   +46 more
core   +1 more source