Results 71 to 80 of about 1,250,898 (288)

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba, Mark Shacker, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal   +5 more
wiley   +1 more source

Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes

FEBS Open Bio, EarlyView.
Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard, Emma‐Jayne Proctor, Jiawa Wang, Nikolas P. Johnston, Andrew Hayes, Georgia McCorkell, Haibo Yu, Jai Tree, Mark R. Davies, Mark J. Walker, Ronald Sluyter, Stephan Brouwer, Martina L. Sanderson‐Smith   +12 more
wiley   +1 more source

Multi-stage strain-hardening behavior of dual-phase steels: A review

Journal of Materials Research and Technology
Regardless of the abundant studies that have been published on various characteristics of dual-phase (DP) steels, a comprehensive review paper on the strain-hardening behavior of such materials is still lacking.
Y. Najafi, Y. Mazaheri, Z. Delbari Ragheb, H. Daiy   +3 more
doaj   +1 more source

Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells

FEBS Open Bio, EarlyView.
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim, Marco Corazzari, Iman Osman, Jane Armstrong, Noel Carter   +4 more
wiley   +1 more source

SOME ASPECTS OF FRICTION AND ANISOTROPIC RATIOS ON THE WORK HARDENING BEHAVIOR IN THE UPSETTING TESTS [PDF]

Proceedings on Engineering Sciences
Metal upsetting is a primary mechanical working operation to reduce the cross-section of the billets, and there are few challenges that are to be solved.
Harikrishna Ch , Varun Chandra Samudrala , Murahari kolli , Srinivasaraju Perecherla , N Malleswararao Battina , Srinivasarao Gajula   +5 more
doaj   +1 more source

Nanoscale Strain-Hardening of Keratin Fibres

PLoS ONE, 2012
Mammalian appendages such as hair, quill and wool have a unique structure composed of a cuticle, a cortex and a medulla. The cortex, responsible for the mechanical properties of the fibers, is an assemblage of spindle-shaped keratinized cells bound together by a lipid/protein sandwich called the cell membrane complex. Each cell is itself an assembly of
Patrick Fortier, Sandy Suei, Laurent Kreplak   +2 more
openaire   +4 more sources

Analysis of strain hardening of ADI at isothermal hardening temperatures

Bulletin of the National Technical University «KhPI» Series: New solutions in modern technologies, 2020
The effect of isothermal hardening temperature on the mechanical properties of ADI materials is investigated. The heat treatment of the test samples consisted of the heating above the temperature of transformation of the ferrite component in austenite and isothermal hardening at temperatures from 280 to 380 °C.
Gogaev, Kazbek, Podrezov, Yuriy, Voloshchenko, Sergey, Askerov, Mukafat Geibat ogly, Minakov, Nikolay, Lugоvskoy, Yuri   +5 more
openaire   +3 more sources

Yeast Gcn2 retains activity following humanization of its auto‐phosphorylation region

FEBS Open Bio, EarlyView.
Using Saccharomyces cerevisiae as a model to study Gcn2 activation and regulation is limited by the lack of antibodies detecting phosphorylated Gcn2. To overcome this, we engineered Gcn2‐HsC, a yeast Gcn2 variant recognizable by commercial anti‐human phospho‐GCN2 antibodies.
Reuben A. Anderson, Anja H. Schiemann, Evelyn Sattlegger   +2 more
wiley   +1 more source

Importin 7 mediates the nuclear import of HIV‐1 integrase via a specific interacting interface

FEBS Open Bio, EarlyView.
HIV‐1 integrase enables viral DNA integration into the host genome. By binding to the core domain of the host protein Importin 7 via its C‐terminal domain, the integrase is transported across the nuclear membrane into the nucleus, where integration of the viral genome into host DNA takes place. This translocation is a critical step for subsequent viral
Juana Bana, Avigail Yariv, Tal Oppenheim, Hadar Amartely, Dana Reichmann, Oded Livnah   +5 more
wiley   +1 more source

Evaluating the effect of γ‐oryzanol on MASLD pathology using a medaka fish model

FEBS Open Bio, EarlyView.
This study explores a liver disease called MASLD, which is increasing worldwide and can lead to serious damage. Researchers used medaka fish instead of rodents to test a food compound, γ‐oryzanol. Fish fed this compound had less liver fat and healthier gut bacteria.
Yukako Ito, Haduki Asano, Ayano Ueki, Joe Sakamoto, Yasuhiro Kamei, Hayato Tokumoto, Ayaka Yazawa, Shigeki Kamitani   +7 more
wiley   +1 more source