Results 201 to 210 of about 44,419 (247)

Surfaceome Reprogramming of Stemsomes Promotes Lung Cancer Targeting via Potentiated Receptor–Ligand Interactions

Advanced Science, EarlyView.
This study presents a surfaceome‐reprogramming strategy for mutation‐independent lung cancer therapy by repurposing dexamethasone to prime mesenchymal stem cell‐derived nanovesicles. The engineered vesicles leverage multi‐valent interactions mediated by upregulated adhesion proteins, EPHA2, and NOTCH3.
Geunhye Kim, In Ah Kwon, Bo Seop Jeong, Hyo Seon Kim, Joo‐Hwan Park, Sung Jean Park, Sang‐Rae Lee, Youngki Lee, Dongwoo Khang   +8 more
wiley   +1 more source

Pharmacological Inhibition of FKBP51 Mitigates Early Life Adversity‐Induced Social Deficits in Male Mice

Advanced Science, EarlyView.
Early life adversity triggers persistent social subordination and brain‐wide molecular dysregulation. Pharmacological inhibition of the stress‐mediator FKBP51 during the adversity period prevents these long‐term deficits and restores normative social hierarchy.
Joeri Bordes, Xiuqi Ji, Serena Gasperoni, Choham Sudre‐Chinsky, Amirali Kalbasi, Daniela Harbich, Cornelia Flachskamm, Paula Fontanet, Sowmya Narayan, Manfred Uhr, Christian Namendorf, Camilla Bellone, Alon Chen, Felix Hausch, Juan Pablo Lopez, Mathias V. Schmidt   +15 more
wiley   +1 more source

CREAT: A CRISPR‐Based Genome Trimming Strategy for Systematic Identification of Dispensable Regions and Rapid Genome Reduction

Advanced Science, EarlyView.
Current genome‐reduction methods work in a trial‐and‐error fashion, constituting a long‐standing bottleneck in the research. We developed CREAT (CRISPR‐based genome trimming with a multi‐homology‐arm template), a CRISPR‐based genetic approach that enables systematically classifying essential versus non‐essential genomic regions and subsequently ...
Guanhua Yuan, Zhe Gao, Yingxuan Qi, Yang Zhang, Xuhui Tian, Pengpeng Zhao, Xu Feng, Qunxin She   +7 more
wiley   +1 more source

Designer Dynamic DNA Nanoaggregate in Living Cell for Mitochondrial Energy Restriction

Advanced Science, EarlyView.
This study presents the Tech‐tetrahedron, a designer dynamic DNA nanoaggregate engineered for precise mitochondrial energy restriction. Its trinity‐functionalized design integrates navigable unit, telomerase‐activated latch, and self‐assembly module.
Ruijia Deng, Jing Sheng, Ben Niu, Wenjuan Fu, Yingjie Yang, Zuowei Xie, Shuang Xie, Yunxuan He, Meilin Gong, Jue Wang, Yan Pi, Ming Chen, Kai Chang   +12 more
wiley   +1 more source

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Strand Displacement Strategies for Biosensor Applications

Trends in Biotechnology, 2019
DNA has many unique properties beyond encoding genetic information, one of which is its physicochemical stability based on Watson-Crick base pairing. Differences in sequence complementarity between multiple DNA strands can lead to the strand displacement reaction (SDR).
Ariel Fürst, Yifan Dai, Chung Chiun Liu   +2 more
exaly   +3 more sources

Biocomputing Based on DNA Strand Displacement Reactions

ChemPhysChem, 2021
AbstractThe high sequence specificity and precise base complementary pairing principle of DNA provides a rich orthogonal molecular library for molecular programming, making it one of the most promising materials for developing bio‐compatible intelligence. In recent years, DNA has been extensively studied and applied in the field of biological computing.
Qian Li, Chunhai Fan, Jiye Shi
exaly   +3 more sources

An emergent understanding of strand displacement in RNA biology

Journal of Structural Biology, 2019
DNA and RNA are generally regarded as central molecules in molecular biology. Recent advancements in the field of DNA/RNA nanotechnology successfully used DNA/RNA as programmable molecules to construct molecular machines and nanostructures with predefined shapes and functions.
Fan Hong, Petr Sulc
exaly   +3 more sources

The neuronal perceptron with DNA strand displacement

2018 Tenth International Conference on Advanced Computational Intelligence (ICACI), 2018
In the field of biologic computing and neural networks, DNA strand displacement technology performs well in computing, programming and information processing. In this paper, based on two-domain DNA strand displacement, the neural DNA perceptron is proposed to implement Boolean operations. Some operation instances are simulated by Visual DSD (DNA strand
Lanlan Shi, Changjun Zhou, Qiang Zhang 0008   +2 more
openaire   +1 more source

Heterochiral DNA Strand-Displacement Circuits

Journal of the American Chemical Society, 2017
The absence of a straightforward strategy to interface native d-DNA with its enantiomer l-DNA-oligonucleotides of opposite chirality are incapable of forming contiguous Watson-Crick base pairs with each other-has enforced a "homochiral" paradigm over the field of dynamic DNA nanotechnology.
Adam M. Kabza, Brian E. Young, Jonathan T. Sczepanski   +2 more
openaire   +2 more sources

DNA Strand-Displacement Timer Circuits

ACS Synthetic Biology, 2016
Chemical circuits can coordinate elaborate sequences of events in cells and tissues, from the self-assembly of biological complexes to the sequence of embryonic development. However, autonomously directing the timing of events in synthetic systems using chemical signals remains challenging.
Joshua, Fern, Dominic, Scalise, Angelo, Cangialosi, Dylan, Howie, Leo, Potters, Rebecca, Schulman   +5 more
openaire   +2 more sources