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Strand Displacement Strategies for Biosensor Applications
Trends in Biotechnology, 2019DNA has many unique properties beyond encoding genetic information, one of which is its physicochemical stability based on Watson-Crick base pairing. Differences in sequence complementarity between multiple DNA strands can lead to the strand displacement reaction (SDR).
Yifan Dai +2 more
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The neuronal perceptron with DNA strand displacement
2018 Tenth International Conference on Advanced Computational Intelligence (ICACI), 2018In the field of biologic computing and neural networks, DNA strand displacement technology performs well in computing, programming and information processing. In this paper, based on two-domain DNA strand displacement, the neural DNA perceptron is proposed to implement Boolean operations. Some operation instances are simulated by Visual DSD (DNA strand
Lanlan Shi +2 more
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DNA Strand-Displacement Timer Circuits
ACS Synthetic Biology, 2016Chemical circuits can coordinate elaborate sequences of events in cells and tissues, from the self-assembly of biological complexes to the sequence of embryonic development. However, autonomously directing the timing of events in synthetic systems using chemical signals remains challenging.
Joshua, Fern +5 more
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Biocomputing Based on DNA Strand Displacement Reactions
ChemPhysChem, 2021AbstractThe high sequence specificity and precise base complementary pairing principle of DNA provides a rich orthogonal molecular library for molecular programming, making it one of the most promising materials for developing bio‐compatible intelligence. In recent years, DNA has been extensively studied and applied in the field of biological computing.
Qian Li, Jiye Shi, Chunhai Fan
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Heterochiral DNA Strand-Displacement Circuits
Journal of the American Chemical Society, 2017The absence of a straightforward strategy to interface native d-DNA with its enantiomer l-DNA-oligonucleotides of opposite chirality are incapable of forming contiguous Watson-Crick base pairs with each other-has enforced a "homochiral" paradigm over the field of dynamic DNA nanotechnology.
Adam M. Kabza +2 more
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Analog Computation by DNA Strand Displacement Circuits
ACS Synthetic Biology, 2016DNA circuits have been widely used to develop biological computing devices because of their high programmability and versatility. Here, we propose an architecture for the systematic construction of DNA circuits for analog computation based on DNA strand displacement.
Tianqi, Song +4 more
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Autonomous Resolution Based on DNA Strand Displacement
2011We present a computing model based on the technique of DNA strand displacement which performs a chain of logical resolutions with logical formulae in conjunctive normal form. The model is enzymefree and autonomous. Each clause of a formula is encoded in a separate DNA molecule: propositions are encoded assigning a strand to each proposition p, and its ...
Alfonso Rodríguez-Patón +2 more
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Circular DNA Logic Gates with Strand Displacement
Langmuir, 2009Circular DNA logic gates were constructed on the basis of DNA three-way branch migration. In this logic system, circular DNA was used as a basic work unit and linear single-strand DNA was used as input and output signals. Making use of the circular structure, most of the DNA-specific recognition regions were designed in a single DNA ring.
Cheng, Zhang, Jing, Yang, Jin, Xu
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Connecting localized DNA strand displacement reactions
Nanoscale, 2015Design and characterization of a DNA-based localized amplification circuit which, upon tethering on a DNA origami platform, greatly accelerates the catalytic response.
Ismael Mullor, Ruiz +5 more
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Robustness of Localized DNA Strand Displacement Cascades
ACS Nano, 2014Colocalization can strongly alter the kinetics and efficiency of chemical processes. For instance, in DNA-templated synthesis unfavorable reactions are sped up by placing reactants into close proximity onto a DNA scaffold. In biochemistry, clustering of enzymes has been demonstrated to enhance the reaction flux through some enzymatic cascades.
Mario, Teichmann +2 more
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