Mechanisms of NAFLD development and therapeutic strategies
Nature Medicine, 2018 S. Friedman +3 more
semanticscholar +1 more source
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
Determinants of DMC technologies adoption among smallholders in the Lake Alaotra area, Madagascar : Document de travail BV lac n° 45 [PDF]
, 2008 Les techniques de systèmes de semis direct sur couverture végétale (SCV) sont diffusées depuis une dizaine d'années à Madagascar. Ils répondent à des objectifs de préservation de l'environnement, de création de revenus et de réduction de la pauvreté, en ...
Andriamalala, Herizo +5 more
core
Mechanisms of IgE‐mediated food allergy and the role of allergen‐specific B cells
FEBS Letters, EarlyView.Food allergy arises when allergen‐specific B cells preferentially produce immunoglobulin E (IgE) antibodies against harmless foods. This article explains the mechanisms driving IgE‐mediated reactions, highlights the central role of these B cells, and discusses how natural tolerance (NT) and oral immunotherapy (OIT) can reshape allergic immune responses.
Juan‐Felipe López +2 more
wiley +1 more source
A New FRamework to Study Decision in Organisation [PDF]
The purpose of this communication is to display an original decision model - the Decisional Fit Model. Based on other models of fit, this model focuses on decision making when using a decision support system.
Cécile Godé-Sanchez +1 more
core
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
“PROPUESTA DE ACTIVIDADES PARA EL USO DE ESTRATEGIAS COGNITIVAS Y METACOGNITIVAS EN LA COMPRENSIÓN ORAL DEL FRANCÉS NIVEL B1.” [PDF]
, 2013 L’objectif de ce travail est d’aider les étudiants de français de Niveau B1 (du CECR) de la Faculté de Langues à améliorer leur compréhension orale (CO) en utilisant des stratégies cognitives et métacognitives.
Chávez Bello, Yuridiana +1 more
core
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
PORGY: a Visual Analytics Platform for System Modelling and Analysis Based on Graph Rewriting [PDF]
, 2017 PORGY is a visual environment for rule-based modelling based on port graphs and port graph rewrite rules whose application is steered by rewriting strategies.
Andrei, Oana +5 more
core +4 more sources
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source