This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley +1 more source
Determinants of DMC technologies adoption among smallholders in the Lake Alaotra area, Madagascar : Document de travail BV lac n° 45 [PDF]
Les techniques de systèmes de semis direct sur couverture végétale (SCV) sont diffusées depuis une dizaine d'années à Madagascar. Ils répondent à des objectifs de préservation de l'environnement, de création de revenus et de réduction de la pauvreté, en ...
Andriamalala, Herizo +5 more
core
Mechanisms of NAFLD development and therapeutic strategies
S. Friedman +3 more
semanticscholar +1 more source
Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer
Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani +4 more
wiley +1 more source
El francés de las humanidades y su traducción al español: calcos, préstamos, xenismos y adaptaciones
Cet article concerne la réception en espagnol de la terminologie des Sciences humaines produite en français. Il s’agit de montrer la manière dont on a adopté la terminologie française en espagnol, et de décrire quelles sont les stratégies utilisées dans ...
Emilio Ortega Arjonilla
doaj
New options for pest management in horticultural crop-based agroecosystems of Sudano-Sahelian Africa in the climate change context [PDF]
In the climate change context, ICRISAT is promoting water-saving cropping systems mixing food and horticultural crops for the Sudano-Sahelian zone of Western Africa. ICRISAT's partners in Niger (CIRAD, the University of Niamey and INRAN) are seeking ways
Fatondji, Dougbedji +9 more
core
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
Remittances as a Social Status Signaling Device [PDF]
L'article étudie les transferts des migrants en tant que moyen pour signaler leur situation économique aux yeux des résidents. En information imparfaite, les migrants pauvres peuvent transférer plus que normal, pour se faire passer pour des migrants ...
Claire Naiditch, Radu Vranceanu
core
The role of histone modifications in transcription regulation upon DNA damage
This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley +1 more source
Function‐driven design of a surrogate interleukin‐2 receptor ligand
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang +9 more
wiley +1 more source

