Results 221 to 230 of about 520,678 (289)
Advanced Science, EarlyView.GNL3 is a novel AR coregulator with dual coactivator and corepressor functions in prostate cancer (PCa). Our study uncovers a previously unrecognized mechanism by which the AR transcriptional complex integrates oncogenic signaling and immune suppression.
Cuiting Zhang +12 more
wiley +1 more source
Innovations in Nursing Education, Practice and Research: Emphasising Health Literacy. [PDF]
Nurs RepMartínez-Sabater A +2 more
europepmc +1 more source
Advanced Science, EarlyView.The oral bacterium Streptococcus salivarius promotes colorectal cancer metastasis by inducing neutrophil extracellular trap (NET) formation. Mechanistically, IRGM1–IQGAP1 interaction activates Wnt5a–PI3K/AKT signaling in neutrophils, driving NET‐mediated tumor progression.
Fengyi Liu +13 more
wiley +1 more source
Proactive postgraduate education in disaster medicine and preparedness for enhanced disaster management. [PDF]
BMC Med EducZimmerman J +6 more
europepmc +1 more source
A Soft Robotic Model for Simulating Heart Valve Disease and Cardiac Interventions
Advanced Science, EarlyView.This paper introduces a fully synthetic fabrication methodology for a soft robotic, in‐vitro model of the left‐heart, complete with a functioning mitral valve apparatus. With a view towards patient‐specific modeling, we demonstrate physiological flow and pressure waveforms, tunable mitral valve function with clinical imaging compatibility, and its use ...
James Davies +14 more
wiley +1 more source
A scoping review of EFL learners' interlanguage pragmatic development. [PDF]
PLoS OneLi H, Kasim ZM, Ang LH.
europepmc +1 more source
Structure‐Guided Engineering of a Cas12i Nuclease Unlocks Near‐PAMless Genome Editing
Advanced Science, EarlyView.CRISPR‐Cas nucleases are limited by PAM requirements, restricting genome accessibility. Structure‐guided engineering of the compact Cas12i nuclease SF01 produced three variants with near‐PAMless, enabling efficient editing at diverse 5'‐NNTN‐3' sites. These nucleases expand the editable portion of the human genome more than fourfold, enabling efficient
Qitong Chen +15 more
wiley +1 more source
β‐Adrenergic Signaling Promotes Anti‐Tumor Immunity in TP53‐mutant Oral Squamous Cell Carcinoma
Advanced Science, EarlyView.β‐adrenergic stimulation enhances anti‐tumor immunity in TP53‐deficient oral squamous cell carcinoma by inducing tumor‐derived secretion of CXCL10, which attracts and activates cytotoxic CD8+ T cells. The findings demonstrate that β‐adrenergic signaling alters tumor–immune interactions via CXCL10‐mediated paracrine activation, revealing a neuro‐immune ...
Frederico O. Gleber‐Netto +20 more
wiley +1 more source