Results 101 to 110 of about 86,084 (307)

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Handbook of Strategic Environmental Assessment [PDF]

Journal of Integrative Environmental Sciences, 2012
Handbook of Strategic Environmental Assessment, edited by Barry Sadler, Ralf Aschemann, Jiri Dusik, Thomas B. Fischer, Maria R.
openaire   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Addressing cumulative effects in Strategic Environmental Assessment of spatial planning

Aestimum, 2012
Strategic environmental Assessment (SEA) is a decision support instrument for predicting and evaluating the likely environmental effects of implementing a policy, plan or programme.
Chiara Bragagnolo, Davide Geneletti
doaj   +1 more source

DNA methylation and expression of MAPRE3 affect overall survival of early‐stage non‐small cell lung cancer patients

Molecular Oncology, EarlyView.
Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen, Jiancheng Cheng, Ruili Hou, Xiaoyuan Zheng, Li Su, Maria Moksnes Bjaanæs, Anna Karlsson, Maria Planck, Johan Staaf, Åslaug Helland, Manel Esteller, David C. Christiani, Feng Chen, Xiaofei Cao, Ruyang Zhang   +14 more
wiley   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Strategic Environmental Assessment and the Democratisation of Spatial Planning

, 2011
This paper investigates the potential of Strategic Environmental Assessment (SEA) to contribute to the high-level policy objective of fostering democratisation in spatial planning. Democratic SEA is conceptualised by discussing environmental citizenship,
GAZZOLA P., BONIFAZI A, REGA, CARLO, PAOLA GAZZOLA, CARLO REGA, ALESSANDRO BONIFAZI   +5 more
core   +2 more sources

Integrating climate change adaptation into municipal masterplans through Strategic Environmental Assessment (SEA)

TeMA: Journal of Land Use, Mobility and Environment
Adaptation to climate change and the need to deal with its impacts pose in evidence how important it is to identify and implement new planning practices that integrate these profiles into land-use policy-making.
Federica Isola, Sabrina Lai, Federica Leone, Corrado Zoppi   +3 more
doaj   +1 more source

Regional planning guideline review : using MOLAND as part of the strategic environmental assessment process

, 2009
The urban fabric of the Greater Dublin Area (GDA) has expanded rapidly over the past 20 years. In an effort to coordinate development across the region the “Strategic Planning Guidelines for the Greater Dublin Area” were introduced in 1999.
Brennan, Michael, Carty, John, Shahumyan, Harutyun, Walsh, Cormac, Williams, Brendan, Convery, Sheila   +5 more
core