Results 121 to 130 of about 818,638 (305)

Multi‐omics and low‐input proteomics profiling reveals dynamic regulation driving pluripotency initiation in early mouse embryos

FEBS Open Bio, EarlyView.
Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li, Xi Xiao, Lingbin Qi, Chanyi Li, Sirui Song, Jiaying Qin, Zhigang Xue, Jinfeng Xue, Huaifang Li   +8 more
wiley   +1 more source

A Methodology for Assessing National Sustainable Development Strategies [PDF]

At the Rio Earth Summit of 1992, governments undertook to develop and adopt national sustainable development strategies as a key component of implementing the goals of Agenda 21. Only partial progress was reported at the 2002 World Summit in Johannesburg,
Cherp, Aleg, George, Clive, Kirkpatrick, Colin   +2 more
core   +1 more source

Erythropoietin modulates hepatic inflammation, glucose homeostasis, and soluble epoxide hydrolase and epoxides in high‐fat diet‐induced obese mice

FEBS Open Bio, EarlyView.
Erythropoietin administration suppresses hepatic soluble epoxide hydrolase (sEH) expression, leading to increased CYP‐derived epoxides. This is associated with a shift in hepatic macrophage polarization characterized by reduced M1 markers and increased M2 markers, along with reduced hepatic inflammation, suppressed hepatic lipogenesis, and attenuated ...
Takeshi Goda, Satoru Sugimoto, Chiharu Cho, Madoka Konishi, Nozomi Inoue, Satoshi Miyagaki, Yasuhiro Kawabe, Takuro Okamura, Masahide Hamaguchi, Hisakazu Nakajima, Michiaki Fukui, Masakazu Shinohara, Tomoko Iehara   +12 more
wiley   +1 more source

Методологічні підходи до оцінки впливів надзвичайних ситуацій на навколишнє середовище [PDF]

, 2013
Розглянуто основні методологічні підходи процедури екологічної оцінки, які можуть бути застосовані для забезпечення екологічної безпеки в галузі запобігання та реагування на надзвичайні ситуації.
Варивода, Є. О.
core  

Exon 7 splicing of ERα predicts poor prognosis and increases phenotypic heterogeneity in luminal a subtype breast cancer

FEBS Open Bio, EarlyView.
ERα splice variant ERα∆7 lacks the C‐terminus, and its expression may change phenotypes of breast cancers. Our results showed that ERα∆7 is found in the luminal A subtype, and elevated ERα∆7 levels are linked to improved cell survival with lower proliferation and migration.
Long Wai Tsui, Taobo Hu, Thomson Christian Husein, Wai Hei Shek, Bingrong Chen, Depeng Wang, Shu Wang, Weichuan Yu, Xiaodan Fan, Mengping Long, Toyotaka Ishibashi   +10 more
wiley   +1 more source

Strategically Sustainable Environmental Assessment

, 2009
Large-scale planning initiatives can present major long-term environmental and social consequences. Strategic Environmental Assessment (SEA) is one type of approach to integrating environmental considerations into many large-scale plans and programs, and was established in the European Union by Council Directive 2001/42/EC.
Cécile, Hervé-Bazin, Nils, Klinkenberg, Matt, Milam   +2 more
openaire   +1 more source

Sustainable economic growth within environmental limits hypothetical case study: 'limitville' [PDF]

, 2010
A new approach to delivering ‘sustainable economic growth within environmental limits’ has been developed for the East Midlands. The approach is described in detail in a guidance document prepared by Land Use Consultants and GHK Consulting for emda and ...
GHK Consulting, Land Use Consultants
core  

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

Determining Sustainable Development Density using the Urban Carrying Capacity Assessment System [PDF]

, 2004
Diverse urban problems in the capital region of Korea occur due to over-development and over-concentration which exceed the region’s carrying capacity.
Jeong, Yeunwoo, Lee, Dongkun, Lee, Wangkey, Oh, Kyushik   +3 more
core  

Screening and epitope characterization of Nidogen‐2‐specific nanobodies

FEBS Open Bio, EarlyView.
Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen, Qianqian Cui, Zhongyun Lan, Yingjun Wang, Shuaiying Zhao, Wenxuan Feng, Yunfeng Liu, Qiting Huang, Dongna Zhang, Jianfeng Xu   +9 more
wiley   +1 more source