Results 111 to 120 of about 86,084 (307)

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

open access: yesMolecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka   +9 more
wiley   +1 more source

METHODOLOGY OF THE ENTERPRISE ADAPTATION STRATEGY DETERMINING

open access: yesEconomics & Education, 2019
This research paper reveals the step-by-step method of retail enterprises strategy adaptation determining. Alternatives of retail enterprise strategic goals achieving are substantiated in terms of adaptation to environmental factors effect for of retail
Victoria Grosul, Timur Askerov
doaj  

GIS-based Strategic Environmental Assessment

open access: yes
The intrinsic spatial nature of environmental assessment and, indeed, most planning decisions can significantly benefit from GIS-based analyses and outcomes.
González Del Campo, Ainhoa   +1 more
core  

Analysis for biotechnology innovations using Strategic Environmental Assessment (SEA): [PDF]

open access: yes
" Meeting the food needs of the world's growing population while reducing poverty and protecting the environment is a major global challenge. Genetically modified crops appear to provide a promising option to deal with this challenge.
Gaskell, Joanne   +6 more
core  

Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma

open access: yesMolecular Oncology, EarlyView.
Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski   +10 more
wiley   +1 more source

Strategic environmental assessment in urban development Case study: (Zahedan city) [PDF]

open access: yesعلوم محیطی, 2018
Introduction: Environmental problems are one of the most important issues in major cities, metropolises and it is the result of confliction with the natural environment because urban development is necessarily associated with the domination of buildings,
Zohreh Fanni   +2 more
doaj  

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

open access: yesMolecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola   +11 more
wiley   +1 more source

Road Ecology in Environmental Impact Assessment

open access: yes, 2014
Transport infrastructure has a wide array of effects on terrestrial and aquatic ecosystems, and road and railway networks are increasingly being associated with a loss of biodiversity worldwide.
Mörtberg, Ulla,   +2 more
core   +1 more source

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