Results 111 to 120 of about 812,510 (332)

METHODOLOGY OF THE ENTERPRISE ADAPTATION STRATEGY DETERMINING

open access: yesEconomics & Education, 2019
This research paper reveals the step-by-step method of retail enterprises strategy adaptation determining. Alternatives of retail enterprise strategic goals achieving are substantiated in terms of adaptation to environmental factors effect for of retail
Victoria Grosul, Timur Askerov
doaj  

Integrating climate change adaptation into municipal masterplans through Strategic Environmental Assessment (SEA)

open access: yesTeMA: Journal of Land Use, Mobility and Environment
Adaptation to climate change and the need to deal with its impacts pose in evidence how important it is to identify and implement new planning practices that integrate these profiles into land-use policy-making.
Federica Isola   +3 more
doaj   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

open access: yesMolecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla   +10 more
wiley   +1 more source

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

open access: yesMolecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li   +10 more
wiley   +1 more source

Effectiveness of strategic environmental assessment - the significance of learning [PDF]

open access: bronze, 2009
Urmila Jha‐Thakur   +4 more
openalex   +1 more source

How do environmental policies fit within larger strategic planning processes [PDF]

open access: yes, 2015
This chapter explores how environmental policies fit within larger strategic processes relevant to sport management and development. It identifies key policy areas such as environmental impact assessment, sustainable land use planning, environmental ...
Crowe, Lynn
core  

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

open access: yesMolecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala   +15 more
wiley   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

open access: yesMolecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung   +17 more
wiley   +1 more source

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