Results 111 to 120 of about 11,053,990 (295)

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

STRATEGIC ENVIRONMENTAL ASSESSMENT OF THE ADJUSTMENT PROCESS OF THE CITY MASTERPLAN TO THE SARDINIAN REGIONAL LANDSCAPE PLAN: THE CASE OF CITY MASTERPLAN OF ALGHERO, SARDINIA (ITALY) [PDF]

Strategic Environmental Assessment (SEA) in the context of the enactment of the Directive 2001/42/CE is at the core of the adjustment process of provincial and city Masterplan to the Sardinian Regional Landscape Plan (RLP).
Cheti Pira, Federica Isola
core  

Strategic environmental assessment: Effective planning instrument or lost concept

, 2002
After its 'invention' as a fairly clearly defined instrument for assessing the environmental impacts of policies, plans and programmes in the 1980s, at the end of the 1990s SEA appeared more an undefined concept than a clear and effective planning ...
Fischer, Thomas B., Seaton, Kim
core   +1 more source

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Strategic environmental assessment in Swedish municipal planning. Trends and challenges

, 2018
More than a decade after the implementation of the EU Directive on Strategic Environmental Assessment (SEA) into Swedish legislation, a comprehensive study has been conducted to analyze the development of SEA practice in municipal planning.
Wallström, J.,, Lundberg, K.,, Hornberg, C.,, Balfors, Berit,, Söderqvist, T.,, Högström, Johan,   +5 more
core   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

Efficiency of Strategic Environmental Assessment Methods in Municipality Land Use Plans

Prostor
The integration of environmental aspects in land use plans (LUPs) through SEA varies across Europe and their efficiency is still not well known, motivating the research of SEA implementation for LUPs.
Vesna Kolar Planinšič, Alma Zavodnik Lamovšek   +1 more
doaj   +1 more source

Designing a management framework for Strategic Environmental Assessment of urban plans in China

, 2009
Based on the revision of theMethods for Urban Plan Formulation and the Technical Guidelines of Environmental Impact Assessment for UrbanMaster Plan (in draft), this paper proposes a management framework for Strategic Environmental Assessment (SEA) of ...
Ou-Yang, L, Huang, He, Brown, AL, Bao, Cun-Kuan, Gao, Ying-wei, Jiang, Dahe, Brown, Lex, Zhou, Ying-lie, Gao, YW, Huang, H, Zhou, YL, Ou-Yang, Li, Jiang, D, Bao, CK   +13 more
core   +1 more source