Results 61 to 70 of about 7,964 (256)

SEA as Instrument in Responsible Planning of Tourist Destinations. Case Study of Djerdap National Park, Serbia [PDF]

open access: yesJournal of Environmental and Tourism Analyses, 2014
Recent practice in Serbia has recognized the Strategic Environmental Assessment (SEA) as an instrument of control in spatial, urban and environmental planning.
Marina NENKOVIĆ-RIZNIĆ   +2 more
doaj  

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

open access: yesFEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee   +7 more
wiley   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

open access: yesMolecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat   +8 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

open access: yesMolecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

open access: yesMolecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano   +6 more
wiley   +1 more source

THE ROLE OF SEA IN INTEGRATING THE ENVIRONMENTAL CONSIDERATIONS INTO THE PLANNING OF HYDROENERGETIC PLANTS [PDF]

open access: yesAerul şi Apa: Componente ale Mediului, 2013
The present paper offers an analysis of the concept of SEA and its role in the development of hydroenergetic plant planning. The article provides information related to the institutional aspects of the strategic environmental assessment processes, at the
Claudia-Thora Ionescu   +2 more
doaj  

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

open access: yesMolecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson   +9 more
wiley   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

open access: yesMolecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau   +36 more
wiley   +1 more source

Development of the Strategic Framework for Sustainable Development of the Special Economic Zones in ASEAN Economic Community: A Case Study of Savannakhet - Mukdahan

open access: yesApplied Environmental Research, 2017
The study proposes a strategic sustainable development (SD) framework for the special economic zones in the ASEAN Economic Community (AEC) by investigating 11 key factors to the success of SD, using the concepts of Strategic Environment Assessment (SEA)
Kantachon Siwapimon, Thavivongse Sriburi
doaj   +3 more sources

Integrating climate change adaptation into municipal masterplans through Strategic Environmental Assessment (SEA)

open access: yesTeMA: Journal of Land Use, Mobility and Environment
Adaptation to climate change and the need to deal with its impacts pose in evidence how important it is to identify and implement new planning practices that integrate these profiles into land-use policy-making.
Federica Isola   +3 more
doaj   +1 more source

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