Results 231 to 240 of about 928,628 (290)

Twelve Practical Tips for Integrating AI Into Medical Education: Tutorial to Support Educators Across Teaching, Research, Administration, and Ethical Domains.

JMIR Med Educ
Jalali A, Harbi Houssein K, Fotsing S.
europepmc   +1 more source

Digitalized human resources for health information systems in low- and middle-income countries: a scoping review. [PDF]

Hum Resour Health
Nagai M, Mufwaya-Nsene R, Thandar MM, Matsuoka S, Okawa S, Fujita N.   +5 more
europepmc   +1 more source

TBK1 Induces the Formation of Optineurin Filaments That Condensate with Polyubiquitin and LC3 for Cargo Sequestration

Advanced Science, EarlyView.
Phosphorylation of Optineurin by TBK1 induces the formation of filaments that condensate upon binding to linear polyubiquitin. Membrane‐anchored LC3 partitions into these condensates, suggesting that phase separation of filamentous Optineurin with ubiquitylated cargo promotes the sequestration of cargo and its subsequent alignment with LC3‐positive ...
Maria G. Herrera, Lena Kühn, Lisa Jungbluth, Verian Bader, Laura J. Krause, David Kartte, Elias Adriaenssens, Sascha Martens, Jörg Tatzelt, Carsten Sachse, Konstanze F. Winklhofer   +10 more
wiley   +1 more source

Operational challenges and adaptive leadership in emergency departments in the United States of America: a mixed-methods analysis. [PDF]

BMC Emerg Med
Animashaun E, Peprah EB, Olorunfemi O, Oyekunle O, Nortey-Adom E, Karbo S.   +5 more
europepmc   +1 more source

p16Ink4a‐Positive Hepatocytes Drive Liver Fibrosis Through Activation of LIFR Family Pathway

Advanced Science, EarlyView.
This study found that, following the long‐term CCl4 treatment, p16high hepatocytes appeared in zone 3, spatially co‐localizing with fibrotic areas. A specific cluster of p16high hepatocytes upregulated CTF1/LIF expression which induced HSC activation and further liver fibrosis, as revealed by single cell transcriptomic analysis.
Koji Nishikawa, Teh‐Wei Wang, Satoshi Kawakami, Shota Tanimoto, Kiyoshi Yamaguchi, Taketomo Kido, Masamichi Kimura, Tsunekazu Hishima, Yuki T. Okamura, Satotaka Omori, Takumi Iritani, Toshikaze Chiba, Takehiro Jimbo, Michio Katano, Kansuporn Kamataki, Ryoichi Yokoyama, Eigo Shimizu, Kiminori Kimura, Satoshi Yamzaki, Seiya Imoto, Yoichi Furukawa, Atsushi Miyajima, Yoshikazu Johmura, Makoto Nakanishi   +23 more
wiley   +1 more source

Fragmented Governance, Shared Landscapes: Policy and Functional (In)Coherence Insights from the Great Limpopo Transfrontier Conservation Area. [PDF]

Environ Manage
Mpofu E, Penker M, Musakwa W, Radinger-Peer V, Gugerell K.   +4 more
europepmc   +1 more source

A Hydrodynamic Bioreactor for High‐Yield Production of Extracellular Vesicles from Stem Cell Spheroids with Defined Cargo Profiling

Advanced Science, EarlyView.
This study harnesses hydrodynamic flows to generate, confine and stimulate stem cell spheroids, enabling the large‐scale production of extracellular vesicles (EVs). This innovative method not only streamlines spheroid formation and subsequent EV release in a single, integrated process, but also ensures the generation of EVs with enhanced biological ...
Solène Lenoir, Elliot Thouvenot, Giacomo Gropplero, Léonie Dec, Damarys Loew, Clotilde Théry, Jose E Perez, Claire Wilhelm   +7 more
wiley   +1 more source

Overcoming legacy system hurdles: a case study on enabling master facility registry interoperability within Ethiopia's national eHealth architecture. [PDF]

Oxf Open Digit Health
Bushira AH, Amanuel B, Legesse D, Wubshet D, Asfaw K, Tewodros K, Gemechis M.   +6 more
europepmc   +1 more source

Editorial: Advancing knowledge-based economies and societies through AI and optimization: innovations, challenges, and implications. [PDF]

Front Artif Intell
Tirkolaee EB, Ranjbarzadeh R, Weber GW.
europepmc   +1 more source

Identifying Key Indicators and Components of Earthquake Preparedness Exercises in the Prehospital Setting: An Exploratory Content Analysis From Paramedic Nurses' Perspectives. [PDF]

Nurs Res Pract
Aminafshar A, Khosravizad A, Sahebi A, Nekoeimoghadam M, Amiresmaili M, Tavan A, Farahmandnia H.   +6 more
europepmc   +1 more source