Results 151 to 160 of about 1,493,759 (300)

Opportunities to advance implementation science and nutrition research: a commentary on the Strategic Plan for NIH Nutrition Research. [PDF]

Transl Behav Med, 2023
Nicastro HL, Vorkoper S, Sterling R, Korn AR, Brown AGM, Maruvada P, Oh AY.   +6 more
europepmc   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

The halfway mark in our five-year strategic plan: How are we doing? [PDF]

Can Urol Assoc J, 2022
Razvi H.
europepmc   +1 more source

Information Services Strategic Plan 2017-2020 [PDF]

, 2017
Hisle, W. Lee
core   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Industry 4.0 readiness and strategic plan failures in SMEs: A comprehensive analysis. [PDF]

PLoS One
Techanamurthy U, Iqbal MS, Abdul Rahim Z.   +2 more
europepmc   +1 more source

The second strategic plan of medical ethics: a national report. [PDF]

J Med Ethics Hist Med, 2021
Parsapour A, Shamsi Gooshki E, Malekafzali H, Zahedi F, Larijani B.   +4 more
europepmc   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Epidemiology in health policies, programs, and services in Brazil: The trajectories and perspectives from ABRASCO's Fifth Strategic Plan for the Development of Epidemiology in Brazil (2025-2029). [PDF]

Rev Bras Epidemiol
Magno L, Oliveira LR, Donalísio MR, Gibson G, Valente BCS, Krüger A, Matos SMA, Teixeira MDG, Ramos Junior AN.   +8 more
europepmc   +1 more source

US-European and ASEAN strategic plan on COVID-19: a proposed multilateral diplomacy. [PDF]

J Public Health (Oxf), 2022
Cardenas NC.
europepmc   +1 more source