Results 81 to 90 of about 135,944 (267)

MagmaFlow: A desktop platform for artificial intelligence‐driven expression analysis

FEBS Open Bio, EarlyView.
MagmaFlow is a free, no‐code platform for gene expression analysis. It generates interactive volcano plots, links genes to literature, pathways, and diseases, prioritizes candidates using millions of publications, identifies affected biological processes, builds network diagrams, and exports publication‐ready figures and reports for macOS and Windows ...
Carlos E. Buss, Ao Li, Eduardo H. Gilglioni, Mayank Bansal, Sumeet Pal Singh, Latifa Bakiri, Alessandra K. Cardozo, Esteban N. Gurzov   +7 more
wiley   +1 more source

Ionomycin suppresses cancer cell growth by disrupting mitochondrial transcription

FEBS Open Bio, EarlyView.
In this study, we identify a new function for the selective Ca2+ ionophore, ionomycin, as an inhibitor of mitochondrial transcription. Both total and nascent RNA analyses revealed that ionomycin treatment reduces the transcription of mitochondrial genes.
Lishen Wang, Mingqiang Deng, Dongmei He, Diqin Lai, Dongjun Liu, Dengyong Zhu, Zhenhua Zhang, Peng Tang, Chuanman Zhou, Menghui Yin, Xichen Bao   +10 more
wiley   +1 more source

Identifying and modeling the dimensions of the university's relationship with the external environment from the perspective of ecosystem thinking with the grounded theory method and ISM [PDF]

سیاست نامه علم و فناوری
The lack of correct relationship between the university and the external environment (including society, industry, government, etc.) has been and is one of the current social issues of universities.
Mohammad Shamsoddini, Mohsen Miri, Hamed Najjaran Toosi, Ali Taheri   +3 more
doaj  

Exploring the influence of lactoferrin on wound healing and related signaling pathways: a systematic review

FEBS Open Bio, EarlyView.
Lactoferrin promotes wound healing by activating MAPK, PI3K/Akt, and extracellular matrix pathways, enhancing fibroblast remodeling, proliferation, and re‐epithelialization. These mechanisms highlight its therapeutic potential in inflammation control, tissue repair, and remodeling.
Morgana Lüdtke Azevedo, Kátia Cristiane Hall, Matheus dos Santos Fernandez, Geovanna Peter Corrêa, Rafael Guerra Lund   +4 more
wiley   +1 more source

Analysis of HERV-K (HML2) Expression in Colorectal Cancer Samples

Epigenomes
Background: HML-2 subgroup mobile genetic elements of the HERV-K family were described to participate in carcinogenesis processes, but their expression and epigenetic regulation in molecular subtypes of colorectal cancer (CRC) remain partly characterized.
Valentina S. Obrezanenko, Polina M. Shulga, Anastasia G. Volkova, Anastasia A. Primova, Yulia A. Remizova, Ivan O. Meshkov, Alexandra D. Kikot, Daria A. Tarasova, Ekaterina S. Bolashova, Alexey A. Ivashechkin, Antonida V. Makhotenko, Ekaterina A. Snigir, Yulia A. Masyukova, Elizaveta I. Radion, Olesya A. Kuznetsova, Maria S. Cheporova, Michail Y. Fedyanin, Alexey A. Tryakin, Valentin V. Makarov, Vladimir S. Yudin, Anton A. Keskinov, Anna S. Makarova   +21 more
doaj   +1 more source

Dual native G‐quadruplex folding is associated with chromatin looping at the MYC locus

FEBS Open Bio, EarlyView.
BG4‐detectable G‐quadruplex (G4) in HaCaT and NHEK keratinocytes identified folded and unfolded G4s enriched at promoters/TSSs and active enhancers, whereas unfolded G4s also overlapped weak/poised enhancers. At MYC–PVT1, 3C‐qPCR detected enhancer–promoter looping only when G4s were simultaneously folded at both regulatory elements under native ...
Dieila Giomo de Lima, Gustavo Narvaes Guimarães, Emilyane de Oliveira Santana Amaral, Bianca Caroline Figueiredo Bianco, Manuel Jara‐Espejo, Sérgio Roberto Peres Line, Ana Paula de Souza, Aline Cristiane Planello   +7 more
wiley   +1 more source

Towards More Equitable Urban Greening: A Framework for Monitoring and Evaluating Co-Governance

Urban Planning
Urban greening has grown in significance in Europe and worldwide as a presumed “public good” initiative, delivering a range of benefits for human health and wellbeing.
Eleanor Chapman, Viktor Bukovszki, Martina van Lierop, Silvia Tomasi, Stephan Pauleit   +4 more
doaj   +1 more source

From patient advocacy to patient‐driven research: Building active partnerships beginning at the bench to reach the bedside

FEBS Open Bio, EarlyView.
Research is strongest when conducted alongside patients, not just about them. Patient research organizations help integrate patient perspectives into research priorities, study design, and scientific meetings, leading to meaningful patient outcomes and development of relevant therapies.
Jenica H. Kakadia, Rachel Heilmann, Maximiliano Barrientos, Laura MacNeill, Ingrid Vallee, Sarah K. Schultz, Patrick O'Donoghue, Angelica A. Moresco, Victoria M. Siu, Ilka U. Heinemann   +9 more
wiley   +1 more source

Enhancing Patient Safety and Charge Capture Through Smart Infusion Pump Interoperability: A Health Economic Analysis for US Health Systems

ClinicoEconomics and Outcomes Research
Eric P Borrelli,1 Ashley Taneja,2 Shafiq Abdallah,2 Mia Weiss,2 Nicole S Wilson,3 Idal Beer,3 Julia D Lucaci2 1Health Economics and Outcomes Research, MMS, Becton, Dickinson and Company, San Diego, CA, USA; 2HEOR Strategic Planning, Becton, Dickinson and
Borrelli EP, Taneja A, Abdallah S, Weiss M, Wilson NS, Beer I, Lucaci JD   +6 more
doaj  

BCG vaccination potentiates oxidative phosphorylation in neonatal myeloid‐derived suppressor cells

FEBS Open Bio, EarlyView.
BCG vaccination enhances oxidative phosphorylation in neonatal MDSCs, impairing their immunosuppressive function. It upregulates electron transport chain genes and mitochondrial activity, increasing ATP and oxygen consumption. Pharmacological OXPHOS inhibition partially restores suppressive capacity, confirming causality.
Yingying Chen, Hui Li
wiley   +1 more source