Results 161 to 170 of about 85,146 (246)

DeepRetro discovers retrosynthetic pathways through iterative large language model reasoning. [PDF]

Sci Rep
Sathyanarayana SV, Hiremath SD, Rahil Kirankumar S, Panda R, Jana R, Singh R, Irfan R, Murali A, Ramsundar B.   +8 more
europepmc   +1 more source

Multi‐omics and low‐input proteomics profiling reveals dynamic regulation driving pluripotency initiation in early mouse embryos

FEBS Open Bio, EarlyView.
Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li, Xi Xiao, Lingbin Qi, Chanyi Li, Sirui Song, Jiaying Qin, Zhigang Xue, Jinfeng Xue, Huaifang Li   +8 more
wiley   +1 more source

Does fluralaner (Exzolt^® 5%) affect the enzootic stability of tick fever in beef calves subjected to strategic tick control in a tropical region? [PDF]

Parasit Vectors
de Aquino LM, de Morais IML, Salvador VF, Leal LLLL, Ribeiro NB, Heller LM, Tamiozo GL, Bittencourt RBM, de Lima NJ, Ferreira LL, de Castro Rodrigues D, Strydom T, Torres S, Soares VE, de Oliveira Monteiro CM, da Silva Krawczak F, Lopes WDZ.   +16 more
europepmc   +1 more source

HIV‐1 establishes immediate latency in T cells expressing the viral Nef protein

FEBS Open Bio, EarlyView.
Nef is a viral protein often omitted from HIV‐1 reporter viruses. Consequently, its role in viral latency is unclear. We developed three novel dual reporter HIV‐1 derivatives that express Nef and allow for detection of latent and productive infection. Using these reporters, we show that Nef does not affect the establishment of immediate viral latency ...
Cindy Lam, Ivan Sadowski
wiley   +1 more source

Quantum-enhanced hybrid deep reinforcement learning for real-time volleyball tactical decision making. [PDF]

Sci Rep
Cai N, Zhao M, Ke Y, Liu X.
europepmc   +1 more source

BMI‐1 modulation and trafficking during M phase in diffuse intrinsic pontine glioma

FEBS Open Bio, EarlyView.
The schematic illustrates BMI‐1 phosphorylation during M phase, which triggers its translocation from the nucleus to the cytoplasm. In cycling cells, BMI‐1 functions within the PRC1 complex to mediate H2A K119 monoubiquitination. Following PTC596‐induced M phase arrest, phosphorylated BMI‐1 dissociates from PRC1 and is exported to the cytoplasm via its
Banlanjo Umaru, Deepak Kumar Mishra, Shiva Senthil Kumar, Hao‐Han Pang, Brendan Devine, Komal Khan, Rachid Drissi   +6 more
wiley   +1 more source

Diagnostic Value of Serum p-tau217 in Alzheimer Disease: Equal to Plasma in Levels and Clinical Utility? [PDF]

Clin Chem
Benedet AL, Arslan B, Tan K, Huber H, Pola I, Di Molfetta G, Kvartsberg H, Dolado AO, Janelidze S, Blennow K, Zetterberg H, Hansson O, Rosa-Neto P, Ashton NJ.   +13 more
europepmc   +1 more source

Meta‐analysis fails to show any correlation between protein abundance and ubiquitination changes

FEBS Open Bio, EarlyView.
We analyzed over 50 published proteomics datasets to explore the relationship between protein levels and ubiquitination changes across multiple experimental conditions and biological systems. Although ubiquitination is often associated with protein degradation, our analysis shows that changes in ubiquitination do not globally correlate with changes in ...
Nerea Osinalde, Unai Alduntzin, Gorka Prieto, Ugo Mayor   +3 more
wiley   +1 more source

Regional health security architecture in ASEAN countries: Lessons from regional CDC models and Japan's strategic partnership for ACPHEED development. [PDF]

Glob Health Med
Miyano S, Nozaki I, Hachiya M, Miyamoto T, Takei T.   +4 more
europepmc   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source