Results 91 to 100 of about 910,791 (289)

Application of Physiologically Based Pharmacokinetic Modeling in Preclinical Studies: A Feasible Strategy to Practice the Principles of 3Rs. [PDF]

Front Pharmacol, 2022
Yuan Y, He Q, Zhang S, Li M, Tang Z, Zhu X, Jiao Z, Jiao Z, Cai W, Xiang X.   +9 more
europepmc   +1 more source

Liquid Hydroxyurea (Xromi) for Children With Sickle Cell Anemia: A New Solution Compounding Existing Problems

Pediatric Blood &Cancer, EarlyView.
Alexandra Power‐Hays, Charles T. Quinn
wiley   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Unlocking lock-in. Emergence, perpetuation and decline of regional entrepreneurship in transitional societies: examples from contemporary Polandstrategy-as-practice

Rozwój Regionalny i Polityka Regionalna
This paper examines how the phenomenon of lock-in can initially stimulate entrepreneurship and path creation in transitional societies but eventually impede municipal development.
Grzegorz Simborowski, Paweł Kłobukowski   +1 more
doaj   +1 more source

An intracellular transporter mitigates the CO2‐induced decline in iron content in Arabidopsis shoots

FEBS Letters, EarlyView.
This study identifies a gene encoding a transmembrane protein, MIC, which contributes to the reduction of shoot Fe content observed in plants under elevated CO2. MIC is a putative Fe transporter localized to the Golgi and endosomal compartments. Its post‐translational regulation in roots may represent a potential target for improving plant nutrition ...
Timothy Mozzanino, Meijie Li, Cécile Fizames, Mattia Adamo, Laurence Lejay, Christian Dubos, Matthieu Platre, Antoine Martin   +7 more
wiley   +1 more source

Strategists in an uncertain world [PDF]

Referring to the conceptual framework for strategy-as-practice (Whittington 2006, Jarzabkowski et al. 2007), this paper aims at investigating the practioners-practices couple, by analysing the main and recurrent individual characteristics of ...
Christophe Torset, Stéphanie Dameron
core  

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

FEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo, Catherine S. Palmer, Jacqueline M. Kimmey   +2 more
wiley   +1 more source

An analysis of the environment and competitive dynamics of management research [PDF]

, 2009
Purpose – The purpose of this paper examines some of the controversies facing business schools in their future evolution and pays particular attention to their competitive positioning as centres of management research.
Alex Wilson, Eric Cornuel, Howard Thomas
core   +2 more sources

Open Innovation and Open Strategy from the perspective of Strategy as Practice: a theoretical essay

Revista Eletrônica de Ciência Administrativa
Open Strategy (OS) has emerged as a phenomenon that has allowed organizations to adapt to the concept that incorporates Open Innovation (OI) practices with a focus on greater transparency and inclusion in strategy formation processes.
Maria Luciana Trigos, Rosalia Aldraci Barbosa Lavarda   +1 more
doaj   +1 more source

Hematopoietic (stem) cells—The elixir of life?

FEBS Letters, EarlyView.
The aging of HSCs (hematopoietic stem cells) and the blood system leads to the decline of other organs. Rejuvenating aged HSCs improves the function of the blood system, slowing the aging of the heart, kidney, brain, and liver, and the occurrence of age‐related diseases.
Emilie L. Cerezo, Jonah Anderson, Emilie Dinh Vedrenne, Noël Yeh Martín, Jette Lengefeld   +4 more
wiley   +1 more source