Results 71 to 80 of about 988,232 (246)
Rozwój Regionalny i Polityka RegionalnaThis paper examines how the phenomenon of lock-in can initially stimulate entrepreneurship and path creation in transitional societies but eventually impede municipal development.
Grzegorz Simborowski +1 more
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FEBS Letters, EarlyView.Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai +4 more
wiley +1 more source
Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations
FEBS Letters, EarlyView.The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas +6 more
wiley +1 more source
Open Innovation and Open Strategy from the perspective of Strategy as Practice: a theoretical essay
Revista Eletrônica de Ciência AdministrativaOpen Strategy (OS) has emerged as a phenomenon that has allowed organizations to adapt to the concept that incorporates Open Innovation (OI) practices with a focus on greater transparency and inclusion in strategy formation processes.
Maria Luciana Trigos +1 more
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FEBS Letters, EarlyView.An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley +1 more source
FEBS Letters, EarlyView.The physical dimensions and shape of bacterial cells define the surface area available to acquire nutrients and the volume available for synthesizing proteins and DNA. Here, we use computational systems biology to decode the importance of cell geometry as a major determinant of prokaryotic phenotype, including growth rate and metabolic efficiency. This
Ross P. Carlson +6 more
wiley +1 more source
From Strategy to Practice [PDF]
, 2017 Strategic reversals are quite commonly failures of execution. In many cases, a strategy is abandoned out of impatience or because of pressure for an instant payoff before it has had a chance to take root and yield results. Or its focal point is allowed to drift over time.
openaire +1 more source
Strategies and practical examples [PDF]
European Journal of Public Health, 2019 Abstract Various tools and mechanisms can help to increase the use of scientific evidence in policy development by making policymakers appreciate, understand and incorporate such scientific information into policy decisions. As part of this process, it is crucial that researchers and public health practitioners acquire the ability to ...
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FEBS Letters, EarlyView.Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley +1 more source
Contornando o Estigma: uma análise dos estúdios de tatuagens em Belo Horizonte
Teoria e Prática em Administração, 2014 Small businesses are vital to the economy, contributing to PIB and to job creation. Howerver, most part of these businesses have difficult to survive, what reveals problems in theirs managament processes.
Silva, Alexsandra Nascimento da +1 more
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