Results 101 to 110 of about 11,624,639 (349)
FEBS Letters, EarlyView.In this work, we reveal how different enzyme binding configurations influence the fluorescence decay of NAD(P)H in live cells using time‐resolved anisotropy imaging and fluorescence lifetime imaging microscopy (FLIM). Mathematical modelling shows that the redox states of the NAD and NADP pools govern these configurations, shaping their fluorescence ...
Thomas S. Blacker +8 more
wiley +1 more source
Strategy and its discontents: the place of strategy in national policymaking [PDF]
This paper presents a collection of views about the definition, role, purpose and health of strategic policymaking. Introduction One of the liveliest debates to have taken place on ASPI’s blog, The Strategist, concerned the place of strategy in ...
Anthony Bergin +7 more
core
Neutrophil deficiency increases T cell numbers at the site of tissue injury in mice
FEBS Letters, EarlyView.In wild‐type mice, injury or acute inflammation induces neutrophil influx followed by macrophage accumulation. Mcl1ΔMyelo (neutrophil‐deficient) mice lack neutrophils, and in response to muscle injury show fewer macrophages and exhibit strikingly elevated T‐cell numbers, primarily non‐conventional “double‐negative” (DN) αβ and γδ T cells.
Hajnalka Halász +6 more
wiley +1 more source
Identifying one university’s prevailing online course accessibility issues
Educational Technology & SocietyOnline and digital learning is becoming more widespread in a post-pandemic world. The rapid expansion of online education has introduced many accessibility concerns that may go unnoticed by inexperienced observers.
Madasen Briggs +4 more
doaj +1 more source
Development of visible light‐sensitive human neuropsin (OPN5) via single amino acid substitution
FEBS Letters, EarlyView.The present study determines a key amino acid residue, Lys91, for defining UV sensitivity of human OPN5. Heterologous action spectroscopy of the wild type and K91 mutants of OPN5 in HEK293T cells reveals that substitution of Lys91 with neutral (alanine) or acidic amino acids (glutamic or aspartic acids) causes substantial shifts in spectral sensitivity
Yusuke Sakai +2 more
wiley +1 more source
Information and Control, 1982 One interesting suggestion in selecting natural against nonnatural languages is that children master a language by selecting a grammar for it from an innately determinated class of candidates. It is the learning strategy to which the child conforms that determines the subset of innate grammars that can be successfully paired with incoming languages ...
Osherson, Daniel N. +2 more
openaire +2 more sources
Exploring lipid diversity and minimalism to define membrane requirements for synthetic cells
FEBS Letters, EarlyView.Designing the lipid membrane of synthetic cells is a complex task, in which its various roles (among them solute transport, membrane protein support, and self‐replication) should all be integrated. In this review, we report the latest top‐down and bottom‐up advances and discuss compatibility and complexity issues of current engineering approaches ...
Sergiy Gan +2 more
wiley +1 more source
Donor Advisors and Philanthropic Strategy [PDF]
, 2008 Based on a literature review and interviews, explores how donor advisors shape the philanthropic strategies of the wealthy. Looks at the key activities and elements of effective advising, the need for training, and the potential for ...
Lilli Friedland, Thomas E. Backer
core
FEBS Letters, EarlyView.C‐mannosylation is a unique form of protein glycosylation. In this study, we demonstrated that ADAMTS1 is C‐mannosylated at Trp562 and Trp565 in human testicular germ cell tumor NEC8 cells. We found that C‐mannosylation of ADAMTS1 is essential for its secretion, processing, enzymatic activity, and ability to promote vasculogenic mimicry. These findings
Takato Kobayashi +5 more
wiley +1 more source