Results 61 to 70 of about 397,778 (284)
Molecular Oncology, EarlyView.We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto +8 more
wiley +1 more source
Next‐generation proteomics improves lung cancer risk prediction
Molecular Oncology, EarlyView.This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj +4 more
wiley +1 more source
Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib
Molecular Oncology, EarlyView.WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute +17 more
wiley +1 more source
Molecular Oncology, EarlyView.The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola +12 more
wiley +1 more source
Remotely sensed data controlled forest inventory concept
European Journal of Remote Sensing, 2018 Nowadays, the image of the forest in Germany is changing from monoculture areas to very mixed forests, where individual stands are no longer clearly visible.
Adelheid Wallner +5 more
doaj +1 more source
Observed and predicted first lactation milk yield in Surti buffaloes
Indian Journal of Animal Sciences, 2014 305FLMY was predicted from fortnightly, monthly and bimonthly test day milk yields using 2 sampling schemes (systematic and stratified random sampling) in Surti buffaloes maintained at Network Project on Surti buffaloes, Livestock Research Station ...
S P TAILOR, SHANKER SINGH
doaj +1 more source
Aquaculture and Fisheries, 2020 Stratified random survey is commonly used to estimate abundance indices of fish populations in multispecies survey, providing reliable data for stock assessment and fisheries management. In some cases, however, the sample size is relatively small because
Guosheng Zhang +6 more
doaj +1 more source
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
A new modified estimator of population variance in calibrated survey sampling
Scientific ReportsIn survey statistics, estimating and reducing population variation is crucial. These variations can occur in any sampling design, including stratified random sampling, where stratum weights may increase the variance of estimators. Calibration techniques,
Riffat Jabeen +4 more
doaj +1 more source
Progress in Fishery SciencesBiodiversity assessment in fisheries plays a crucial role in conserving marine ecosystem diversity. Accurate survey data serve as the foundation for ensuring the precision of quantitative analysis and the effectiveness of resource conservation measures ...
Yuexiu DENG +5 more
doaj +1 more source