PDE4 Inhibition in Dermatologic Disease: Impacts Beyond Inflammation
This graphical abstract demonstrates the comprehensive mechanism of PDE4 inhibition in skin physiology. By increasing intracellular cAMP and activating PKA, PDE4 inhibitors exert pleiotropic effects, including immune modulation, pigmentation regulation, barrier enhancement, sensory neuron modulation, and improved wound healing with reduced fibrosis ...
Keana Khodadad +2 more
wiley +1 more source
Investigating the Effect of Enzymatically-Derived Blackcurrant Extract on Skin Staphylococci Using an In Vitro Human <i>Stratum Corneum</i> Model. [PDF]
Ćorović M +8 more
europepmc +1 more source
Solubility of Foreign Molecules in Stratum Corneum Brick and Mortar Structure. [PDF]
Pham QD +4 more
europepmc +1 more source
Delphi‐based expert consensus for diagnosis and management of common hyperpigmentation disorders in Indian dermatology practice, integrating evidence review, iterative voting, and consensus‐driven recommendations. ABSTRACT Hyperpigmentation disorders are prevalent in individuals with skin of color and are associated with considerable psychosocial ...
Rashmi Sarkar +12 more
wiley +1 more source
Stratum corneum hydration levels are negatively correlated with HbA1c levels in the elderly Chinese. [PDF]
Lai Q +7 more
europepmc +1 more source
Deep and disseminated dermatophytosis in immunocompromised populations—A systematic review
Dermatophyte infections of the dermis and subcutaneous tissue (i.e. deep dermatophytosis)—associated with secondary complications including pseudomycetoma and systemic dissemination—affect vulnerable populations with primary or acquired immunodeficiencies.
Aditya K. Gupta +5 more
wiley +1 more source
New Skin-Relevant Cell Coculture Model With Stratum Corneum-Like Layer. [PDF]
Quijas G +3 more
europepmc +1 more source
Unlocking the Stratum Corneum Barrier to Skin Penetration for the Transdermal Delivery of Cyclovirobuxine D. [PDF]
Ren YH +4 more
europepmc +1 more source
Darier disease—A review highlighting new insights from the Darier Disease International Task Force
This review provides a global, clinically focused overview of DD, detailing cutaneous and extracutaneous manifestations, disease classification and severity scoring. It emphasizes early recognition, multidisciplinary management and practical guidance for dermatologists to apply evidence‐based care in diverse skin phototypes. Abstract Darier disease (DD)
Sofia Labbouz +49 more
wiley +1 more source
Establishing a General Atomistic Model for the Stratum Corneum Lipid Matrix Based on Experimental Data for Skin Permeation Studies. [PDF]
Radhakrishnan N +4 more
europepmc +1 more source

