Results 191 to 200 of about 87,981 (309)

Modulation of sebocyte function in acne: A pathway‐inclusive review

Journal of the European Academy of Dermatology and Venereology, EarlyView.
Acne is multifactorial, with the sebocyte acting as a central immunometabolic hub linking lipogenic, inflammatory, hormonal and barrier pathways. Mapping established and investigational therapies onto this sebocyte‐centred model offers a mechanism‐based framework that complements existing treatment paradigms and may guide more targeted, antibiotic ...
Christos C. Zouboulis, Apostolos Pappas, Katja Martin, Mauro Picardo   +3 more
wiley   +1 more source

The Impact of Age on the Lipidomic Profile of the Stratum Corneum and Associated Effects on Structure, Function and Overall Skin Health in Adults Predisposed to Atopic Dermatitis. [PDF]

Exp Dermatol
Williams SF, Andrew P, Brown K, Chittock J, Pinnock A, Poyner A, Cork MJ, Danby SG.   +7 more
europepmc   +1 more source

Hidradenitis suppurativa skin microbiome: In‐depth analysis and modulation by systemic therapies

Journal of the European Academy of Dermatology and Venereology, EarlyView.
Hidradenitis suppurativa skin exhibits profound dysbiosis, characterized by the depletion of homeostatic commensals and expansion of anaerobic pathogens. Longitudinal evaluation reveals that while systemic antibiotics successfully reverse HS dysbiosis, biologics (adalimumab and secukinumab) fail to clear pathogens despite clinical healing.
Yacine Amar, Diana Baumann, Sebastian Niedermeier, Rafaela L. Silva, Susanne Walch, Michael Schloter, Martin Köberle, Tilo Biedermann, Thomas Volz   +8 more
wiley   +1 more source

Impacts of Topical Treatments and Phototherapy on Stratum Corneum Hydration, Sebum and Elasticity in Vitiligo Skin. [PDF]

Dermatol Ther (Heidelb)
Wen Y, Issa IA, Lei L, Fu C, Zhou S, Zhang K, Huang J, Chen J, Zeng Q, Jiang L.   +9 more
europepmc   +1 more source

Myeloid A20 Regulates Periodontal Tissue Integrity and Temporomandibular Joint Structure

Journal of Periodontal Research, EarlyView.
Dysregulation of A20 signaling has been implicated in several immune‐mediated diseases, including rheumatoid arthritis and psoriasis, conditions characterized by excessive NF‐κB activation and inflammatory tissue damage. The structural alterations observed in this model suggest that impaired regulation of innate immune signaling may increase ...
Karol Alí Apaza Alccayhuaman, Patrick Heimel, Toni Dobsak, Stefan Tangl, Geert van Loo, Dieter D. Bosshardt, Reinhard Gruber   +6 more
wiley   +1 more source

Skin-Protective Performance of Alternative Stratum Corneum Formed by a Pseudo-Ceramide-Containing Steroid Lamellar Cream. [PDF]

Exp Dermatol
Yokota M, Matsumoto T, Kawamoto A, Dojo K, Toyama S, Moniaga CS, Ishikawa J, Murase D, Ota N, Tominaga M, Takamori K.   +10 more
europepmc   +1 more source

Stratum Corneum Interleukin-2 in Facial Eczema at 1-Month-Old Predicts Later Atopic Dermatitis. [PDF]

Allergy
Maehara E, Kido-Nakahara M, Fujita Y, Kato K, Kido S, Yamasaki R, Nagata S, Kishimoto J, Watanabe H, Harada E, Nagashima Y, Umeno E, Tsuji G, Esaki H, Nakahara T.   +14 more
europepmc   +1 more source

Cis‐urocanic acid formation following far‐UVC exposure and associated signaling responses in keratinocytes

Photochemistry and Photobiology, EarlyView.
Far‐UVC (200–235 nm) has emerged as a safe and effective indoor disinfection tool, but effects on skin immunomodulation remain unclear. This study demonstrates that 222 nm far‐UVC converts trans‐urocanic acid (UCA) to its biologically active cis isomer at levels comparable with solar radiation. In keratinocytes, far‐UVC alone caused modest increases in
Lizzie Thomas, Gareth Hazell, Katarzyna Baczynska, Jinkang Zhang, Paul O'Mahoney   +4 more
wiley   +1 more source

Effect of Application of Ultrafine Water Droplets on Water Content in the Stratum Corneum Layer in Excised Human Skin and on Barrier Function in a Three-Dimensional Cultured Human Skin Model. [PDF]

Skin Res Technol
Todo H, Hirota M, Kage M, Takagi Y, Narita I, Inoue S, Tabata Y, Yokoyama K, Itakura S, Komatsu S.   +9 more
europepmc   +1 more source

Development of chalcones structure‐related to avobenzone: Photoprotection, photostability, and safety evaluation

Photochemistry and Photobiology, EarlyView.
Scaffold hopping strategy used to develop chalcones structure‐related to the avobenzone tautomer. Positive aspects of 2‐hydroxychalcones are highlighted. Abstract Chalcones are α,β‐unsaturated ketones with extended π‐conjugation, making them promising scaffolds for the development of organic UV filters.
Gabriela Zanella Marcon, Taíne de Bastos Brum, Nayara Fernanda Tokashike de Araujo, Gabriela Lascala Ramos, Bruna Cogo Borin, Ruth Barin, Aline Ferreira Ourique, André Passaglia Schuch, Andréa Inês Horn Adams, Lorena Rigo Gaspar Cordeiro, Letícia Cruz, Fernando Fumagalli   +11 more
wiley   +1 more source