A double‐Cox model for non‐proportional hazards survival analysis with frailty
The Cox regression, a semi‐parametric method of survival analysis, is extremely popular in biomedical applications. The proportional hazards assumption is a key requirement in the Cox model. To accommodate non‐proportional hazards, we propose to parameterize the shape parameter of the baseline hazard function using the additional, separate Cox ...
Alexander Begun +2 more
wiley +1 more source
Resistance training does not increase myocellular garbage dumps: A pilot study on lipofuscin in skeletal muscle fibers of resistance trained young men. [PDF]
Abstract Lipofuscin (LF) is an intracellular aggregate associated with proteostatic impairments, especially prevalent in nondividing skeletal muscle fibers. Reactive oxygen species (ROS) drive LF‐formation. Resistance training (RT) improves muscle performance but also increases ROS production, potentially promoting LF‐formation.
Jacko D +7 more
europepmc +2 more sources
Abstract We optimized a high throughput method to quantify turnover rates of adenosine triphosphate (ATP), adenosine diphosphate (ADP), and adenosine monophosphate (AMP) in marine microbes from simultaneous measures of the respective stocks and phosphorylation rates.
Kaycie B. Lanpher, Kimberly J. Popendorf
wiley +1 more source
Circadian and diel regulation of photosynthesis in the bryophyte Marchantia polymorpha
Abstract Circadian rhythms are 24‐h biological cycles that align metabolism, physiology, and development with daily environmental fluctuations. Photosynthetic processes are governed by the circadian clock in both flowering plants and some cyanobacteria, but it is unclear how extensively this is conserved throughout the green lineage.
David Cuitun‐Coronado +5 more
wiley +1 more source
The metabolome as a biomarker of aging in Drosophila melanogaster
Age‐specific metabolome‐wide profiles of Drosophila melanogaster are highly correlated with sample age. In this study, we build a metabolome clock to measure age acceleration, the difference between predicted sample age and chronological age, and show that this can predict mortality risk and lifespan outcome. Abstract Many biomarkers have been shown to
Xiaqing Zhao +9 more
wiley +1 more source
Abstract The use of adenosine triphosphate (ATP) as a universal biomass indicator is built on the premise that ATP concentration tracks biomass rather than the physiological condition of cells. However, reportedly high variability in ATP in response to environmental conditions is the main reason the method has not found widespread application.
Alexander B. Bochdansky +2 more
wiley +1 more source
La présence de la lumière strehlerienne en France
La lumière, Strehler a su en faire une composante fondamentale de ses spectacles, la développant d’une manière tout à fait personnelle qui est devenue très vite une référence pour beaucoup de metteurs en scène.
Antonio Palermo
doaj +1 more source
Reviewers acknowledgement [PDF]
FEBS Open Bio, Volume 15, Issue 12, Page 2096-2099, December 2025.
europepmc +2 more sources
«Io ho bisogno di animali teatrali»
«It is not enough that they sing well [...]. I need theatrical animals». So, Giorgio Strehler, in 1997, gave indications to the musicologist Carlo de Incontrera for the distribution of Così fan tutte, a production that in his own mind should have marked
Matteo Paoletti
doaj +1 more source
"Naturalization" of Routine Assisted Reproductive Technologies by In Vitro Culture of Embryos with Microvibration: Sex Ratio, Body Length, and Weight of 2,456 Live-Birth Deliveries after Transfer of 9,624 Embryos In Vitro Cultured in Static System and with Microvibration. [PDF]
Aim was to determine whether there is any difference in the sex ratio, body length, and body weight of 2,456 deliveries after transfer of 9,624 embryos derived using in vitro culture under static and mechanical microvibration conditions. Pronuclear embryos from 4435 patients were cultured in vitro under two different conditions: without (n = 4821) and ...
Isachenko V +10 more
europepmc +2 more sources

