Results 81 to 90 of about 8,104,821 (348)

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

FEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf, Nicholas F. Downing, Kaitlyn M. Mills, Samuel C. Metcalfe, Alexander E. Kritzer, Lindsey D. Mayo, Peter C. Hollenhorst   +6 more
wiley   +1 more source

Calculation and analysis of heat generation of aero-engine bearing-support system

Hangkong gongcheng jinzhan
The heat source analysis and quantitative calculation of heat production of the bearing-support structure system can provide a reliable basis for the thermal protection design of the bearing cavity.
SUN Peng, MU Qinqin, CHEN Yonghui, YAN Qun   +3 more
doaj   +1 more source

Quantifying Bar Strength: Morphology Meets Methodology

, 2004
A set of objective bar-classification methods have been applied to the Ohio State Bright Spiral Galaxy Survey (Eskridge et al. 2002). Bivariate comparisons between methods show that all methods agree in a statistical sense.
BG Elmegreen, DL Block, G Vaucouleurs, H Wozniak, HD Curtis, JA Hackwell, PB Eskridge, PB Eskridge, R Buta, SC Odewahn   +9 more
core   +2 more sources

Characterizing the salivary RNA landscape to identify potential diagnostic, prognostic, and follow‐up biomarkers for breast cancer

Molecular Oncology, EarlyView.
This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan, Irina Primac, Emre Etlioglu, Laurens Debruyne, Ann Janssen, Magy Sallam, Kevin Tabury, Roel Quintens, Wiebren Tjalma, Mohammed Abderrafi Benotmane   +9 more
wiley   +1 more source

Random Vibration Fatigue Life Analysis of Aeroengine Bolts Using the Frequency-Domain Method

Fatigue of Aircraft Structures
Bolt connections are widely used in aircraft engines due to their advantages of high stiffness, low weight, and ease of assembly and disassembly. However, they are subjected to complex stress states in service, including high preloads, combustion-induced
Tian Lilin, Wang Jun, Zhang Chaofeng, Guo Yuchao, Chang Liang   +4 more
doaj   +1 more source

Optimum Selection Analysis of Composite Cap Cone

Engineering Proceedings
An in-depth analysis was conducted on the dynamic strength design optimization of carbon fiber composite cap cones in aircraft engines subjected to bird body impacts. Initially, the top, 1/4, 1/2, 3/4, and root positions of the cap cone’s generatrix were
Jijun Liu, Yongping Jiang, Kaixiang Li, Yafeng Wang   +3 more
doaj   +1 more source

Acoustic emission characterization of sliding wear under condition of direct and inverse transformations in low-temperature degradation aged Y-TZP and Y-TZP-AL2O3

Friction, 2018
In this research, results of the investigation of the sliding friction and wear of yttria-stabilized tetragonal zirconia polycrystalline (Y-TZP) and Y-TZP-Al2O3 samples preliminarily subjected to low-temperature degradation are reported.
Nikolai L. Savchenko, Andrey V. Filippov, Sergei Yu Tarasov, Andrey I. Dmitriev, Evgeny V. Shilko, Aleksandr S. Grigoriev   +5 more
doaj   +1 more source

Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology

Molecular Oncology, EarlyView.
Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts, Senada Koljenović, Elise Daems, Karolien De Wael, Marc Peeters, Léon C. van Kempen, Greetje Vanhoutte, Karen Zwaenepoel, Timon Vandamme   +8 more
wiley   +1 more source

Ground Strength Test Technique of Variable-Camber Wing Leading Edge

Biomimetics
Morphing wing technology is crucial for enhancing the flight performance of aircraft. To address the monitoring challenges of full-scale variable-camber leading edges under flight conditions, this study introduces a ground-based strength testing ...
Shanshan Li, Xianmin Chen, Zhigang Wang, Yuanbo Liang   +3 more
doaj   +1 more source

Gut microbiota diversity is prognostic in metastatic hormone receptor‐positive breast cancer patients receiving chemotherapy and immunotherapy

Molecular Oncology, EarlyView.
In this exploratory study, we investigated the relationship between the gut microbiota and outcome in patients with metastatic hormone receptor‐positive breast cancer, treated in a randomized clinical trial with chemotherapy alone or chemotherapy in combination with immune checkpoint blockade.
Andreas Ullern, Kristian Holm, Nikolai Kragøe Andresen, Andreas Hagen Røssevold, Corinna Bang, Bjørn Naume, Johannes R. Hov, Jon Amund Kyte   +7 more
wiley   +1 more source