Results 81 to 90 of about 6,309,861 (384)

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

Molecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia, Noelia Moares, Wenjie Yi‐He, Rosa Luna‐Espejo, Ricardo Fernandez‐Cisnal, Javier Ocaña‐Cuesta, Juan P. Muñoz‐Miranda, Antonio Gabucio, Cecilia M. Fernandez‐Ponce, Francisco Garcia‐Cozar   +9 more
wiley   +1 more source

Optimization of conditions for the formation of functional coatings based on carboxymethylcellulose with chromium [PDF]

ITM Web of Conferences
The possibility of increasing the strength and improving the functional properties of coatings based on biopolymers by adding metal powders is considered.
Antonova Natalia, Khokhlova Anna
doaj   +1 more source

Self-consistent Skyrme QRPA for use in axially-symmetric nuclei of arbitrary mass [PDF]

, 2010
We describe a new implementation of the quasiparticle random phase approximation (QRPA) in axially-symmetric deformed nuclei with Skyrme and volume-pairing energy-density functionals. After using a variety of tests to demonstrate the accuracy of the code
A. Bohr, A. Bohr, I. Z. Petkov, J. Engel, J. Terasaki, J.-P. Blaizot, P. Ring   +6 more
core   +3 more sources

Strength through diversity: how cancers thrive when clones cooperate

Molecular Oncology, EarlyView.
Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken, Maartje Witsen, Emile E. Voest, Krijn K. Dijkstra   +3 more
wiley   +1 more source

A Generic Method for the Reliable Calculation of Large- Scale Fading in an Obstacle-Dense Propagation Environment [PDF]

, 2013
The aim of this chapter is to summarize and present recent findings in the field of wireless channel mod- eling that provide a new method for the reliable calculation of the statistical parameters of large-scale variations of the average received ...
Babulak, E., Chrysikos, T., Kotsopoulos, S.   +2 more
core   +1 more source

Next‐generation proteomics improves lung cancer risk prediction

Molecular Oncology, EarlyView.
This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj, Clara Frick, Ben Schöttker, Bernd Holleczek, Hermann Brenner   +4 more
wiley   +1 more source

Research of the Calculation Method of Bending Strength of Non-orthogonal Helical Face Gear

Jixie chuandong, 2020
There is no analytical calculation method and formula for the calculation of the bending strength of the face gear.For this reason，based on the principle of tooth surface contact analysis，the formula for calculating the length of the bending arm is ...
Derun Qin, Long Yang, Jinyuan Tang, Siyu Chen   +3 more
doaj  

Nonlinear optical properties in a quantum well with the hyperbolic confinement potential

, 2011
We have performed theoretical calculation of the nonlinear optical properties in a quantum well (QW) with the hyperbolic confinement potential. Calculation results reveal that the transition energy, oscillator strength, second-order nonlinear optical ...
Baskoutas, Chakraborty, Chen, Dong, Kuhn, Leininger, Lu, Lu, Luo, Notomi, Peng, Quinn, Rosencher, Rosencher, Schiöberg, Shijun Liang, Singh, Tairong Chen, Tiwari, Tsirkin, Wang, Wenfang Xie, Williamson, Williamson, Xie, Zalużny, Zhang, Zhang   +27 more
core   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Static Strength Analysis and Test of Articulated Equipment of Suspended Modular Tram with 5 Modules

机车电传动, 2021
Tests and  finite element calculation methods were used to verify the structure and strength of the articulated equipment of the suspended modular tram with 5 modules and low  floor.
Xiongfang DENG, Baoming AN, Yuezhong CHEN   +2 more
doaj