Results 81 to 90 of about 1,451,944 (303)

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Fractal asymptotics

, 2003
Recent advances in the periodic orbit theory of stochastically perturbed systems have permitted a calculation of the escape rate of a noisy chaotic map to order 64 in the noise strength.
Berry, Bessis, Boyd, C.P Dettmann, Cvitanović, Cvitanović, Cvitanović, Dettmann, Dettmann, Dettmann, Gaspard, Palla, Saleur, Shafer   +13 more
core   +1 more source

Self-consistent Skyrme QRPA for use in axially-symmetric nuclei of arbitrary mass [PDF]

, 2010
We describe a new implementation of the quasiparticle random phase approximation (QRPA) in axially-symmetric deformed nuclei with Skyrme and volume-pairing energy-density functionals. After using a variety of tests to demonstrate the accuracy of the code
A. Bohr, A. Bohr, I. Z. Petkov, J. Engel, J. Terasaki, J.-P. Blaizot, P. Ring   +6 more
core   +3 more sources

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns, Jaclyn S. Long, Sergio Lilla, Kelly Hodge, Marcus J. G. W. Ladds, Colin Nixon, Paula Fernández‐Palanca, Sara Zanivan, Pilar Acedo, Stephen P. Pereira, Kevin M. Ryan   +10 more
wiley   +1 more source

Half-lives and pre-supernova weak interaction rates for nuclei away from the stability line [PDF]

, 1998
A detailed model for the calculation of beta decay rates of the $fp$ shell nuclei for situations prevailing in pre-supernova and collapse phases of evolution of the core of massive stars leading to supernova explosion has been extended for electron ...
A Ray, Aufderheide M B, Bethe H A, Draayer J P, Draayer J P, French J B, K Kar, Klapdor H V, Kota V K B, Kota V K B, S Chakravarti, S Sarkar, Takahashi K   +12 more
core   +3 more sources

Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer

Molecular Oncology, EarlyView.
COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann, Eduardo García‐Galea, Alice O'Farrell, Zak Kinsella, Maxime Meylan, Florent Petitprez, Ingrid Arijs, Tom Venken, Hari Ps, Adrian Lärkeryd, Ian Miller, Janick Selves, Nadja Meindl‐Beinker, Fiorella Ruiz‐Pace, Elena Élez, Raquel Comas‐Navarro, Frank Lincoln, Dirk Fey, Gift Nyamundanda, Aoife Nolan, Joern Lewin, Raquel Perez‐Lopez, Jonathan Briody, Kathleen Bennett, Walter Kolch, David Matallanas, Alexander Kel, Enrique Arenas, Joaquín Arribas, Bart Ghesquière, Josep Tabernero, Julie Meilleroux, Deborah McNamara, Ray McDermott, Marvin Lim, Mary O'Reilly, Brian Bird, Lisa Stack, Lucia Moloney, Patrick Morris, Keith Egan, Maciej Milewski, Lars Scheuer, Joachim Behringer, Georg Bolz, Ramon Salazar, Cristina Santos, Andrea Ruiz, Orla Casey, Verena Murphy, Matthias Ebert, Livio Trusolino, Diether Lambrechts, Anguraj Sadanandam, Catherine Sautès‐Fridman, Jochen Prehn, Paolo Nuciforo, Jacques Fieschi, Florence Monville, Darran O'Connor, Wolf Fridman, Annette Byrne   +61 more
wiley   +1 more source

Rethinking plastic waste: innovations in enzymatic breakdown of oil‐based polyesters and bioplastics

FEBS Open Bio, EarlyView.
Plastic pollution remains a critical environmental challenge, and current mechanical and chemical recycling methods are insufficient to achieve a fully circular economy. This review highlights recent breakthroughs in the enzymatic depolymerization of both oil‐derived polyesters and bioplastics, including high‐throughput protein engineering, de novo ...
Elena Rosini, Nicolò Antonelli, Gianluca Molla   +2 more
wiley   +1 more source

Nuclear energy density functional from chiral pion-nucleon dynamics: Isovector terms

, 2010
We extend a recent calculation of the nuclear energy density functional in the framework of chiral perturbation theory by computing the isovector surface and spin-orbit terms: $(\vec \nabla \rho_p- \vec \nabla \rho_n)^2 G_d(\rho)+ (\vec \nabla \rho_p ...
B.D. Serot, E. Chabanat, E. Chabanat, J. Bartel, J. Dobaczewski, J. Fujita, J.E. Drut, J.R. Stone, J.W. Negele, M. Beiner, M. Bender, M. Samyn, N. Chamel, N. Kaiser, N. Kaiser, N. Kaiser, N. Kaiser, N. Kaiser, N. Kaiser, N. Kaiser, O. Plohl, P. Finelli, P.G. Reinhart, R. Roth, S. Fritsch, S. Goriely, S.K. Bogner, S.K. Bogner, T. Lesinski   +28 more
core   +1 more source

Maintaining coherence in Quantum Computers [PDF]

, 1994
The effect of the inevitable coupling to external degrees of freedom of a quantum computer are examined. It is found that for quantum calculations (in which the maintenance of coherence over a large number of states is important), not only must the ...
A. Leggett, A.O. Caldera, C.P. Slichter, D. Deutsch, W. G. Unruh, W. Unruh   +5 more
core   +5 more sources

Pathogenic Neurofibromatosis type 1 gene variants in tumors of non‐NF1 patients and role of R1276

FEBS Open Bio, EarlyView.
Somatic variants of the neurofibromatosis type 1 (NF1) gene occur across neoplasms without clinical manifestation of the disease NF1. We identified emerging somatic pathogenic NF1 variants and hotspots, for example, at the arginine finger 1276. Those missense variants provide fundamental information about neurofibromin's role in cancer.
Mareike Selig, Swanhild Lohse, Sara Elahi, Nils Hartmann, Stefanie Deckert, Shutian Si, Alexander Desuki, Anja Harder   +7 more
wiley   +1 more source