Results 91 to 100 of about 230,180 (265)

Down‐regulation of Shh in the hair follicles of mice during chemotherapy‐induced hair loss is mediated by the JAK/STAT1 signaling pathway

FEBS Open Bio, EarlyView.
We found that during chemotherapy‐induced alopecia (CIA), Sonic hedgehog (Shh) expression significantly decreased in hair follicle Shh+ cells, whereas the Janus‐activated kinase/signal transducer and activator of transcription 1 (JAK/STAT1) signaling pathway was markedly activated.
Ruifang Fan, Jingling Huang, Xiang Lin, Tingjiao Lan, Yuli Tang, Ling Sun, Guixuan Zhou   +6 more
wiley   +1 more source

Strength of artificially frozen sand with low confining pressure under a three-dimensional stress path

Scientific Reports
True triaxial tests were conducted on artificially frozen sand. The effects of the intermediate principal stress coefficient, temperature and confining pressure on the strength of frozen sand were studied. The stress–strain curves under different initial
Zhaoming Yao, Xinjie Xu, Shuang Liu
doaj   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

A New Shear Strength Criterion for Rock Masses with Non-Persistent Discontinuities Considering the Nonlinear Progressive Failure Process. [PDF]

Materials (Basel), 2020
Zheng B, Qi S, Guo S, Huang X, Liang N, Zou Y, Luo G.   +6 more
europepmc   +1 more source

STRENGTH CRITERION OF ROCKS

STRENGTH CRITERION OF ROCKS
rights: 社団法人地盤工学会rights: 本文データは学協会の許諾に基づきCiNiiから複製したものであるrelation: IsVersionOf: http://ci.nii.ac.jp/naid/110003959317/
openaire  

Engineering tandem VHHs to target different epitopes to enhance antibody‐dependent cell‐mediated cytotoxicity

FEBS Open Bio, EarlyView.
Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu, Hao Jiang, Limin Chen, Fulai Zhou, Ying Jin, Mark L. Chiu   +5 more
wiley   +1 more source

Grip Strength Criterion Matters: Impact of Average Versus Maximum Handgrip Strength on Sarcopenia Prevalence and Predictive Validity for Low Physical Performance. [PDF]

J Nutr Health Aging, 2020
Lim JP, Yew S, Tay L, Chew J, Yeo A, Hafizah Ismail N, Ding YY, Lim WS.   +7 more
europepmc   +1 more source

Enzymatic degradation of biopolymers in amorphous and molten states: mechanisms and applications

FEBS Open Bio, EarlyView.
This review explains how polymer morphology and thermal state shape enzymatic degradation pathways, comparing amorphous and molten biopolymer structures. By integrating structure–reactivity principles with insights from thermodynamics and enzyme engineering, it highlights mechanisms that enable efficient polymer breakdown.
Anđela Pustak, Aleksandra Maršavelski
wiley   +1 more source

Strength criterion and verification of transversely isotropic unsaturated loess based on spatial sliding surface variation

Yantu gongcheng xuebao
In order to scientifically predict the strength and deformation characteristics of large-area fill foundations, a comprehensive and systematic study is conducted on mechanical properties of transversely isotropic unsaturated remolded loess through ...
GUO Nan1 , YANG Xiaohui1, JIA Shining1, CHEN Zhenghan1, 2
doaj   +1 more source