Results 71 to 80 of about 230,180 (265)

Screening for lung cancer: A systematic review of overdiagnosis and its implications

Molecular Oncology, EarlyView.
Low‐dose computed tomography (CT) screening for lung cancer may increase overdiagnosis compared to no screening, though the risk is likely low versus chest X‐ray. Our review of 8 trials (84 660 participants) shows added costs. Further research with strict adherence to modern nodule management strategies may help determine the extent to which ...
Fiorella Karina Fernández‐Sáenz, Laura de la Torre‐Perez, David R Baldwin, Carlijn van der Aalst, Mangesh Thorat, David Ritchie, Andre L Carvalho, Carolina Espina, Ivan Solà, Carlos Canelo‐Aybar, Moira Magdalena Pissinis, Pablo Alonso‐Coello, Ana Carolina Pereira Nunes Pinto   +12 more
wiley   +1 more source

Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA

Molecular Oncology, EarlyView.
Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson, Anders Lade Nielsen, Boe Sandahl Sorensen   +2 more
wiley   +1 more source

Delamination during buckling of composite constructional elements

Aviation, 2010
Laminated constructional elements have widespread applications in aerospace. This paper presents of the buckling for E‐Glass. Design solution based by the criteria of strength materials. The delamination of composite constructional elements is determined
Antanas Žiliukas
doaj   +1 more source

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

Molecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia, Noelia Moares, Wenjie Yi‐He, Rosa Luna‐Espejo, Ricardo Fernandez‐Cisnal, Javier Ocaña‐Cuesta, Juan P. Muñoz‐Miranda, Antonio Gabucio, Cecilia M. Fernandez‐Ponce, Francisco Garcia‐Cozar   +9 more
wiley   +1 more source

Comparison and analysis for prediction accuracy of true triaxial rock strength criterion

Frontiers in Earth Science
To verify the predictive accuracy of existing strength criteria on true triaxial strength experimental data, understand the characteristics of different strength criteria, and provide a basis for selecting strength criteria for engineering applications ...
Shiwei He, Hong Cheng, Lin Cheng, Feiyu Yuan, Mingming Zhang   +4 more
doaj   +1 more source

Strength through diversity: how cancers thrive when clones cooperate

Molecular Oncology, EarlyView.
Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken, Maartje Witsen, Emile E. Voest, Krijn K. Dijkstra   +3 more
wiley   +1 more source

Chemical Corrosion-Water-Confining Pressure Coupling Damage Constitutive Model of Rock Based on the SMP Strength Criterion. [PDF]

Materials (Basel), 2023
Chen Y, Tong H, Chen Q, Du X, Wang S, Pan Y, Dong Y, Ma H.   +7 more
europepmc   +1 more source

Next‐generation proteomics improves lung cancer risk prediction

Molecular Oncology, EarlyView.
This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj, Clara Frick, Ben Schöttker, Bernd Holleczek, Hermann Brenner   +4 more
wiley   +1 more source

EMPIRICAL STRENGTH CRITERION OF COMPOSITE MATERIALS

Вестник Донского государственного технического университета, 2018
Empirical long-term strength criterion in terms of limit stress for constructive polymer materials considering ageing factor is found. The criterion corresponds to the type of Goldenblat - Kopnov.
O.G. OSYAEV
doaj  

Innovative Data-Driven Machine Learning Approaches for Predicting Sandstone True Triaxial Strength

Applied Sciences
Given the critical role of true triaxial strength assessment in underground rock and soil engineering design and construction, this study explores sandstone true triaxial strength using data-driven machine learning approaches. Fourteen distinct sandstone
Rui Zhang, Jian Zhou, Zhenyu Wang
doaj   +1 more source