Results 41 to 50 of about 2,100,921 (289)
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Discover Public HealthIntroduction Over the past two decades, Sub-Saharan Africa has achieved remarkable progress toward the UNAIDS 95-95-95 targets through sustained donor investment, community leadership, and political commitment.
David Olpengs, Jennifer Mamwa
doaj +1 more source
Estimating non-communicable disease treatment costs using probability-based cost estimation
Global Health Action, 2022 The burden and impact of non-communicable diseases (NCDs) are well documented, accounting for 70% of premature deaths globally. In Sub-Saharan Africa, rising NCDs are estimated to account for 27% of mortality by 2020, a 4% increase from 2005.
Claire R. Botha, Sten H. Vermund
doaj +1 more source
International Journal of High Technology Ceramics, 1986 Relatively large Al2O3 disc particles (16μm, 41μm) with high aspect ratios (5-20) were incorporated into a fine-grain Al2O3 matrix (-1μm) in order to improve the mechanical properties of sintered Al2O3. The flexural strength depends on the disc size and the microstructure of composites.
Tetsuo UCHIYAMA +2 more
openaire +2 more sources
Strengthening Neighbourhood Substitution [PDF]
, 2020 Domain reduction is an essential tool for solving the constraint satisfaction problem (CSP). In the binary CSP, neighbourhood substitution consists in eliminating a value if there exists another value which can be substituted for it in each constraint.
openaire +2 more sources
Molecular Oncology, EarlyView.ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang +8 more
wiley +1 more source
Canadian Family Physician, 2021 ![Figure][1] When family medicine is strong and effective, so is the health care system. Our Outcomes of Training project will take us further on the journey of strengthening our discipline. After moving beyond the GP of the mid-20th century—an individual doctor providing all care for “
openaire +2 more sources
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
InventionsTo mitigate the inherent high flow resistance of conventional corrugated tubes, a novel design with alternating clockwise/counterclockwise corrugated segments separated by smooth sections is proposed.
Junwen Cheng +6 more
doaj +1 more source
International Journal of Concrete Structures and Materials, 2018 This paper aims to investigate the behavior of fiber reinforced polymer (FRP) strengthened reinforced concrete (RC) beams containing large rectangular web openings in the flexure zone.
Tarek Almusallam +4 more
doaj +1 more source