Results 51 to 60 of about 860,869 (316)

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

Role of recycled vehicle tires quantity and size on the properties of metakaolin-based geopolymer rubberized concrete

Journal of Materials Research and Technology, 2022
Increasing demand for concrete construction and the consequent increase in the production of conventional Portland cement is thwarting efforts towards sustainable construction practices.
Abdulrahman Albidah, Abdulaziz Alsaif, Aref Abadel, Husain Abbas, Yousef Al-Salloum   +4 more
doaj   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Heat Transfer Enhancement and Flow Resistance Characteristics in a Tube with Alternating Corrugated-Smooth Segments

Inventions
To mitigate the inherent high flow resistance of conventional corrugated tubes, a novel design with alternating clockwise/counterclockwise corrugated segments separated by smooth sections is proposed.
Junwen Cheng, Jiahao Zhu, Xin Wen, Haodong Yu, Wei Lin, Zuqiang Xin, Jiuyang Yu   +6 more
doaj   +1 more source

Strengthening rules-based order in the Asia-Pacific [PDF]

, 2014
This paper explores the opportunities for both Australia and Japan jointly to promote their shared interest in strengthening the rule of law in the Asia–Pacific.
Anthony Bergin, David Lang
core  

Architectural Expression of Seismic Strengthening [PDF]

, 2001
Current seismic strengthening approaches to historic buildings place emphasis upon concealing engineering technologies. This study investigates, through a process of architectural and structural engineering design, the architectural possibilities ...
Preston, Julieanna, Taylor, Mark, Charleson, Andrew   +2 more
core   +1 more source

Muscle-strengthening exercise epidemiology : a new frontier in chronic disease prevention [PDF]

, 2020
This current opinion provides an overview of the emerging discipline of muscle-strengthening exercise epidemiology. First, we define muscle-strengthening exercise, and discuss its recent addition into the global physical activity guidelines, which were ...
De Cocker, Katrien, Shakespear-Druery, Jane, Bennie, Jason A.   +2 more
core   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Behavior of FRP-Strengthened RC Beams with Large Rectangular Web Openings in Flexure Zones: Experimental and Numerical Study

International Journal of Concrete Structures and Materials, 2018
This paper aims to investigate the behavior of fiber reinforced polymer (FRP) strengthened reinforced concrete (RC) beams containing large rectangular web openings in the flexure zone.
Tarek Almusallam, Yousef Al-Salloum, Hussein Elsanadedy, Abdulhafiz Alshenawy, Rizwan Iqbal   +4 more
doaj   +1 more source