Results 71 to 80 of about 860,869 (316)

Improved detection of microbiological pathogens: role of partner and non-governmental organizations

BMC Infectious Diseases, 2021
Background Proper detection of disease-causing organisms is very critical in controlling the course of outbreaks and avoiding large-scale epidemics. Nonetheless, availability of resources to address these gaps have been difficult due to limited funding ...
Michael Owusu, Bernard Nkrumah, Godfred Acheampong, Ebenezer Kofi Mensah, Abass Abdul-Karim Komei, Festus Kofi Sroda, Sambian David, Shannon Emery, Lucy Maryogo Robinson, Kwame Asante, David Opare   +10 more
doaj   +1 more source

Seismic strengthening of rigid steel frame with CFRP [PDF]

, 2019
Steel frames are a very popular choice in building construction and are used extensively in high seismic risk regions across the world. These existing and future constructed steel frames may need to undergo seismic strengthening to mitigate the high ...
Tafsirojjaman, T., Zhao, X. L., Fawzia, S., Thambiratnam, D.   +3 more
core   +1 more source

Weakening the nuclear envelope: Lamin B receptor in melanoma metastasis

Molecular Oncology, EarlyView.
LBR‐driven nuclear fragility supports melanoma invasion. A: Melanocyte presents low LBR (Lamin B Receptor) levels, maintaining nuclear integrity and lamina‐chromatin tethering. B: During malignant progression, upregulation of LBR clusters at the INM (Inner Nuclear Membrane) during confined migration causes local lamina weakening and cholesterol ...
Francesca Lorenzini, Maria Caterina Mione   +1 more
wiley   +1 more source

Antimicrobial resistance databases: opportunities and challenges for public health

npj Antimicrobials and Resistance
Antimicrobial resistance (AMR) databases enable the identification of AMR determinants from pathogen sequence data and the prediction of resistance profiles, enhancing AMR surveillance and informing a range of public health interventions.
Chad M. Centner, Sabrina Di Gregorio, Silvia Argimón, Alice Brankin, Anna Dean, Daniel Marcano Zamora, Silvia Bertagnolio   +6 more
doaj   +1 more source

Early implementation of guidelines for managing young infants with possible serious bacterial infection in Bangladesh

BMJ Global Health, 2019
Neonatal infections remain a leading cause of newborn deaths globally. In 2015, WHO issued guidelines for managing possible serious bacterial infection (PSBI) in young infants (0–59 days) with simpler antibiotic regimens if hospital referral is not ...
Abdullah H Baqui, Marufa Aziz Khan, Nazmul Kabir, Joby George, Iftekhar Rashid, Jennifer A Applegate, Sabbir Ahmed, Sanjida Alam, Munia Islam, Mamun Bhuiyan, Jahurul Islam, Steve Wall, Joseph de Graft-Johnson   +12 more
doaj   +1 more source

Community Strengthening Evidence Review

, 2023
With a growing body of research supporting the effectiveness of community-led and engagement initiatives, this review takes a closer look at what makes these approaches successful.
Parker, Rhiannon ; https://orcid.org/, Varadharajan, Meera ; https://orcid.org/, Yao, Yi Sing, Noone, Jack ; https://orcid.org/   +3 more
core   +1 more source

Matrix metalloproteinase‐9 regulates cell adhesion and membrane protrusive activity of ovarian cancer cells

FEBS Open Bio, EarlyView.
Matrix metalloproteinase‐9 (MMP9) drives ovarian cancer progression. Using MMP9‐null cells (M9‐KO) created from ovarian cancer cells, we found MMP9 loss did not block Epidermal Growth Factor (EGF)‐driven E‐cadherin dissolution or EMT but delayed and reduced EGF‐driven membrane protrusions. Transient MMP9 re‐expression drove membrane protrusion.
Claire Strauel, Sam Bennett, Natalie Ehlinger, Nelson Cook, Katelyn Marvin, Caleb L. Lines, Sam Reyes, Brooke Kirby, Shawn M. Ellerbroek   +8 more
wiley   +1 more source

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

FEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke, Michal Banasik, Rokas Juodeikis, Martin J. Warren, Richard W. Pickersgill   +4 more
wiley   +1 more source

Strengthening the remaining synapses [PDF]

Science, 2017
Neuroscience Working memory depends in part on the proper activation of neural circuits in a brain area called the dorsolateral prefrontal cortex (DLPFC). In primates, DLPFC performance during working memory tasks improves through adolescence. Synaptic pruning eliminates unwanted or imprecise connections and strengthens the remaining connections. Chung
openaire   +2 more sources

Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum

FEBS Open Bio, EarlyView.
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik, Russell Pickford, Hannah C. Timmins, Olivier Piguet, Glenda M. Halliday, Matthew C. Kiernan, Woojin Scott Kim   +6 more
wiley   +1 more source