Results 61 to 70 of about 2,100,921 (289)
Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers
Molecular Oncology, EarlyView.This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel +6 more
wiley +1 more source
Antimicrobial resistance databases: opportunities and challenges for public health
npj Antimicrobials and ResistanceAntimicrobial resistance (AMR) databases enable the identification of AMR determinants from pathogen sequence data and the prediction of resistance profiles, enhancing AMR surveillance and informing a range of public health interventions.
Chad M. Centner +6 more
doaj +1 more source
A landscape analysis of clinical trials and infant clinical trials in Kenya, Ethiopia, and Nigeria
Frontiers in EpidemiologyIntroductionGlobal inequality in clinical research capacity and service delivery can be indicated simply by the proportion of clinical trials that a country or region has registered in clinical trial registry databases.
Patrick Amboka +5 more
doaj +1 more source
Improved detection of microbiological pathogens: role of partner and non-governmental organizations
BMC Infectious Diseases, 2021 Background Proper detection of disease-causing organisms is very critical in controlling the course of outbreaks and avoiding large-scale epidemics. Nonetheless, availability of resources to address these gaps have been difficult due to limited funding ...
Michael Owusu +10 more
doaj +1 more source
Strengthening Community Colleges' Influence on Economic Mobility [PDF]
, 2009 Examines the role of community colleges in enhancing upward mobility. Compares family incomes of community college and four-year college students and incomes by degree attained.
Christine G. Mokher +2 more
core
On the velocity-strengthening behavior of dry friction
, 2014 The onset of frictional instabilities, e.g. earthquakes nucleation, is intimately related to velocity-weakening friction, in which the frictional resistance of interfaces decreases with increasing slip velocity.
Bar-Sinai, Yohai +3 more
core +1 more source
RIPK4 function interferes with melanoma cell adhesion and metastasis
Molecular Oncology, EarlyView.RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski +9 more
wiley +1 more source
BMJ Global Health, 2019 Neonatal infections remain a leading cause of newborn deaths globally. In 2015, WHO issued guidelines for managing possible serious bacterial infection (PSBI) in young infants (0–59 days) with simpler antibiotic regimens if hospital referral is not ...
Abdullah H Baqui +12 more
doaj +1 more source
COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells
Molecular Oncology, EarlyView.This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos +6 more
wiley +1 more source
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source