Results 151 to 160 of about 236,402 (293)

Affinity-Activated Protein Switches for Modular and Signal-ON Detection of Small Molecules. [PDF]

Anal Chem
Wu CC, Chen HM, Chang TJ, Weng LL, Wang YC, Chao KC, Lin JC, Jian BL, Chu LA, Tan KT.   +9 more
europepmc   +1 more source

MOSFET-type biosensor for detection of streptavidin-biotin protein complexes

, 2019
A p-channel metal oxide semiconductor field-effect transistor (PMOSFET)-type biosensor for detecting streptavidin-biotin protein complexes has been fabricated.
Park, JE, Kim, DS, Shin, JK, Lim, G, Park, HJ, Seo, HI, Kang, SW   +6 more
core  

Tumor‐Derived Exosomal circAP2B1 Induces M2 Macrophage Polarization by Enhancing Mitochondrial Homeostasis to Promote Esophageal Squamous Cell Carcinoma Progression

Advanced Science, EarlyView.
ESCC‐derived exosomal circAP2B1 promotes tumor progression by reprogramming mitochondrial metabolism via the ESRRA/KPNA1/MFN2 axis to induce M2 polarization of macrophages. ABSTRACT Esophageal squamous cell carcinoma (ESCC) remodels the immunosuppressive tumor microenvironment via exosome‐mediated intercellular communication.
Yiru Wang, Gang Feng, Youyu Wang, Ruihao Liang, Haixia Pan, Kai Lei   +5 more
wiley   +1 more source

ChromID: A Protocol for Mapping Protein Chromatin Interactions in Living Cells. [PDF]

Bio Protoc
Cardoso da Silva R, Ten Bulte D, Baubec T.   +2 more
europepmc   +1 more source

Systematic Multi‐Level Analyses Decode the Arthritis‐Neurodegeneration Axis With In Vivo Validation

Advanced Science, EarlyView.
Arthritis and neurodegeneration are usually studied as separate disorders, but this study connects them through population evidence, genetic inference, transcriptomic mapping, and mouse models. It highlights RNF40 as a context‐dependent joint‐brain candidate, induced in inflammatory joints yet functionally linked to dopamine‐neuron vulnerability ...
Jinwen Wang, Wenhui Xie, Lei Yang, Zhengrong Wang, Yi Huang, Peng Huang, Yuan Liu, Jun Hu   +7 more
wiley   +1 more source

Protocol for conditional mapping of proximal interactomes of dimeric protein complexes using a BioID-based complementation approach. [PDF]

STAR Protoc
Rajkumar A, Gaudreau-Lapierre A, Anthony CLF, Trinkle-Mulcahy L.   +3 more
europepmc   +1 more source

Rhoifolin Alleviates Ulcerative Colitis by Targeting NMNAT1 and Activating SIRT1‐FOXO1 Signaling to Enhance ILC3s Effector Function

Advanced Science, EarlyView.
Rhoifolin directly targets NMNAT1, thereby activating nicotinamide salvage pathway and promoting intracellular NAD+ biosynthesis. Elevated NAD+ levels enhance SIRT1 activity, leading to FOXO1 deacetylation and nuclear translocation. Nuclear FOXO1 subsequently binds to the IL‐22 promoter, upregulating IL‐22 transcription and potentiating ILC3 effector ...
Hongqiong Yang, Yishu Zhang, Sijia Feng, Xiaoqing Ma, Jiayi Feng, Junwei Wang, Jialin Gao, An Pan, Dapeng Wu, Kang Ding, Caijuan Zheng, Qi Lv, Lihong Hu   +12 more
wiley   +1 more source

Discovery of low molecular weight protein-binding fragments from bead-displayed libraries: application to monomeric proteins. [PDF]

RSC Chem Biol
Tong J, Jayalath IM, Parsons JV, Kim JA, Mann MD, Tokmina-Roszyk M, Kodadek T.   +6 more
europepmc   +1 more source

Streptavidin surprises [PDF]

Nature Methods, 2005
openaire   +1 more source

Long Noncoding RNA PCALRx Interacts with Pyruvate Carboxylase to Drive Multi‐Organ Developmental Toxicity in Zebrafish Embryos Exposed to Amoxicillin

Advanced Science, EarlyView.
Embryonic amoxicillin exposure disrupts multi‐organ development in zebrafish larvae through a lncRNA–metabolic enzyme regulatory axis. PCALRx associates with pyruvate carboxylase, promotes PC protein ubiquitination, and impairs mitochondrial energy metabolism, while vitamin B1 partially restores PC‐centered metabolic function and developmental outcomes.
Yixue Yao, Ping Jiang, Xinli Zhou, Mengying Yin, Qiong Luo, Hui Wang   +5 more
wiley   +1 more source