Results 271 to 280 of about 323,420 (331)

Development of potent Affitin-based bispecific NK cell engagers for the therapy of MSLN-expressing cancers. [PDF]

Mol Ther Oncol
Briolay T, Petithomme T, Gravoueille H, Fresquet J, Lambot S, Cossard P, Mouratou B, Fortun A, Bernardeau K, Quéméner A, Maillasson M, Boisgerault N, Mortier E, Davodeau F, Pecorari F, Blanquart C.   +15 more
europepmc   +1 more source

High-yield production of Streptavidin with native C-terminal in Escherichia coli

, 2011
Xuelan Chen
openalex   +1 more source

GOT1 Inhibition Induces Extracellular Matrix Remodeling in Pancreatic Cancer

Advanced Science, EarlyView.
Using tumor tissue engineering, we recreated pancreatic cancer and found that inhibiting glutamic‐oxaloacetic transaminase 1 (GOT1) induces extracellular matrix remodeling and secretome rewiring, as well as promotes cell death. ABSTRACT Pancreatic cancer cells rely on glutamine to sustain their survival in the stiff and poorly vascularized tumor ...
Rodrigo Curvello, Sandra Hauser, Michael Seifert, Christopher K. Barlow, Joel R. Steele, Emma Salisbury, Daniel Croagh, Kathryn S. Stok, Anna V. Taubenberger, Ralf B. Schittenhelm, Daniela Loessner   +10 more
wiley   +1 more source

A LisH-domain protein interaction map reveals a Lis1-ARIH2-dynein regulatory axis. [PDF]

iScience
Gupta D, Maddika S.
europepmc   +1 more source

eLife Assessment: Beyond BioID: Streptavidin outcompetes antibody fluorescence signals in protein localization and readily visualises targets evading immunofluorescence detection

Timothy J. Stasevich
openalex   +1 more source

Targeting IL27RA Enhances Immunotherapy in Triple‐Negative Breast Cancer by Modulating Tumor Cells and the Tumor Microenvironment

Advanced Science, EarlyView.
IL27RA upregulation drives immune evasion in TNBC by suppressing MHC‐I expression and reprogramming T/NK‐cell states, establishing an immune‐excluded tumor phenotype. Targeting this epithelial‐intrinsic IL27RA–PI3K/AKT axis offers a promising strategy to overcome immunotherapy resistance.
Jiachi Xu, Qian Long, Meirong Zhou, Qitong Chen, Jing Peng, Qingchun Liang, Danhua Zhang, Hui Zhou, Wenjun Yi   +8 more
wiley   +1 more source

Spatial Molecular Heterogeneity on Biofunctionalized Particles Quantified by Three-Dimensional Single-Molecule DNA-PAINT. [PDF]

Langmuir
Tan WS, de Jong AM, Prins MWJ.
europepmc   +1 more source

DNA‐Guided Robust Single‐Protein Electronic Readout

Advanced Science, EarlyView.
Electronic measurements of single proteins can reveal fundamental insights into their structure, dynamics, and interactions, but reproducibility is severely limited by the intrinsic structural heterogeneity of proteins combined with uncontrolled molecular orientation and electrode contact geometries.
Ziyi Ju, Zhaoxiang Deng, Yueqi Li, Jinghong Li   +3 more
wiley   +1 more source

Targeting Siglec-sialic acid checkpoint to reverse immune dysfunction mediated by plasmacytoid dendritic cells in myeloma. [PDF]

Blood Adv
Ray A, Buon L, Wan X, Du T, Song Y, Pillai SC, Musa MA, Fang T, Wang M, Anderson KC.   +9 more
europepmc   +1 more source

DR5 Governs Compound Exocytosis in Colonic Goblet Cells via TATA‐Box Binding Protein‐Dependent Bestrophin‐2 Transcriptional Regulation

Advanced Science, EarlyView.
DR5 knockout exhibits a thinner colonic mucus layer, leading to mild dysbiosis, increased susceptibility to Citrobacter rodentium invasion, and exacerbated epithelial injury. Mechanistically, DR5 binds transcription factor TBP, which regulates the expression of gene Best2 via its promoter.
Ying Wang, Xinyun Li, Yong Wang, Chuhe Yang, Xiaopei Gao, Ke Zhu, Yihang Ren, Jingxin Li, Chuanyong Liu, Bing Xue   +9 more
wiley   +1 more source