Results 311 to 320 of about 326,708 (370)

Urapidil as a neuroprotective agent: targeting hypoxia, inflammation, and oxidative stress in traumatic brain injury. [PDF]

Eur J Trauma Emerg Surg
Bindal A, Karabacak P, Asci H, Ilhan I, Tepebasi MY, Sevuk MA, Imeci O, Ozmen O, Yildirim B.   +8 more
europepmc   +1 more source

Simvastatin overcomes the pPCK1‐pLDHA‐SPRINGlac axis‐mediated ferroptosis and chemo‐immunotherapy resistance in AKT‐hyperactivated intrahepatic cholangiocarcinoma

Cancer Communications, EarlyView.
Abstract Background Intrahepatic cholangiocarcinoma (ICC) is a challenging cancer with an increasing incidence. The Phase III TOPAZ‐1/KEYNOTE‐966 study demonstrated chemo‐immunotherapy (CIT) as a significant advancement, potentially replacing traditional chemotherapy for advanced biliary tract cancer.
Jinghan Zhu, Yixiao Xiong, Yuxin Zhang, Huifang Liang, Kun Cheng, Yuanxiang Lu, Guangzhen Cai, Yang Wu, Yunhui Fan, Xiaoping Chen, Hong Zhu, Zeyang Ding, Wanguang Zhang   +12 more
wiley   +1 more source

A dual-purification system to isolate mitochondrial subpopulations.

J Cell Sci
Cunningham CN, Van Vranken JG, Larios J, Heyden K, Gygi SP, Rutter J.   +5 more
europepmc   +1 more source

Crystal structure of Isthmin-1 and reassessment of its functional role in pre-adipocyte signaling. [PDF]

Nat Commun
Li T, Stayrook SE, Li W, Wang Y, Li H, Zhang J, Liu Y, Klein DE.   +7 more
europepmc   +1 more source

Targeting MAN1B1 potently enhances bladder cancer antitumor immunity via deglycosylation of CD47

Cancer Communications, EarlyView.
Abstract Background Only a few bladder cancer patients benefit from anti‐programmed cell death protein 1/programmed cell death ligand 1 immunotherapy. The cluster of differentiation 47 (CD47) plays an important role in tumor immune evasion. CD47 is a highly glycosylated protein, however, the mechanisms governing CD47 glycosylation and its potential ...
Jie Zhang, Chen Zhang, Ruichen Zang, Weiwu Chen, Yining Guo, Haofei Jiang, Jing Le, Kunyu Wang, Haobo Fan, Xudong Wang, Sisi Mo, Peng Gao, Wenhao Guo, Xinrong Jiang, Fengbin Gao, Junming Jiang, Juyan Zheng, Yuxing Chen, Yicheng Chen, Yanlan Yu, Guoqing Ding   +20 more
wiley   +1 more source

Silica-coated magnetic nanobeads in a flow enrichment target capture Halbach (FETCH) magnetic separation system for circulating tumor cell enrichment. [PDF]

FEBS Lett
Liu P, He S, Mentink A, Hart P, Wu Y, Terstappen LWMM, Jonkheijm P, Stevens M.   +7 more
europepmc   +1 more source

Photoactivatable Alkyne Tag for Photolabeling Biomolecules in Living Cells

ChemBioChem, EarlyView.
A photoactivatable linear alkyne tag is developed by caging the intermediate of the Eschenmoser–Tanabe reaction to expand photoinduced intracellular molecular imaging to a variety of biomolecules. The photoactivatable tag is modified onto a cholesterol analog and introduced into cells. After light irradiation, the tag is successfully labeled with azide‐
Yuki Umeda, Hao Zhu, Satoshi Yamaguchi, Sho Nakamura, Masato Takada, Shin Izuta, Akimitsu Okamoto   +6 more
wiley   +1 more source

Advances in Surrogate Neutralization Tests for High-Throughput Screening and the Point-of-Care. [PDF]

Anal Chem
Streif S, Baeumner AJ.
europepmc   +1 more source

Exploiting SpyTag/SpyCatcher Technology to Design New Artificial Catalytic Copper Proteins

ChemBioChem, EarlyView.
Designing artificial metal sites in proteins is challenging due to the need to place the metal site in precise positions and to tailor the coordination environment of the metal. A modular approach based on the SpyTag/SpyCatcher technology is used to provide the Spy construct with a Cu2+/ATCUN site.
Silvia Gentili, Francesca Miglioli, Valentina Borghesani, Gloria Spagnoli, Denise Bellotti, Davide Cavazzini, Remo Guerrini, Maurizio Remelli, Giovanni Maestri, Simone Ottonello, Angelo Bolchi, Matteo Tegoni   +11 more
wiley   +1 more source

Integrated Device for Cancer Nucleic Acid Biomarker Detection at Body Temperature. [PDF]

Micromachines (Basel)
Chen C, Wu B, Li X, Jin Y, Zhang H, Liu B, Zhang Z, Li N.   +7 more
europepmc   +1 more source