Results 101 to 110 of about 219,558 (346)

ThiF‐Like Enzyme Chemistry in Primary and Secondary Metabolism

ChemBioChem, EarlyView.
ThiF‐like enzymes are a widespread protein family found in disparate biosynthetic pathways. They are unified by their use of an NTP to modify a carboxylate, generating an activated species prone to nucleophilic addition. This common intermediate is then targeted by diverse nucleophiles, including persulfide or amino acid side chains, to yield a variety
Keelie S. Butler, Anshul Rajput, Jonathan R. Chekan   +2 more
wiley   +1 more source

Hierarchical clustering of clinical and flow cytometry parameters is associated with deterioration in patients with community‐acquired pneumonia in the emergency department: A preliminary study

Cytometry Part B: Clinical Cytometry, EarlyView.
ABSTRACT Anticipating the evolution of septic patients with community‐acquired pneumonia (CAP) is challenging for front‐line physicians in the Emergency Department (ED). Prognosis depends mainly on early identification, antibiotics, organ support, but also immune status.
Thomas Lafon, Robin Jeannet, Thomas Daix, Guillaume Monneret, Jean Feuillard   +4 more
wiley   +1 more source

Amidine Syntheses from Classic to Contemporary for Medicinal Lead Compounds and Natural Products

European Journal of Organic Chemistry, EarlyView.
A revolution is underway in the synthesis of amidines with new methods unlocking complex, highly substituted amidines or closely related derivatives such as N‐sulfonyl amidines. This review surveys recent advances in amidines and related compounds, including methods to install them and bioactive molecules prominently featuring the amidine functionality.
Wyatt R. Swift‐Ramirez, Gregory A. Weiss   +1 more
wiley   +1 more source

The role of the host—Neutrophil biology

Periodontology 2000, EarlyView., 2023
Abstract Neutrophilic polymorphonuclear leukocytes (neutrophils) are myeloid cells packed with lysosomal granules (hence also called granulocytes) that contain a formidable antimicrobial arsenal. They are terminally differentiated cells that play a critical role in acute and chronic inflammation, as well as in the resolution of inflammation and wound ...
Iain L. C. Chapple, Josefine Hirschfeld, Alpdogan Kantarci, Asaf Wilensky, Lior Shapira   +4 more
wiley   +1 more source

Development of a Promising Bivalent Vaccine Against Klebsiella pneumoniae Based on Glycoengineered GMMA (geGMMA)

Exploration, EarlyView.
Multidrug‐resistant Klebsiella pneumoniae poses a significant threat as a nosocomial pathogen, with no current licensed vaccines available. This study used a mutant E. coli strain expressing exogenous polysaccharides (from K. pneumoniae) to establish glycoengineered generalized modules for membrane antigens (geGMMA) vaccine platform, which demonstrated
Jingqin Ye, Wenhua Huang, Shujuan Yu, Yan Guo, Peng Sun, Ziyuan Chen, Linhui Hao, Yan Zhang, Caixia Li, Yongqiang Jiang, Jun Wu, Li Zhu, Hengliang Wang, Chao Pan   +13 more
wiley   +1 more source

Diagnosis of Streptococcus Pneumoniae based on cpsB, cpsD, and psaA Genes

Journal of Mazandaran University of Medical Sciences, 2018
Background and purpose: Fast diagnosis of pneumococcal infections is of great importance in achieving successful outcomes. The aim of this study was to use PCR process based on capsular encoding genes of Streptococcus pneumonia. Materials and methods: In
Ali Asgari, Ramezan Ali Ataee, Mahdi Ghorbanalizadegan, Ali Mehrabi Tavana   +3 more
doaj  

Phage inducible islands in the gram-positive cocci [PDF]

, 2016
The SaPIs are a cohesive subfamily of extremely common phage-inducible chromosomal islands (PICIs) that reside quiescently at specific att sites in the staphylococcal chromosome and are induced by helper phages to excise and replicate.
A Bolotin, A Chopin, A Ruzin, B Frígols, BA Duerkop, C Ubeda, C Ubeda, C Ubeda, C Ubeda, C Ubeda, CH O'Callaghan, CM Hamilton, D Straume, D Viana, Davida Smyth, E Charpentier, E Maiques, G Ram, G Ram, Geeta Ram, IT Paulsen, J Chen, J Chen, J Chen, J Scott, J Scott, J-P Claverys, JA Lindsay, John Chen, José R Penadés, JR Penadés, M Kanehisa, MA Tormo, MD Ferrer, Miguel Martí, MÁ Tormo-Más, MÁ Tormo-Más, N Carpena, N Quiles-Puchalt, N Quiles-Puchalt, Nuria Quiles-Puchalt, RC Matos, Richard P Novick, Roser Martínez-Rubio, RP Novick, RP Novick, Suzanne Humphrey, SV Nguyen   +47 more
core   +1 more source

Anti‐Inflammatory Effects of Flavonoids in Otitis Media: A Systematic Review of Pre‐Clinical Evidence

Food Frontiers, EarlyView.
Otitis media (OM) is a middle ear infection driven by chronic inflammation, leading to tissue damage and complications such as cholesteatoma. Flavonoids, a class of polyphenols with anti‐inflammatory properties, suppress key inflammatory mediators, reducing neutrophilic infiltration and mucosal thickening. These findings suggest flavonoids as potential
Madiha Ajaz, Ayesha Zahid, Hazrat Ismail, Misbah Ajaz   +3 more
wiley   +1 more source

Point-of-care testing for disasters: needs assessment, strategic planning, and future design. [PDF]

, 2009
Objective evidence-based national surveys serve as a first step in identifying suitable point-of-care device designs, effective test clusters, and environmental operating conditions.
Bangs, Bulut, Cazacu, de la Hoz, Dighe, Diiulio, Ender, Farfel, Gerald J. Kost, Ginocchio, Grandjean, Grondhal, Hiransuthikul, Hurt, Ivers, Kazancioglu, Kost, Kost, Kost, Kost, Kost, Kristin N. Hale, Lam, Louie, Lupisan, Millie, MMWR, Nam K. Tran, Nicole L. Gentile, Nishiura, Pabbaraju, Qadri, Rajendran, Richard F. Louie, Schneider, Shaman, Shaman, Sinigalliano, T. Keith Brock, Tao, Thomas, Tyler K. Kitano, Uckay, Vernon, Vollaard   +44 more
core   +1 more source

The Cell Wall ofStreptococcus pneumoniae

Microbiology Spectrum, 2019
ABSTRACT Streptococcus pneumoniae has a complex cell wall that plays key roles in cell shape maintenance, growth and cell division, and interactions with components of the human host. The peptidoglycan has a heterogeneous composition with more than 50 subunits (muropeptides)—products of several peptidoglycan-modifying
Tomasz A, Massidda O, Vollmer W.
openaire   +5 more sources