Results 61 to 70 of about 39,303 (298)

Differential effects of tissue plasminogen activator and streptokinase on infarct size and on rate of enzyme release: influence of early infarct related artery patency: The GUSTO Enzyme Substudy [PDF]

, 2017
Background The recent international GUSTO trial of 41 021 patients with acute myocardial infarction demonstrated improved 90-mm infarct related artery patency as well as reduced mortality in patients treated with an accelerated regimen of tissue ...
Baardman, T., Grollier, G., Hermens, W. Th, Lenderink, T., Molhoek, G. P., Pfisterer, M., Simoons, M. L.   +6 more
core  

Tissue plasminogen activator dose and pulmonary artery pressure reduction in catheter directed thrombolysis of submassive pulmonary embolism. [PDF]

, 2019
PURPOSE:The purpose of this study is to assess the incremental effect of tissue plasminogen activator (t-PA) dose on pulmonary artery pressure (PAP) and bleeding during catheter directed thrombolysis (CDT) of submassive pulmonary embolism (PE). MATERIALS
Gaba, Ron C, Liu, Li, Lokken, R Peter, Patel, Darshan C   +3 more
core   +2 more sources

Continuous deep sedation versus minimal sedation after cardiac arrest and resuscitation (SED‐CARE): A protocol for a randomized clinical trial

Acta Anaesthesiologica Scandinavica, Volume 69, Issue 5, May 2025.
Abstract Background Sedation is often provided to resuscitated out‐of‐hospital cardiac arrest (OHCA) patients to tolerate post‐cardiac arrest care, including temperature management. However, the evidence of benefit or harm from routinely administered deep sedation after cardiac arrest is limited.
A. Ceric, J. Dankiewicz, J. Hästbacka, P. Young, V. H. Niemelä, F. Bass, M. B. Skrifvars, N. Hammond, M. Saxena, H. Levin, G. Lilja, M. Moseby‐Knappe, M. Tiainen, M. Reinikainen, J. Holgersson, C. B. Kamp, M. P. Wise, P. J. McGuigan, J. White, K. Sweet, T. R. Keeble, G. Glover, P. Hopkins, C. Remmington, J. M. Cole, N. Gorgoraptis, D. G. Pogson, P. Jackson, J. Düring, A. Lybeck, J. Johnsson, J. Unden, A. Lundin, J. Kåhlin, J. Grip, E. M. Lotman, L. Romundstad, P. Seidel, P. Stammet, T. Graf, A. Mengel, C. Leithner, J. Nee, P. Druwé, K. Ameloot, A. Nichol, M. Haenggi, M. P. Hilty, M. Iten, C. Schrag, M. Nafi, M. Joannidis, C. Robba, T. Pellis, J. Belohlavek, D. Rob, Y. M. Arabi, S. Buabbas, C. Yew Woon, A. Aneman, A. Stewart, M. Reade, C. Delcourt, A. Delaney, M. Ramanan, B. Venkatesh, L. Navarra, B. Crichton, A. Williams, D. Knight, J. Tirkkonen, T. Oksanen, T. Kaakinen, S. Bendel, H. Friberg, T. Cronberg, J. C. Jakobsen, N. Nielsen   +77 more
wiley   +1 more source

The Effect of Recombinant Tissue Plasminogen Activator (r-tPA) on Quantitation of Neutralising Anti-Streptokinase Antibodies

Iranian Journal of Allergy, Asthma and Immunology, 2004
The measurement of anti-streptokinase antibodies can distinguish the patients who may benefit from streptokinase and those who should be treated with some other thrombolytic regimen.
Afshin Afshari R. Elizbeth Holme
doaj  

Characterization of Streptokinases from Group A Streptococci Reveals a Strong Functional Relationship That Supports the Coinheritance of Plasminogen-binding M Protein and Cluster 2b Streptokinase

Journal of Biological Chemistry, 2012
Background: GAS virulence is dependent on a functional human fibrinolytic system. Results: Functional differences between different strains of GAS streptokinases have been found.
Yueling Zhang, Zhong Liang, Hsing-Tse Hsueh, V. Ploplis, F. Castellino   +4 more
semanticscholar   +1 more source

Fever management with or without a temperature control device after out‐of‐hospital cardiac arrest and resuscitation (TEMP‐CARE): A study protocol for a randomized clinical trial

Acta Anaesthesiologica Scandinavica, Volume 69, Issue 5, May 2025.
Abstract Background Fever is associated with brain injury after cardiac arrest. It is unknown whether fever management with a feedback‐controlled device impacts patient‐centered outcomes in cardiac arrest patients. This trial aims to investigate fever management with or without a temperature control device after out‐of‐hospital cardiac arrest.
Johan Holgersson, V. Niemelä, M. B. Skrifvars, C. Kamp‐Jorgensen, M. Saxena, P. Young, F. Bass, J. Dankiewicz, N. Hammond, J. Hästbacka, H. Levin, G. Lilja, M. Moseby‐Knappe, M. Tiainen, M. Reinikainen, A. Ceric, J. Düring, A. Lybeck, D. Rodriguez‐Santos, J. Johnsson, J. Unden, A. Lundin, J. Kåhlin, J. Grip, J. Rosell, E. M. Lotman, L. Navarra, B. Crichton, D. Knight, A. Williams, L. Romundstad, P. Seidel, P. Stammet, T. Graf, A. Mengel, C. Leithner, J. Nee, P. Druwé, K. Ameloot, M. Wise, J. Riddel, M. Ahmed, M. Buckel, P. Mc Guigan, R. Maharaj, D. Wyncoll, M. Thomas, J. White, T. R. Keeble, D. Pogson, A. Nichol, M. Haenggi, M. P. Hilty, M. Iten, C. Schrag, M. Nafi, M. Joannidis, C. Robba, T. Pellis, J. Belohlavek, O. Smid, D. Rob, Y. Arabi, S. Buabbas, C. Yew Woon, A. Aneman, A. Stewart, S. Bernard, C. Palmer‐Simpson, N. Simpson, M. Ramanan, M. Reade, A. Delaney, B. Venkatesh, J. Tirkkonen, T. Oksanen, T. Kaakinen, S. Bendel, H. Friberg, T. Cronberg, J. Jakobsen, N. Nielsen   +81 more
wiley   +1 more source

Evaluation of In vivo Bioactivity of a Mutated Streptokinase

Novelty in Biomedicine, 2017
 Background: Immunogenicity of Streptokinase, as a thrombolytic drug, has limited its clinical use. Elimination of the amino acid residues that are responsible for immunogenicity while don’t affect the bioactivity of streptokinase is worthy. Recently, we
Marzieh Sameni, Mazaher Gholipourmalekabadi, Mojgan Bandehpour, Mehrdad Hashemi, Farzin Sahebjam, V Tohidi, Bahram Kazemi   +6 more
doaj  

The efficacy and safety of thrombolytic agents for patients with prosthetic valve thrombosis

Journal of the Practice of Cardiovascular Sciences, 2022
Introduction: Prosthetic valve thrombosis (PVT) is a serious complication seen with mechanical prosthetic cardiac valves and is associated with high mortality.
Vinod Sharma, Brig Y K. Arora, Lokesh Chandra Gupta, Amitabh Poonia, Sukriti Raina, Uday Singh Yadav, Ruchi Sharma, S Dwivedi   +7 more
doaj   +1 more source

The Economics of Healthcare Rationing [PDF]

, 2017
This article examines the economics of healthcare rationing. We begin with an overview of the various dimensions across which healthcare rationing operates, or at least has the potential to operate, in the first place.
Frakes, Michael D., Frank, Matthew B., Rozema, Kyle   +2 more
core   +1 more source

Global emergency medicine: A scoping review of the literature from 2023

Academic Emergency Medicine, Volume 32, Issue 5, Page 553-569, May 2025.
Abstract Objective The Global Emergency Medicine Literature Review (GEMLR) highlights the highest‐quality research addressing emergency care in resource‐limited settings (ECRLS). This 18th edition reviews global emergency medicine (GEM) literature published during 2023.
Braden J. Hexom, Nana Serwaa A. Quao, N. Shakira Bandolin, Joseph Bonney, Morgan C. Broccoli, Amanda Collier, Nanaba A. Dawson‐Amoah, Jonathan Dyal, Vinay Kampalath, J. Austin Lee, Chris A. Rees, Gabriel Lucca de Oliveira Salvador, Jonathan M. Strong, Sean M. Kivlehan, on behalf of the Global Emergency Medicine Literature Review (GEMLR) Group, Zainab Ahmed, Kimonia Bih Awanchiri, N. Shakira Bandolin, Emily Bartlett, Nidhi Bhaskar, Corey B. Bills, Joseph Bonney, Morgan C. Broccoli, Whitney K. Bryant, Agatha Brzezinski, Jonathan Chan, Emily Chien, Joseph D. Ciano, Cassandra Clay, Emily Cloessner, Amanda Collier, Emma Cortes, Nanaba A. Dawson‐Amoah, Jonathan W. Dyal, Stephanie Chow Garbern, Reid Haflich, Mohamed F. Hassan, Alison S. Hayward, Braden J. Hexom, Keanoo C. Hill, Anneka Hooft, Jennifer E. Jones, Vinay N. Kampalath, Elizabeth M Keating, Sean M. Kivlehan, Colleen E. Laurence, Joseph Leanza, J. Austin Lee, Gideon Loevinsohn, Rmaah Memon, Mwanja Moses, Dana Naamani, Benjamin D. Nicholson, Hannah Ofosua Owusu, Gerard M. O’Reilly, Mayur Patel, Nana Serwaa A. Quao, Chris A. Rees, Pryanka Relan, Charlotte M. Roy, Megan M. Rybarczyk, Gabriel Lucca de Oliveira Salvador, Anand Selvam, Julia R. Schiff, Jessica Schmidt, Megan L. Schultz, Erin F Shufflebarger, Branden J. Skarpiak, Jonathan M. Strong, Janet Jebichii Sugut, Fadila Tekka, Alex H. Wang, W. Tyler Winders, Tal Berkowitz, Vijaya Arun Kumar, Mallika Manyapu, Daniel Roberts   +76 more
wiley   +1 more source