Results 181 to 190 of about 78,983 (258)

Two distinct alcohol dehydrogenase classes mediate bacterial 2‐hydroxyethylphosphonate catabolism

open access: yesProtein Science, Volume 35, Issue 10, October 2026.
Abstract Phosphonates are molecules containing a direct carbon‐phosphorus bond. In nature, these compounds are produced by a variety of organisms, and many environmental microbes are able to degrade specific phosphonates and feed on them. This work focuses on 2‐hydroxyethylphosphonate (HEP)—a natural compound that is found frequently in the environment,
Francesca Piazza   +8 more
wiley   +1 more source

Piper nigrum Has an Antitumor Effect Through Regulation of the Phosphatidylinositol 3‐Kinase Signaling Pathway in a Murine Model of Acute Myeloid Leukemia

open access: yesPhytotherapy Research, Volume 40, Issue 10, Page 5988-6004, October 2026.
Overview of the antileukemic effects of Piper nigrum extract in AML. P. nigrum reduced leukemic cell proliferation and glycolytic metabolism through modulation of the PI3K/AKT/mTOR pathway. In vivo, treatment reduced leukemic burden, improved hematological parameters, prolonged survival, and modulated antitumor immune responses.
Natalia Murillo   +3 more
wiley   +1 more source

Bacterial Contribution to Hydrogen Peroxide Decomposition in Lake Erie Cyanobacterial Harmful Algal Bloom Communities Is Dependent on Bloom Stage

open access: yesEnvironmental Microbiology Reports, Volume 18, Issue 5, October 2026.
A seasonal time series metatranscriptome dataset suggests that neutralising hydrogen peroxide in Microcystis blooms requires a complex division of labour that is further complicated by seasonality and bloom development. ABSTRACT Cyanobacterial harmful algal blooms (cHABs) are expanding globally and often involve toxin‐producing species such as ...
Chelsea E. Donovan   +9 more
wiley   +1 more source

Ptbp1 Condensates With Phase Separation‐Like Features in Cardiomyocyte Nuclei Regulate Splicing of Proliferative Genes in Neonatal Cardiomyocytes

open access: yesDevelopment, Growth &Differentiation, Volume 68, Issue 8, October 2026.
Phase‐separated Ptbp1 droplets form molecular complexes containing multiple proliferation‐associated molecules. Ptbp1 granules containing four RNA recognition motifs (RRMs) domains are present in the nuclei of mouse cardiomyocytes specifically during the proliferative stage.
Tai Sada   +7 more
wiley   +1 more source

Toward understanding the catalytic mechanism for two classes of bacterial phospholipid N‐methyltransferases

open access: yesThe FEBS Journal, Volume 293, Issue 20, Page 6253-6271, October 2026.
Phospholipid N‐methyltransferases (Pmts) synthesize phosphatidylcholine in many bacteria. In this study, we compared the catalytic mechanisms of two bacterial Pmt classes: the Rhodobacter (R‐) and the Sinorhizobium (S‐) type. Representative enzymes for each class were derived from Rubellimicrobium thermophilum and Agrobacterium tumefaciens ...
Irina Shevyreva   +5 more
wiley   +1 more source

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