Results 111 to 120 of about 1,344 (153)

Genetically engineered Streptomyces viridosporus ATCC 14672 strains for the discovery of novel moenomycins. [PDF]

Sci Rep
Ostash B, Makitrynskyy R, Fedchyshyn M, Luzhetskyy A, Walker S, Fedorenko V.   +5 more
europepmc   +1 more source

Peptide surfactants with post-translational C-methylations that promote bacterial development. [PDF]

Nat Chem Biol
Zhang C, Li Y, Overton EN, Seyedsayamdost MR.   +3 more
europepmc   +1 more source

Enhancing microbial metabolic capacity through high-energy electron beam-induced intense structural variations. [PDF]

Nat Commun
Feng X, Li Z, Zhang Y, Xu J, Xin Z, Yang J, Wu M, Zhang S, Yu Z, Qu D, He T, Wu J, Yu J, Liu W, Seyedsayamdost MR, Wang W, Xu F.   +16 more
europepmc   +1 more source

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Isolation and characterization of a linear DNA plasmid from Streptomyces clavuligerus

Molecular Genetics and Genomics, 1988
A linear DNA plasmid (pSCL) has been isolated from Streptomyces clavuligerus by a method employing high concentrations of protease. Rate-zonal sedimentation on sucrose gradients was used to purify the plasmid. The plasmid is 12 kb in length and appears to be linked to protein at its 5' termini.
K L Roy, Yair Aharonowitz, Cohen Gerald   +2 more
exaly   +3 more sources

Ammonium repression of cephalosporin production by Streptomyces clavuligerus

Canadian Journal of Microbiology, 1985
Production of β-lactam antibiotics took place during growth of Streptomyces clavuligerus in chemically defined medium. The specific activities of isopenicillin N synthetase ("cyclase"), isopenicillin N epimerase, and deacetoxycephalosporin C synthetase ("expandase") increased during the exponential phase of growth.
A F, Braña, S, Wolfe, A L, Demain
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Cephamycin Production by Streptomyces Clavuligerus

1991
The classical β-lactam antibiotics can be divided into hydrophobic and hydrophilic fermentation products. The hydrophobic members, e.g. benzylpenicillin (penicillin G) and phenoxymethylpenicillin (penicillin V), contain non-polar side chains, e.g. phenylacetate and phenoxyacetate, respectively, and are made only by filamentous fungi; the best known of ...
A. L. Demain, J. M. Piret
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Improvement for the production of clavulanic acid by mutant Streptomyces clavuligerus

Letters in Applied Microbiology, 2002
To improve the production of clavulanic acid through the development of strains, the selection of a production medium and a pH shift strategy in a bioreactor.Streptomyces clavuligerus mutant 15 was selected by antibacterial activities. As a result of pH control in a 2.5 l bioreactor, the highest productivity (3.37 microg x ml(-1) x h(-1)) was obtained ...
S D, Lee, S W, Park, K K, Oh, S I, Hong, S W, Kim   +4 more
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Lysine catabolism and α-aminoadipate synthesis in Streptomyces clavuligerus

Applied Microbiology and Biotechnology, 1991
The intracellular α-aminoadipic acid pool in Streptomyces glavuligerus mycelium growing in a starch-peptone medium decreased during the late exponential and stationary phases when cephamycin was being produced; however, the amino acid accumulated extracellularly.
K, Madduri, S, Shapiro, A C, Demarco, R L, White, C, Stuttard, L C, Vining   +5 more
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Kinetic analysis of cephalosporin biosynthesis in Streptomyces clavuligerus

Biotechnology and Bioengineering, 1991
AbstractA kinetic model describing the cephalosporin biosynthesis in Streptomyces clavuligerus was developed. Using previously reported kinetic data of biosynthetic enzymes, we examined the kinetics of cephalosporin production. The predicted time profile of the specific production rate during a batch culture parallels that of experimental observation ...
L H, Malmberg, W S, Hu
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Holomycin, a dithiolopyrrolone compound produced by Streptomyces clavuligerus

Applied Microbiology and Biotechnology, 2013
Holomycin is a member of the dithiolopyrrolone class of secondary metabolites. It contains a cromophore formed by two heterocycles, one of them carrying a disulfide bridge. The holomycin chromophore is also present in thioluthin, aureothricin, the xenorhabdins and the complex thiomarinols.
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