Results 91 to 100 of about 981,404 (392)

Cell aging preserves cellular immortality in the presence of lethal levels of damage. [PDF]

, 2019
Cellular aging, a progressive functional decline driven by damage accumulation, often culminates in the mortality of a cell lineage. Certain lineages, however, are able to sustain long-lasting immortality, as prominently exemplified by stem cells.
Chao, Lin, Proenca, Audrey Menegaz, Qiu, Andrew, Rang, Camilla Ulla, Shi, Chao   +4 more
core   +3 more sources

Chimeric diphtheria toxin–CCL8 cytotoxic peptide for breast cancer management

Molecular Oncology, EarlyView.
DTCCL8 is a recombinant fusion toxin that targets cancer cells expressing chemokine receptors. By combining diphtheria toxin with CCL8, DTCCL8 binds to multiple receptors on tumor cells and induces selective cytotoxicity. This strategy enables receptor‐mediated targeting of cancer and may support the development of chemokine‐guided therapeutics ...
Bernardo Chavez, Asieh Naderi, Kim‐Tuyen Huynh‐Dam, Vitali Sikirzhytski, Ioulia Chatzistamou, Hippokratis Kiaris   +5 more
wiley   +1 more source

An Overview on Recent Progress in Electrochemical Biosensors for Antimicrobial Drug Residues in Animal-Derived Food

Sensors, 2017
Anti-microbial drugs are widely employed for the treatment and cure of diseases in animals, promotion of animal growth, and feed efficiency. However, the scientific literature has indicated the possible presence of antimicrobial drug residues in animal ...
Marjan Majdinasab, Mustansara Yaqub, Abdur Rahim, Gaelle Catanante, Akhtar Hayat, Jean Louis Marty   +5 more
doaj   +1 more source

Chicken faecal microbiota and disturbances induced by single or repeated therapy with tetracycline and streptomycin

BMC Veterinary Research, 2013
BackgroundIn this study, we characterised the microbiota present in the faeces of 15- and 46-week-old egg laying hens before and after tetracycline or streptomycin therapy. In the first experiment, the layers were subjected to 7 days of therapy.
P. Videnska, M. Faldynova, H. Juřicová, V. Babak, F. Sisak, H. Havlíčková, I. Rychlík   +6 more
semanticscholar   +1 more source

Streptomycin ototoxicity in the unborn child [PDF]

, 1981
The original publication is available at http://www.samj.org.zaStreptomycin has been used in pregnant patients for more than 30 years. Some doubt, however, still exists with regard to its effects on the ear of the unborn child.
Donald, P. R., Sellars, S. L.
core  

Optimizing adipogenic transdifferentiation of bovine mesenchymal stem cells: a prominent role of ascorbic acid in FABP4 induction [PDF]

, 2020
Adipocyte differentiation of bovine adipose-derived stem cells (ASC) was induced by foetal bovine serum (FBS), biotin, pantothenic acid, insulin, rosiglitazone, dexamethasone and 3-isobutyl-1-methylxanthine, followed by incubation in different media to ...
Aschenbach, Jörg R., Bermúdez- Peña, M. Carmen, Jurek, Sandra, Kolisek, Martin, Sandhu, Mansur A., Sponder, Gerhard, Trappe, Susanne   +6 more
core   +1 more source

ITGAV and SMAD4 influence the progression and clinical outcome of pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
In SMAD4‐positive pancreatic ductal adenocarcinoma (PDAC), integrin subunit alpha V (ITGAV) activates latent TGF‐β, which binds to the TGF‐β receptor and phosphorylates SMAD2/3. The activated SMAD2/3 forms a complex with SMAD4, and together they translocate to the nucleus, modulating gene expression to promote proliferation, migration, and invasion. In
Daniel K. C. Lee, Keyue Chen, Ryan Loke, Xiang Li, David Liubart, Golam T. Saffi, Jonathan T. S. Chow, Ché M. P. Melo, Lydia To, Leonardo Salmena   +9 more
wiley   +1 more source

Exploring the role of cyclin D1 in the pathogenesis of multiple myeloma beyond cell cycle regulation

Molecular Oncology, EarlyView.
Cyclin D1 overexpression altered the cell adhesion pathway, while cyclin D2 upregulation had less impact on pathway enrichment analysis. Multiple myeloma (MM) patients with cyclin D1 overexpression showed reduced CD56 expression and increased circulating tumor cells (CTC) levels, suggesting that cyclin D1 may contribute to MM cell dissemination ...
Ignacio J. Cardona‐Benavides, Sara Cristobal‐Vargas, Cristina De Ramón, Elizabeta A. Rojas, Irena Misiewicz‐Krzeminska, Isabel Isidro, José Juan Pérez, Bruno Paiva, Noemi Puig, Miguel Alcoceba, María‐Victoria Mateos, Luis A. Corchete, Myriam Cuadrado, Norma C. Gutiérrez   +13 more
wiley   +1 more source

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

Nurses\u27 Alumnae Association Bulletin - Volume 6 Number 9 [PDF]

, 1948
Remember the Relief Fund Welcome! Miss Childs Financial Report Calendar of Coming Events Lest You Forget! Attention Review of the Alumnae Association Meetings Institutional Staff Nurses\u27 Section Report of Staff Activities - 1947-1948 Private Duty ...
Allbritton, Frank F, Bauer, Mrs. Edward L, Beatty, Dorothy M, Bonenberger, Mary, Carey, Margaret A, Childs, Katherine, Dute, Evelyn, Erf, Lowell, Flack, Henrietta L, Montgomery, Thaddeus L, Piersol, Betty, Price, Allison, Ranck, Dorothy, Shoemaker, Nora E, Spruance, Henrietta F, Walker, Martha, Walters, Elsie M   +16 more
core   +1 more source