Results 71 to 80 of about 737,951 (291)

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

Horizontal gene transfer and evolution of antibiotic gene clusters [PDF]

Genome sequencing projects from diverse bacteria and the release of genetically engineered microorganisms make the topic of horizontal gene transfer (HGT) fashionable.
Kallifidas, Dimitrios
core  

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

Influence of Perfluorodecalin on Growth of Actinomycetes and Intensification of Streptomycin and Daunorubicin Production by the Genus Streptomyces Kind Bacteria in Submerged Culture

Антибиотики и Химиотерапия, 2020
Addition of perfluorodecalin with gas-transporting function to the liquid medium during submerged cultivation of actinomycetes of the genus Streptomyces resulted in higher intensity and level of the biomass synthesis and increased production of ...
V. M. Bakulin, A. S'. Tumanov, E. A. Martinson, S. G. Litvinec, M. K. Bakulin, V. B. Kalininski   +5 more
doaj  

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

Green synthesis, characterization and drug-loaded iron oxide nanoparticles derived from Nerium oleander flower extract as a nanocarrier for in vitro antibacterial efficacy

Nano Express
Application of drug conjugated iron oxide hematite ( α -Fe _2 O _3 ) nanoparticles are of tremendous interest in biomedicine nowadays. Meanwhile, green production of iron oxide nanoparticles is gaining favour due to its sustainability, ease of usage, and
Vandana Sharma, J K Sharma, Vishal Kansay, Aarzoo Dutta, Mayank Raj, Manoj Singh, Anu Kapoor, Chhavi Pahwa, Anupam Sharma, Suresh Kumar, A K Sharma, M K Bera   +11 more
doaj   +1 more source

Impact of different antibiotic treatments on pregnancy maintenance in Holstein Friesian cows infected with foot-and-mouth disease

Ovozoa: Journal of Animal Reproduction
This study was conducted at Setia Kawan dairy cattle farming cooperative in Nongkojajar, Pasuruan, East Java to evaluate the effects of different antibiotic treatments on pregnancy sustainability in Holstein Friesian (HF) dairy cows infected with foot ...
Vensko Zico Dandi Wahyu Pratama, Jola Rahmahani, Herry Agoes Hermadi, Nusdianto Triakoso, Kadek Rachmawati   +4 more
doaj   +1 more source

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source

Microbiological, histological, immunological, and toxin response to antibiotic treatment in the mouse model of Mycobacterium ulcerans disease. [PDF]

, 2013
Mycobacterium ulcerans infection causes a neglected tropical disease known as Buruli ulcer that is now found in poor rural areas of West Africa in numbers that sometimes exceed those reported for another significant mycobacterial disease, leprosy, caused
Jacques H Grosset, Deepak V Almeida, Robinson, C, Sarfo, FS, Jihui Zhang, Almeida, DV, Paul J Converse, Clive Robinson, Wansbrough-Jones, M, Mark Wansbrough-Jones, Grosset, JH, Fred Stephen Sarfo, Converse, PJ, Zhang, J   +13 more
core   +1 more source