Results 81 to 90 of about 950,370 (305)
Molecular Oncology, EarlyView.Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
wiley +1 more source
Short-Course Chemotherapy for Tuberculosis [PDF]
, 2005 Annotated and edite transcript of a Witness Seminar held on 3 February 2004. Introduction by Dr Linda Bryder, University of Auckland.First published by the Wellcome Trust Centre for the History of Medicine at UCL, 2005. ©The Trustee of the Wellcome Trust,
Christie, DA, Tansey, EM
core
Specialized mouse embryonic stem cells for studying vascular development. [PDF]
, 2014 Vascular progenitor cells are desirable in a variety of therapeutic strategies; however, the lineage commitment of endothelial and smooth muscle cell from a common progenitor is not well-understood.
Burns, Andrew B +5 more
core +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Detection of streptomycin residues in local meat of bovine and ovine [PDF]
, 2011 From meat retails in Mosul province, forty-five meat samples of local ovine and bovine (23 bovine samples and 22 ovine samples) were collected. The period of collection was during November 2010 to May 2011, by means of multistage random sampling for ...
A. M. Shareef +2 more
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E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer
Molecular Oncology, EarlyView.Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov +3 more
wiley +1 more source
Conjugative transfer of ICESde3396 between three β-hemolytic streptococcal species [PDF]
, 2014 Background: Integrative conjugative elements (ICEs) are mobile genetic elements (MGEs) that possess all genes necessary for excision, transfer and integration into recipient genome. They also carry accessory genes that impart new phenotypic features to
Bauer, Michelle J. +6 more
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Molecular Oncology, EarlyView.Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau +8 more
wiley +1 more source
Selman Abraham Waksman — a Great Scientist and One of the Greatest Benefactors of Mankind
Aktualʹnaâ Infektologiâ, 2015 The article presents in chronological order the main aspects of the discovery of the first antituberculous drug — streptomycin and information about Nobel Prize winner in physiology and medicine of Ukrainian origin — Selman Abraham Waksman.
D.V. Rotar
doaj +1 more source
Antibiotic residues and R-plasmid selection: are in vitro methods good models? [PDF]
, 1987 Three clones of E. coli, one of which was harbouring a tetracycline resistance plasmid were inoculated together into the stomach of axenic mice. Without antibiotic selective pressure, the R-Plasmid bearing strain became dominant in the faeces of mice ...
Corpet, Denis E., Lumeau, Solange
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