Results 101 to 110 of about 988,438 (327)

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

A method for isolating and culturing placental cells from failed early equine pregnancies [PDF]

, 2016
Early pregnancy loss occurs in 6–10% of equine pregnancies making it the main cause of reproductive wastage. Despite this, reasons for the losses are known in only 16% of cases.
A.J. McGladdery, A.M. de Mestre, Allen, B.V. Rose, C. Smith, Cabrera-Sharp, D.C. Wathes, de Mestre, Diskin, F.E. Barrelet, Greenwold, H. Neal, Hamstead, I.J. Cameron, Inskeep, J. Crowhurst, J. Pynn, J.R. Crabtree, K.L.P. Verheyen, Lanoix, M.J. Firth, O.D. Pynn, Oriol, Petracchi, Raudsepp, Robbin, S. Bate, Seo, Strand, V. Cabrera-Sharp, Vanderwall, Z. Wise   +31 more
core   +2 more sources

The Effects of Local Streptomycin/lidocaine Injections on Treatment of Carbamazepine Resistant Trigeminal Neuralgia

Journal of Mazandaran University of Medical Sciences, 2018
Background and purpose: Trigeminal neuralgia is the most common type of facial neuralgia. The pain would easily affect the quality of life according to its acute and severe nature. Treatment modalities include pharmacotherapy, microvascular decompression,
Amir Hooman Sadr Haghighi, Seyed ahmad Arta, Mohammad Hossein Ahangar Atashi, Tannaz Abdollahzadeh Baghaei   +3 more
doaj  

Synthesis, Anti-microbial and Molecular Docking Studies of Quinazolin-4(3H)-one Derivatives

Molecules, 2014
In this work, synthesis, antimicrobial activities and molecular docking studies of some new series of substituted quinazolinone 2a–h and 3a–d were described.
Yahia Nasser Mabkhot, Munirah S. Al-Har, Assem Barakat, Fahad D. Aldawsari, Ali Aldalbahi, Zaheer Ul-Haq   +5 more
doaj   +1 more source

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Synergistic effect of silver nanoparticles with streptomycin on the streptomycin-resistant Brucella abortus [PDF]

, 2013
زمینه و هدف: بروسلا (Brucella) عامل یک‌ بیماری‌ عفونی با درمان سخت‌ است‌ که با گسترش مقاومت دارویی و عود مجدد عفونت، پس از درمان روبروست. همچنین اثرات جانبی مصرف آنتی‏بیوتیک‏هایی که برای درمان به کار می‌روند بسیار بالاست.
Erfani, Mohammad., mirnejad, Reza., piranfar, Vahab., Sadeghi, Babak.   +3 more
core  

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Genotyping and antimicrobial resistance patterns of Escherichia coli O157 originating from cattle farms [PDF]

, 2011
During a Escherichia coli O157 prevalence study on cattle farms, 324 E. coli O157 isolates were collected from 68 out of 180 cattle farms. All isolates harbored the eaeA gene and the enterohemolysin (ehxA) gene. The majority of the strains only contained
Boyen, Filip, Cobbaut, Katrijn, De Zutter, Lieven, Haesebrouck, Freddy, Houf, Kurt   +4 more
core   +1 more source

Restricted streptomycin use in apple orchards did not adversely alter the soil bacteria communities

Frontiers in Microbiology, 2014
Streptomycin has been authorized for restricted use in the prevention of the fire blight disease of pome fruit orchards in the EU and Switzerland. This study addresses the important topic of the influence of the use of streptomycin in agriculture on the ...
F. Walsh, Daniel Patrick Smith, S. Owens, B. Duffy, J. Frey   +4 more
semanticscholar   +1 more source

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source