Results 161 to 170 of about 981,404 (392)

Blocking the voltage‐gated sodium channel hNav1.5 as a novel pH‐dependent mechanism of action for tamoxifen

FEBS Open Bio, EarlyView.
Patch‐clamp recordings revealed that tamoxifen inhibits voltage‐gated sodium channels, especially under acidic conditions, both common in metastatic cancer cells. These effects may explain certain antitumor properties of tamoxifen, highlighting a novel mechanism of action beyond its known endocrine effects.
Karl Josef Föhr, Michael Fauler, Thomas Zimmer, Bettina Jungwirth, Hubert Schrezenmeier, David Alexander Christian Messerer   +5 more
wiley   +1 more source

ANTIGENIC AND ENZYME SYSTEM CHANGES IN BETA HEMOLYTIC STREPTOCOCCI RESISTANT TO PENICILLIN, STREPTOMYCIN, BACITRACIN AND AUREOMYCIN 1234 [PDF]

, 1949
Horace M. Gezon, Dorcas M. Fasan
openalex   +1 more source

Using long‐term experimental evolution to uncover the patterns and determinants of molecular evolution of an Escherichia coli natural isolate in the streptomycin‐treated mouse gut

Molecular Ecology, 2017
M. Lescat, Adrien Launay, M. Ghalayini, M. Magnan, Jérémy Glodt, Coralie Pintard, S. Dion, E. Denamur, O. Tenaillon   +8 more
semanticscholar   +1 more source

Impact of Vegetative Treatment Systems on Multiple Measures of Antibiotic Resistance in Agricultural Wastewater [PDF]

, 2018
Wastewater is an important vector of antibiotic resistant bacteria and antibiotic resistance genes (ARB/G). While there is broad agreement that ARB/G from agricultural (ag) wastewaters can be transported through the environment and may contribute to ...
Durso, Lisa M., Henry, Christopher G., Miller, Daniel N.   +2 more
core   +1 more source

The cochaperone BAG3 promotes the stabilization of p53 under heat stress conditions

FEBS Open Bio, EarlyView.
Under heat stress, BAG3 translocates to the nucleus and forms a complex with Hsp70 and p53, thereby promoting p53 stabilization and enhancing its transcriptional activity. These findings suggest that BAG3 functions as a cochaperone that supports p53‐mediated stress responses in cooperation with Hsp70.
Ngoc Nguyen Thi Minh, Esther Lee, Soo‐A Kim   +2 more
wiley   +1 more source

The Clinical Aspects of the Streptomycin Treatment of Pulmonary Tuberculosis

, 1950
John Bignall
openalex   +1 more source

Downregulation of sST2, a decoy receptor for interleukin‐33, enhances subcutaneous tumor growth in murine pancreatic cancer cells

FEBS Open Bio, EarlyView.
Subcutaneous implantation of murine Panc02 pancreatic cancer cells depleted of sST2, a soluble decoy receptor for the proinflammatory interleukin‐33 (IL‐33), leads to a decreased number of GLUT4‐positive cancer‐associated adipocytes, reduced levels of the anti‐inflammatory molecule adiponectin, increased phosphorylation of IκBα, elevated Cxcl3 ...
Miho Akimoto, Nobuko Koshikawa, Takao Morinaga, Mimi Tamamori‐Adachi, Atsushi Takatori, Keizo Takenaga   +5 more
wiley   +1 more source

Fertility of Diluted Bull Semen Containing 100 Micro-Grams of Streptomycin Per Milliliter

, 1950
H. L. Easterbrooks, Philip H. Heller, W. N. Plastridge, E. L. Jungherr, F.I. Elliott   +4 more
openalex   +1 more source

The evolution of no-cost resistance at sub-MIC concentrations of streptomycin in Streptomyces coelicolor

The ISME Journal, 2016
S. Westhoff, Tim M. van Leeuwe, Omar I. Qachach, Zheren Zhang, G. P. Wezel, D. Rozen   +5 more
semanticscholar   +1 more source

Statins induce monocytic differentiation in acute myeloid leukemia cells through the KLF4/DPYSL2A axis

FEBS Open Bio, EarlyView.
Statins, identified via the Comparative Toxicogenomics Database, promote monocytic differentiation and apoptosis in non‐APL AML cells by upregulating DPYSL2A through a KLF4‐dependent pathway. Mevalonate supplementation reversed these effects, indicating involvement of the mevalonate pathway.
Mina Noura, Kota Shoji, Michidai Nobe, Moe Ishikawa, Miu Tanaka, Akiko Okayama, Souichi Adachi, Hidemasa Matsuo   +7 more
wiley   +1 more source