Results 11 to 20 of about 13,291 (204)

Responses to medical treatment in patients with metastatic unresectable small intestinal neuroendocrine tumors - A single center study of 378 patients. [PDF]

J Neuroendocrinol
Abstract Small intestinal neuroendocrine tumors (siNET) are rare malignancies, often diagnosed at advanced stages with metastatic spread. While surgery is the only curative treatment, medical therapies, including somatostatin analogues (SSA), peptide receptor radionuclide therapy (PRRT), and other systemic treatments, are essential for disease ...
Slott C, Langer SW, Oturai P, Møller S, Hansen CP, Kjaer A, Holmager P, Klose M, Garbyal RS, Knigge U, Andreassen M.   +10 more
europepmc   +2 more sources

Targeting Oxidative Stress and Apoptosis via PI3K/Akt/Nrf2 Pathway: The Therapeutic Role of Bletilla striata Polysaccharide in Diabetic Wound Repair. [PDF]

J Diabetes Res
Background Diabetic wounds are challenging and lack efficient therapeutic solutions. Bletilla striata polysaccharide (BSP) has garnered interest for its bioactivity and antioxidant ability in wound healing. This research explores the mechanisms through which BSP alleviates oxidative stress (OS) in L929 cells and prevents cell apoptosis under high ...
Xu S, Ni Z, Zhang T, Zhang X, Li X, Bai L, Yu L, Xu G.   +7 more
europepmc   +2 more sources

Endothelial βII Spectrin Deletion Exacerbates Inflammation and Impairs Tissue Regeneration in Ischemic-Diabetic Skin Wound Healing. [PDF]

Wound Repair Regen
ABSTRACT Impaired lower extremity wound healing due to diabetes presents a significant societal burden, as 25% of diabetic wounds lead to major amputations. While TGF‐β has been extensively studied in diabetic wound healing, the role of βII spectrin (SPTBN1), a known adapter of SMAD3 in the canonical TGF‐β signalling pathway, remains unexplored. Single‐
Gupta R, Cooper PO, Chai W, Mulagura P, Lee SM, Theocharidis G, Sidawy AN, Shook BA, Nguyen BN.   +8 more
europepmc   +2 more sources

Slowly Digestible Carbohydrate Diet Ameliorates Hyperglycemia and Hyperlipidemia in High-Fat Diet/Streptozocin-Induced Diabetic Mice

Frontiers in Nutrition, 2022
ObjectiveGiven that the prevalence rate of type 2 diabetes mellitus (T2DM) continues to increase, it is important to find an effective method to prevent or treat this disease. Previous studies have shown that dietary intervention with a slowly digestible
Yu-Zhong Chen, Jia Gu, Wei-Ting Chuang, Ya-Fang Du, Lin Zhang, Meng-Lan Lu, Jia-Ying Xu, Hao-Qiu Li, Yan Liu, Hao-Tian Feng, Yun-Hong Li, Li-Qiang Qin   +11 more
doaj   +1 more source

Effect of Combined Leaf Extracts of Vernonia amygdalina (Bitter Leaf) and Gongronema latifolium (Utazi) on the Pancreatic beta-Cells of Streptozotocin- Induced Diabetic Rats [PDF]

, 2011
The study evaluated the effect of combined extracts of Vernonia amygdalina (VA) and Gongronema latifolium (GL) on the pancreas of streptozotocin (STZ) induced diabetic Wistar rats. Thirty-two (32) albino rats were divided equally into 4 groups.
Akpantah, Amabe, Akpaso, Mfon I, Atangwho, Item J, Ebong, Patrick E, Fischer, Victor A, Igiri, Anozeng O.   +5 more
core   +1 more source

Effect of mesenchymal stem cells and polyvinyl alcohol-coated selenium nanoparticles on rats with Alzheimer-like phenotypes [PDF]

Iranian Journal of Basic Medical Sciences
Objective(s): Mesenchymal stem cell (MSC) transplantation represents a promising approach for treating Alzheimer’s disease (AD). These stem cells, however, have a short lifespan following transplantation into recipient animals.
Siamak Shahidi, Sara Soleimani Asl, Bahareh Gholamigeravand, Simimn Afshar, Nasrin Hashemi-Firouzi, Alireza Samzadeh-Kermani, Mahsa Majidi, Kimia Amiri   +7 more
doaj   +1 more source

Treatment options for PNET liver metastases. a systematic review [PDF]

, 2018
Pancreatic neuroendocrine tumors (PNETs) are rare pancreatic neoplasms. About 40-80% of patients with PNET are metastatic at presentation, usually involving the liver (40-93%). Liver metastasis represents the most significant prognostic factor.
Aurello, Paolo, Crovetto, Anna, Debs, Tarek, Mangogna, Livia Maria, Moschetta, Giovanni, Nigri, Giuseppe, Persechino, Raffaello, Petrucciani, Niccolò, Ramacciato, Giovanni   +8 more
core   +1 more source

Therapeutic sequences in patients with grade 1−2 neuroendocrine tumors (NET): an observational multicenter study from the ELIOS group [PDF]

, 2019
Purpose: Many different treatments are suggested by guidelines to treat grade 1−2 (G1−G2) neuroendocrine tumors (NET). However, a precise therapeutic algorithm has not yet been established.
Badalamenti, G., Bianco, A., Colao, A., De Divitiis, C., Di Maio, S., Di Sarno, A., Dolce, P., Faggiano, A., Guarnotta, V., Leo, S., Mocerino, C., Modica, R., Ottaviano, M., Palmieri, G., Puliafito, I., Riccardi, F., Tafuto, S., Tozzi, L.   +17 more
core   +1 more source

Streptozotocin - an antibiotic used to induce diabetes on experimental animals

Journal of Education, Health and Sport, 2020
Streptozotocin (STZ) is a cytostatic antibiotic produced by Streptomyces achromogenes. It is an inhibitor of DNA replication showing a special affinity for pancreatic β-cells DNA.
Dagna Siedlecka, Wojciech Micał, Ewa Krzewicka-Romaniuk   +2 more
doaj   +1 more source

Increased airway glucose increases airway bacterial load in hyperglycaemia. [PDF]

, 2016
Diabetes is associated with increased frequency of hospitalization due to bacterial lung infection. We hypothesize that increased airway glucose caused by hyperglycaemia leads to increased bacterial loads.
A Pezzulo, A Pezzulo, AM Rueda, AW Hitchings, B Krismer, B Philips, B Philips, B Vandanmagsar, B Williams, BW Holloway, D Nguyen, E Baker, EH Baker, GL Winsor, HJ Kim, J Garnett, JM van den Berg, JP Garnett, K Hodgson, K Kalsi, K Mathee, KK Kalsi, M Silby, M Valentini, MC Deeds, MK Siggins, P Mancuso, PC Reading, RJ Lee, S Ruer   +29 more
core   +1 more source