Streptozotocin - an antibiotic used to induce diabetes on experimental animals
Journal of Education, Health and Sport, 2020 Streptozotocin (STZ) is a cytostatic antibiotic produced by Streptomyces achromogenes. It is an inhibitor of DNA replication showing a special affinity for pancreatic β-cells DNA.
Dagna Siedlecka +2 more
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ANTIHYPERGLYCEMIC ACTIVITY OF PITHECELLOBIUM DULES PLANT EXTRACTS ON BLOOD GLUCOSE LEVELS OF STREPTOZOCIN-INDUCED DIABETIC RATS [PDF]
, 2018 Background: The prevalence of diabetes mellitus continues to rise worldwide and treatment with oral hypoglycemic drugs leads to numerous side effects and huge monetary expenditure.
Ashutosh Upadhayay +7 more
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Adiponectin Fails in Improving Angiogenic Repair in Streptozocin-Treated or Lepr db/db Mice after Hind Limb Ischemia [PDF]
, 2012 peer reviewedType 1 and 2 diabetes carry risk factors for the development of microvascular diseases with associated impairment of angiogenic repair. Here, we investigated whether adiponectin, an adipocyte-specific adipocytokine with antiatherosclerotic ...
Schiekofer, Stephan +3 more
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Capillary area in early low-dose streptozocin-treated mice [PDF]
, 1990 It has been reported that vasoconstriction of intra-islet capillaries plays an important role in the initiation of the insulitis seen in the islets of Langerhans of diabetic animals.
MEZZOGIORNO V +3 more
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Archives of Plastic Surgery, 2014 Background Autologous fat grafts have been widely used for cosmetic purposes and for soft tissue contour reconstruction. Because diabetes mellitus is one of the major chronic diseases in nearly every country, the requirement for fat grafts in diabetes ...
Jae A Jung +3 more
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Methyl-CCNU, 5-fluorouracil, vincristine, and streptozocin (MOF-STREP) in metastatic colo-rectal carcinoma. [PDF]
, 1983 Forty patients with metastatic colorectal carcinoma who had received no prior chemotherapy were entered onto a trial of methyl-CCNU, 5-fluorouracil, vincristine, and streptozocin (MOF-STREP). Ten of 40 (25%) responded.
D J Perry, M D Weltz, J Blom, W M Butler
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Modeling of age-dependent disorders: relationship between the nervous and endocrine systems
Анналы клинической и экспериментальной неврологии, 2018 Age-dependent disorders are a challenging problem of modern society. Among the most significant age-dependent disorders are Alzheimer's disease (AD), diabetes, metabolic syndrome, etc.; these conditions may be associated to each other and have, at least ...
Alla V. Stavrovskaya +6 more
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The immunosuppressant FK506 inhibits the damage to mouse pancreatic islets induced by low dose streptozocin [PDF]
, 1994 Diabetes mellitus was induced in 40 male C57BL6 mice by injection of a low dose of streptozocin (45 mg/kg body weight) on 5 consecutive days. Twenty four of the mice were immunosuppressed by administration of 1.5 mg FK506/kg body weight daily for 10, 15,
CHIEFFI, Gabriella +2 more
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Medical Laboratory Journal, 2023 Background and objectives: Gentamicin is an aminoglycoside antibiotic used in the treatment of Gram-negative bacterial infections. One of the side effects of this antibiotic is nephrotoxicity. In this study, the protective effect of Melissa officinalis L.
Ali Reza Nasiri, Amir Reza Karamibonari
doaj
Structural and mechanistic studies on the biosynthesis of streptozocin [PDF]
, 2021 N-nitroso containing natural products, which contain the core structure −N−N=O, can act as both chemotherapeutics and as carcinogens due to their ability to alkylate DNA.
Henderson, Alyssa
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