Results 31 to 40 of about 8,719 (217)

Molecular mechanism of ischemic postconditioning in promoting diabetic ischemic brain injury repair via the microRNA‐34a–BDNF–SIX3 signaling axis

Animal Models and Experimental Medicine, EarlyView.
Diabetes combined with ischemic stroke (DMIS) exacerbates brain infarct size and neuronal damage compared to nondiabetic ischemic stroke (IS). This study reveals that microRNA‐34a (miR‐34a) plays a key role in DMIS pathogenesis: miR‐34a directly targets and suppresses brain‐derived neurotrophic factor (BDNF) and Sine oculis homeobox 3 (SIX3), promoting
Ling Zhao, Chunlan Zou, Junxian Li, Yang Yang, Yuanyuan Han, Tingyu Ke   +5 more
wiley   +1 more source

A New Vista of Opportunity in Diabetes Management: Natural Product‐Based β‐cell Preservation

Food Chemistry International, EarlyView.
Preserving functional β‐cells via natural products offers promising strategy for diabetes treatment. ABSTRACT A defining characteristic of diabetes is β‐cell failure, in which β‐cells cannot modulate insulin secretion to compensate for escalating insulin resistance, pushing forward disease development.
Yi‐San Lee, Tien‐Fen Kuo, Chun‐Yen Yang, Greta Yang, Wen‐Chin Yang   +4 more
wiley   +1 more source

ANTIHYPERGLYCEMIC ACTIVITY OF PITHECELLOBIUM DULES PLANT EXTRACTS ON BLOOD GLUCOSE LEVELS OF STREPTOZOCIN-INDUCED DIABETIC RATS

, 2018
Background: The prevalence of diabetes mellitus continues to rise worldwide and treatment with oral hypoglycemic drugs leads to numerous side effects and huge monetary expenditure.
Ashutosh Upadhayay, Kumari, Sadhana, Shalini, Shalini, Shalini Shalini, Jayabalan Govindaswami, Upadhayay, Ashutosh, Govindaswami, Jayabalan, Sadhana Kumari   +7 more
core   +1 more source

Crystal structure of rubidium methyldiazotate

Acta Crystallographica Section E: Crystallographic Communications, 2017
The title compound, Rb+·H3CN2O−, has been crystallized in liquid ammonia as a reaction product of the reductive ammonolysis of the natural compound streptozocin. Elemental rubidium was used as reduction agent as it is soluble in liquid ammonia, forming a
Tobias Grassl, Nikolaus Korber
doaj   +1 more source

Is there a role for cannabidiol in obesity, metabolic syndrome and binge eating?

British Journal of Pharmacology, EarlyView.
Cannabidiol (CBD) is one of the most abundant phytocannabinoids isolated from the Cannabis sativa plant. CBD is a lipophilic, non‐intoxicating substance that differently from Δ9‐tetrahydrocannabinol (Δ9‐THC) does not present the typical profile of a drug of abuse.
Luca Botticelli, Emanuela Micioni Di Bonaventura, Giacomo Einaudi, Gustavo Provensi, Alessia Costa, Claudio D'Addario, Carlo Cifani, Maria Vittoria Micioni Di Bonaventura   +7 more
wiley   +1 more source

Biomimetic MCC950‐loaded cerium‐layered double hydroxide nanoparticles for targeted treatment of Type 1 diabetes in streptozotocin‐induced mice

British Journal of Pharmacology, EarlyView.
The CLMBM nanoparticle (NP) system demonstrates strong and targeted anti‐ROS, antiapoptotic and anti‐inflammatory properties within the pancreas, thereby inhibiting the onset and progression of type 1 diabetes. Background and Purpose The destruction of β‐cells in type 1 diabetes is driven by signalling cascades that ultimately lead to cell apoptosis ...
Huiwen Pang, Zhuo Chen, Youzhi Wu, Thanh‐Truc Nguyen, Jingjing Wang, David M. Klyne, Zhi Ping Xu, Chen Chen, Alan Rowan, Felicity Y. Han   +9 more
wiley   +1 more source

Investigation of Spexin Effects on Insulin‐Dependent Pathway Genes in High‐Glucose‐Induced Insulin‐Resistant C2C12 Myotubes

FASEB BioAdvances, Volume 8, Issue 6, June 2026.
This study investigated spexin in high‐glucose–induced insulin‐resistant C2C12 myotubes, focusing on its ability to modulate insulin‐signaling pathways and the glucose transporter GLUT4. These findings highlight spexin's potential role in improving peripheral insulin sensitivity by regulating key molecular targets involved in glucose homeostasis ...
Ann Sze Cheah, Ji Wei Tan, Faizul Jaafar, Wendy Wai Yeng Yeo   +3 more
wiley   +1 more source

Capillary area in early low-dose streptozocin-treated mice

, 1990
It has been reported that vasoconstriction of intra-islet capillaries plays an important role in the initiation of the insulitis seen in the islets of Langerhans of diabetic animals.
MEZZOGIORNO V, ESPOSITO V., CHIEFFI BACCARI G, PAPACCIO, Gianpaolo   +3 more
core   +1 more source

Betulin Protects Against Cardiac Hypertrophy by Improving AMPK/Nrf2‐Dependent Mitochondrial Function

Phytotherapy Research, Volume 40, Issue 5, Page 2878-2894, May 2026.
Betulin effectively mitigates pressure overload‐induced cardiac hypertrophy in both Ang II‐infused and TAC‐operated mice. Mechanistically, betulin activated AMPK phosphorylation, promoted Nrf2 nuclear translocation, and upregulated antioxidant genes (HO‐1 and NQO‐1), thereby restoring mitochondrial function in cardiomyocytes.
Bei Zheng, Mingyang He, Haiying Wu, Tianjie Zhang, Yuxia Jiang, Chuanwei Xin, Meiling Zhang, Jiaqi He, Lulu Zheng   +8 more
wiley   +1 more source

Dynamics of heart rate variability in rats with streptozotocin-induced diabetes

Сахарный диабет, 2019
Background: Diabetes mellitus (DM) has a negative impact on all organs. This is due to insufficiency of blood supply and the disruption of the trophic function of the nervous system.
Maria P. Morozova, Svetlana A. Gavrilova, Evgeniy V. Ivanov, Anna M. Gorbacheva, Ekaterina M. Rzhavina, Aleksey K. Erdyakov, Zera N. Dzhemilova, Ekaterina V. Artemova, Alla Y. Tokmakova, Vladimir B. Koshelev, Gagik R. Galstyan   +10 more
doaj   +1 more source