Results 51 to 60 of about 8,779 (217)

Design of Single‐Atom Nanozymes for Precision Treatment of Erectile Dysfunction with Integrated Single‐Cell RNA Sequencing and Machine Learning

Advanced Science, Volume 13, Issue 36, 29 June 2026.
It is innovatively utilized single‐cell RNA sequencing to explore the underlying causes of diabetes mellitus‐induced erectile dysfunction, followed by machine learning‐driven design of a single‐atom nanozyme (Fe‐DMOF) for precision treatment of erectile dysfunction.
Xiang Zhou, Xi Zhang, Sihan Chen, Mengchi Yu, Yilan Hu, Chi Gan, Xianghu Meng, Long Li, Ninghong Song   +8 more
wiley   +1 more source

Growth of intraportally transplanted islets under liver regeneration stimulus and restoration of normoglycemia in streptozocin-diabetic rats [PDF]

, 1998
Background. Limitation of β-cell growth after intraportal islet transplantation plays an important role in graft failure. To induce transplanted β-cell proliferation, we studied the effect of compensatory liver growth in diabetic rats that had a ...
ROZGA J, RICCI, Daniele, FOGLI L, DEMETRIOU AA, AZZENA, Gianfranco, MORSIANI E   +5 more
core   +1 more source

Molecular mechanism of ischemic postconditioning in promoting diabetic ischemic brain injury repair via the microRNA‐34a–BDNF–SIX3 signaling axis

Animal Models and Experimental Medicine, Volume 9, Issue 6, Page 1126-1141, June 2026.
Diabetes combined with ischemic stroke (DMIS) exacerbates brain infarct size and neuronal damage compared to nondiabetic ischemic stroke (IS). This study reveals that microRNA‐34a (miR‐34a) plays a key role in DMIS pathogenesis: miR‐34a directly targets and suppresses brain‐derived neurotrophic factor (BDNF) and Sine oculis homeobox 3 (SIX3), promoting
Ling Zhao, Chunlan Zou, Junxian Li, Yang Yang, Yuanyuan Han, Tingyu Ke   +5 more
wiley   +1 more source

Cinnamaldehyde attenuates streptozocin-induced diabetic osteoporosis in a rat model by modulating netrin-1/DCC-UNC5B signal transduction

Frontiers in Pharmacology
Background: Cinnamaldehyde (CMD) is a major functional component of Cinnamomum verum and has shown treatment effects against diverse bone diseases. This study aimed to assess the anti-diabetic osteoporosis (DOP) potential of diabetes mellitus (DM) and to
Songjie Ji, Songjie Ji, Bingjia Zhao, Yuan Gao, Jun Xie, Huijun Han, Qunli Wu, Dan Yang   +7 more
doaj   +1 more source

Investigation of Spexin Effects on Insulin‐Dependent Pathway Genes in High‐Glucose‐Induced Insulin‐Resistant C2C12 Myotubes

FASEB BioAdvances, Volume 8, Issue 6, June 2026.
This study investigated spexin in high‐glucose–induced insulin‐resistant C2C12 myotubes, focusing on its ability to modulate insulin‐signaling pathways and the glucose transporter GLUT4. These findings highlight spexin's potential role in improving peripheral insulin sensitivity by regulating key molecular targets involved in glucose homeostasis ...
Ann Sze Cheah, Ji Wei Tan, Faizul Jaafar, Wendy Wai Yeng Yeo   +3 more
wiley   +1 more source

Effect of Telmisartan on Hippocampal Alterations Induced by Streptozocin in Male Rats [PDF]

, 2015
Introduction: Basic experiments suggest that telmisartan, is unique among angiotensin receptor blockers in which it has a role in neural injury, neuroinflammation, and cognitive function by activating peroxisome proliferator activating receptor gamma ...
Alabbassi, Mustafa G.
core   +1 more source

Betulin Protects Against Cardiac Hypertrophy by Improving AMPK/Nrf2‐Dependent Mitochondrial Function

Phytotherapy Research, Volume 40, Issue 5, Page 2878-2894, May 2026.
Betulin effectively mitigates pressure overload‐induced cardiac hypertrophy in both Ang II‐infused and TAC‐operated mice. Mechanistically, betulin activated AMPK phosphorylation, promoted Nrf2 nuclear translocation, and upregulated antioxidant genes (HO‐1 and NQO‐1), thereby restoring mitochondrial function in cardiomyocytes.
Bei Zheng, Mingyang He, Haiying Wu, Tianjie Zhang, Yuxia Jiang, Chuanwei Xin, Meiling Zhang, Jiaqi He, Lulu Zheng   +8 more
wiley   +1 more source

Effect of Ramipril Alone Compared to Ramipril with Eplerenone on Diabetic Nephropathy in Streptozocin-Induced Diabetic Rats [PDF]

, 2010
<i>Background/Aims:</i> We studied the effect of the combined treatment with an angiotensin-converting enzyme (ACE) inhibitor (ramipril) and eplerenone compared with ramipril alone in streptozocin-induced diabetic rats.
Konstantinos Kallaras, Georgios Karkavelas, Angeliki Cheva, Thomas A. Mavrakanas, Maria Mironidou-Tzouveleki   +4 more
core   +1 more source

The effects of crocin on the serum levels of sex hormone and NO in streptozotocin – induced diabetic rats.

مجله علمی دانشگاه علوم پزشکی کردستان, 2018
Background and Aim: Diabetes can lead to reduced fertility in men by production of free radicals. Crocin (the effective component of saffron) with its antioxidant property can be effective in elimination of free radicals.
Hananeh Bahojb Soldozi, Faramarz Jalili, Maryam Sohrabi, Zahra Keshtmand, Cyrus Jalili   +4 more
doaj  

Kisspeptin as a test of hypothalamic dysfunction in pubertal and reproductive disorders

Andrology, Volume 14, Issue 4, Page 1002-1016, May 2026.
Abstract The hypothalamic–pituitary–gonadal axis is regulated by the gonadotropin‐releasing hormone pulse generator in the hypothalamus. This is comprised of neurons that secrete kisspeptin in a pulsatile manner to stimulate the release of GnRH, and, in turn, downstream gonadotropins from the pituitary gland, and subsequently sex steroids and ...
Aureliane C. S. Pierret, Aaran H. Patel, Elisabeth Daniels, Alexander N. Comninos, Waljit S. Dhillo, Ali Abbara   +5 more
wiley   +1 more source